Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study

Praveen-kumar, S.; Sinha, Sanjib; Taly, AB; Jayasree, S; Ravi, Vasanthapuram; Vijayan, Joy; Ravishankar, S.

doi:10.1016/j.clinph.2007.06.008

Cited by 60 publications

(46 citation statements)

References 22 publications

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“…In SSPE (suggested by the presence of PLIDDs in a child with dementia and myoclonic jerks), the stereotyped complexes, occurring at a regular interval and having a constant relationship to myoclonus, make this as one of the most characteristic and disease-specific of all EEG patterns 34,[48][49][50][51] . The early descriptions, by Cobb 48 , in 1966, characterized the stage II of SSPE by bilaterally symmetrical and synchronous generalized, stereotyped high amplitude delta waves, called Radermacker or "R" complexes, recurring at regular intervals of 5 to 15 seconds, although less specific and atypical EEG changes have been described 49 . With advancing disease, the interval between the discharges becomes progressively smaller 2,49 .…”

Section: Generalized Periodic Epileptiform Dischargesgpedsmentioning

confidence: 99%

“…The clinical and EEG correlation, response to AEDs and monitoring with serial EEG recordings may be helpful considerations in the differential diagnosis 35,[45][46][47] . PLIDDs usually have a frequency of at least 4.0 seconds between the discharges 48,49 . They are more specific with respect to the etiology and may be encountered in disorders like some toxic encephalopathies ( for baclofen or ketamine, for example), anoxic brain injury and SSPE 3 .…”

Section: Generalized Periodic Epileptiform Dischargesgpedsmentioning

confidence: 99%

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Periodic EEG patterns: importance of their recognition and clinical significance

Andraus

Alves-Leon

2012

Arq. Neuro-Psiquiatr.

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Periodic electroencephalographic (EEG) patterns consist of discharges usually epileptiform in appearance, which occur at regular intervals, in critical patients. They are commonly classified as periodic lateralized epileptiform discharges (PLEDs), bilateral independent PLEDs or BIPLEDs, generalized epileptiform discharges (GPEDs) and triphasic waves. Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) are peculiar EEG patterns, which may be present as periodic discharges. The aim of this study is to make a review of the periodic EEG patterns, emphasizing the importance of their recognition and clinical significance. The clinical significance of the periodic EEG patterns is uncertain, it is related to a variety of etiologies, and many authors suggest that these patterns are unequivocally epileptogenic in some cases. Their recognition and classification are important to establish an accurate correlation between clinical, neurological, laboratorial and neuroimaging data with the EEG results.

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Section: Generalized Periodic Epileptiform Dischargesgpedsmentioning

confidence: 99%

Section: Generalized Periodic Epileptiform Dischargesgpedsmentioning

confidence: 99%

Periodic EEG patterns: importance of their recognition and clinical significance

Andraus

Alves-Leon

2012

Arq. Neuro-Psiquiatr.

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“…It should also be noted that atypical EEG findings can be observed in SSPE, and it has been reported that typical patterns can be seen in EEG recordings made when such patients are given diazepam. This finding suggests that EEG recordings may be more sensitive for SSPE diagnosis when patients are taking diazepam (11).…”

