Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment

Brazète, Jessica Rodrigues; Montplaisir, Jacques; Petit, Dominique; Postuma, Ronald B.; Bertrand, Jean‐Marie; Marchand, Daphné Génier; Gagnon, Jean‐François

doi:10.1016/j.sleep.2013.06.013

Cited by 67 publications

(56 citation statements)

References 29 publications

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“…Whether the contradicting findings are due to methodological reasons only, have to be investigated in future studies, e.g., by applying different automatic spindle detectors on the same dataset and on data from different derivations, and see if the morphological alterations are consistent across detectors, manually scorings and derivations. EEG slowing has been frequently reported in PD (Petit et al, 2004;Rodrigues Brazète et al, 2013), including slowing in occipital, temporo-occipital and frontal regions (Sirakov and Mezan, 1963;Soikkeli et al, 1991;Primavera and Novello, 1992). It is therefore not surprising that we found slower SS oscillation frequencies in PD patients.…”

Section: Discussionsupporting

confidence: 57%

Sleep spindle alterations in patients with Parkinson's disease

et al. 2015

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Section: Discussionsupporting

confidence: 57%

Sleep spindle alterations in patients with Parkinson's disease

et al. 2015

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“…Specifically, patients with iRBD and PD have been reported to have EEG frequency slowing (Rodrigues Brazète et al, 2013), changed EEG during REM sleep (Christensen et al, 2014a;Fantini et al, 2003;Hansen et al, 2013), changed morphology or fewer rapid or slow eye movements (Christensen et al, 2014a and sleep spindles (SS) (Christensen et al, 2014b;Latreille et al, 2014), and display RSWA. The listed findings contribute to very altered sleep and consequently, sleep stage scoring this pathology is associated with high inter-rater variability (Danker-Hopfe et al, 2004;Jensen et al, 2010).…”

Section: Automatic Staging Of Sleepmentioning

confidence: 99%

Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease

et al. 2015

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“…The Montreal team investigated the relation between the result of waking EEG spectral analysis and the cognitive variables in 42 untreated iRBD patients [46]. That study found that RBD + MCI patients had a higher slow-to-fast EEG frequency ratio than RBD - MCI patients and controls in the parietal, temporal and occipital regions.…”

Section: Relationship Between Eeg Slowing and Cognitive Impairment Inmentioning

confidence: 99%

Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder

2015

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The REM sleep behavior disorder (RBD) is a type of parasomnia manifested by vivid, often frightening dreams associated with motor behaviors during REM sleep, sometimes causing injuries to patients themselves or to their bed partners. The polysomnographic features of RBD include increased muscle activity during REM sleep (REM sleep without atonia). The majority of RBD-affected persons are older men. The disorder might be idiopathic (iRBD) or secondary to neurological disorders of various kinds. iRBD management with pharmaceutical measures is usually straightforward and effective. Several longitudinal studies have revealed that a high proportion of iRBD patients convert to α-synucleinopathies such as Parkinson's disease and dementia with Lewy body disease (DLB). Considering this, many studies have been conducted to identify common clinical markers between α-synucleinopathies and iRBD or indicators for the future development of α-synucleinopathies in iRBD patients. In this context, electroencephalographic (EEG) slowing occurring while awake and asleep, which is frequently observed in DLB, has received much attention. Clarification of the association between EEG slowing and the presence of mild cognitive impairment, which is also commonly seen in early stages of DLB, has been particularly expected to offer a breakthrough for the identification of cases which might convert to α-synucleinopathies. In this article, we introduce the progress in quantitative EEG research in iRBD during the past decade. We also discuss the relationship between EEG findings and cognitive decline as well as the mechanisms of EEG changes or cognitive abnormalities in patients with the disorder.

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Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment

Cited by 67 publications

References 29 publications

Sleep spindle alterations in patients with Parkinson's disease

Sleep spindle alterations in patients with Parkinson's disease

Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease

Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder

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