Section: Discussionmentioning

confidence: 83%

Process From Diagnosis To Treatment Of 3 SSPE Cases Presented At The Late Age

Bican¹,

Bora²

2015

tnd

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Subacute sclerosing panencephalitis (SSPE) is diagnosed with clinical evaluation including history and physical evaluation along with electroencephalogram (EEG), magnetic resonance imaging of the brain and cerebrospinal fluid (CSF) analysis. A total of 3 patients with SSPE (mean age=25.3 years) who were admitted to the Department of Neurology at Uludağ University Faculty of Medicine, were evaluated retrospectively. Clinical staging was performed using Risk and Haddad's classification. Time to SSPE diagnosis from initial symptoms ranged from 10 days to 3 months; the patients presented to a physician two months after their symptoms were recognized; weakening of mental capacities attracted the attention of members of their families. EEG examinations revealed slow baseline activity and penetrating slow discharges with regular high amplitudes every 8-10 seconds. Although immunoglobulin (Ig) M for measles was negative, IgG was positive in the cerebrospinal fluid and serum samples of all patients. All patients received isoprinosine, and various doses of valproic acid and clonazepam during their treatment. One patient died 13 months after the diagnosis, the other two continue to be followed up. SSPE infection should be considered in central nervous system-involved rapidly-progressing late-onset adult diseases because there has recently been a rapid increase in the number of reported cases of SSPE.Keywords: Subacute sclerosing panencephalitis, prognosis, late presentation Subakut slerozan panensefalit (SSPE) elektroensefalografi (EEG), kranyal manyetik rezonans (MR) görüntüleme ve klinik belirtileri değerlendirip, hikayeleri, fizik muayenedeki değişikliği ve EEG ve beyin omurilik sıvısı (BOS) incelemeleri ile tanı konur. Uludağ Üniversitesi Tıp Fakültesi, Nöroloji Kliniği'nde toplam 3 SSPE'li (yaş ortalaması=25,3) hasta retrospektif olarak değerlendirildi. SSPE tanısı semptomların başlangıcından 10 gün ile 3 ay arasında konuldu. EEG incelemelerinde 8-10 saniye süreli yüksek amplitüdlü yavaş dalgalar ve temel aktivitede yavaşlama gözlendi. BOS örneklerinde kızamık IgM negatif iken IgG pozitif, serumda hepsi pozitif idi. Valproik asit ve klonazepam değişik dozlarda ve sürede kullanıldı tüm olgulara Isoprinosine verildi. Bir olgu 13 ay sonra kaybedildi, diğer olgular takip edilmektedir. SSPE enfeksiyonu santral sinir sistemini tutup hızlıca progrese olmaktadır ve son zamanlarda geç yaşta görülen SSPE olgularının sunumları hızla artmaktadır.

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“…Periodic complexes may not completely meet the characteristics of typical periodic complexes, which are designated as atypical periodic complexes. In addition to typical or atypical periodic paroxysms, several other EEG abnormalities may be seen [4]. Both atypical periodic complexes and the other EEG abnormalities, which are not uncommon, may result in misleading interpretations of EEG findings.…”

Section: Introductionmentioning

confidence: 99%

Role of Routine Benzodiazepin in Eliciting Classical Electroencephalogram (EEG) Response in Suspected Sub-Acute Sclerosing Panencephalitis (SSPE) Cases

Chowdhury¹,

Saha²,

Yusuf³

et al. 2017

WJNS

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Background: EEG could be normal or atypical in spite of suggestive clinical features and positive measles Ab of SSPE cases which could have typical EEG pattern after Benzodiazepine. Objectives: The purpose of the present study was to find out the necessity of administration of benzodiazepine during EEG recording of SSPE cases as well as to compare the efficacy of diazepam and midazolam in eliciting EEG pattern. Methodology: This double blind, parallel, single centered, non-randomized clinical trial was conducted in the Department of Pediatric Neurology at National Institute of Neurosciences, Dhaka, Bangladesh from July 2014 to June 2015 for a period of 1 (one) year. All the clinical and investigational suspected cases of sub-acute Sclerosing Panencephalitis (SSPE) children in both sexes were included as study population. Others neurodegenerative diseases including Wilson's disease were excluded from this study. Patients were divided into two groups named as group A who were given diazepam and the other group B was given midazolam in IV during EEG recording. The clinical outcomes were measured and were recorded in a pre-designed data sheet. Result: The characteristic typical periodic slow wave complex (PSWC) was found only in 8 (30.8%) patients among the 26 (100.0%) before intervention with benzodiazepines. The remaining 18 (69.2%) had non-typical PSWC of which 10 (38.5%) were normal, 3 (11.5%) with atypical PSWC and 5 (19.2%) were with other EEG findings. After intervention with benzodiazepines, 23 (88.5%) had shown typical PSWC and only 3 (11.5%) had non-typical PSWC. Among the typical PSWC cases after interHow to cite this paper: Chowdhury, Y

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Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study

Cited by 60 publications

References 22 publications

Periodic EEG patterns: importance of their recognition and clinical significance

Periodic EEG patterns: importance of their recognition and clinical significance

Process From Diagnosis To Treatment Of 3 SSPE Cases Presented At The Late Age

Role of Routine Benzodiazepin in Eliciting Classical Electroencephalogram (EEG) Response in Suspected Sub-Acute Sclerosing Panencephalitis (SSPE) Cases

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