Electroencephalogram patterns during sleep reflux in infants

Sondheimer, Judith M.; Hoddes, Eric

doi:10.1016/0016-5085(91)90727-3

Cited by 11 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, both studies were performed in older infants (3–35 months old) in a context of respiratory disorders. Sondheimer and Hoddes (1991) did not observe sleep pattern differences when comparing infants with and without pathological levels of GOR. In contrast, Harris et al.…”

Section: Introductioncontrasting

confidence: 55%

“…(2003) did not find any sleep disruption in 3‐month‐old infants with a RI < 5%, whereas the presence of severe GOR (pH < 4 for more than 10% of total time) was associated with a greater amount of AS. Moreover, in older infants (3–35 months old), Sondheimer and Hoddes (1991) did not find differences between the sleep patterns of infants with and without pathological GOR. Nevertheless, the frequency of GOR episodes was found to influence the continuity of sleep: the higher the GOR frequency, the higher the sleep stage change frequency.…”

Section: Discussionmentioning

confidence: 57%

“…Although sleep integrity is of paramount importance in neurobehavioural development, body growth and physiological regulation in neonates (Curzi‐Dascalova and Challamel, 2000; Mirmiran and Ariagno, 2003), we are only aware of two studies (Harris et al. , 2003; Sondheimer and Hoddes, 1991) that have investigated the impact of GOR (as assessed by pH‐metry) on sleep. However, both studies were performed in older infants (3–35 months old) in a context of respiratory disorders.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between sleep and acid gastro‐oesophageal reflux in neonates

Ammari

Djeddi

Léké

et al. 2011

Journal of Sleep Research

View full text Add to dashboard Cite

SUMMARYThe aim of the present study was to investigate the impact of gastrooesophageal acid reflux on sleep in neonates and, reciprocally, the influence of wakefulness (W) and sleep stages on the characteristics of the reflux (including the retrograde bolus migration of oesophageal acid contents). The pH and multichannel intraluminal impedance were measured during nocturnal polysomnography in 25 infants hospitalised for suspicion of gastro-oesophageal reflux. Two groups were constituted according to whether or not the infants displayed gastro-oesophageal reflux (i.e. a reflux group and a control group). There were no differences between the reflux and control groups in terms of sleep duration, sleep structure and sleep state change frequency. Vigilance states significantly influenced the gastro-oesophageal reflux pattern: the occurrence of gastro-oesophageal reflux episodes was greater during W (59 ± 32%) and active sleep (AS; 35 ± 30%) than during quiet sleep (QS; 6 ± 11%), whereas the mean duration of gastro-oesophageal reflux episodes was higher in QS than in W and AS. The percentage of retrograde bolus migrations of distal oesophageal acid content was significantly higher in AS (62 ± 26%) than in W (42 ± 26%) and QS (4.5 ± 9%). In neonates, gastro-oesophageal reflux occurred more frequently during W, whereas the physiological changes associated with sleep state increase the physiopathological impact of the gastro-oesophageal reflux. The duration of oesophagus-acid contact was greater during sleep; AS facilitated the retrograde migration of oesophageal acid content, and QS was characterised by the risk of prolonged acid mucosal contact.

show abstract

Section: Introductioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between sleep and acid gastro‐oesophageal reflux in neonates

Ammari

Djeddi

Léké

et al. 2011

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…Sondheimer and Hoddes have addressed this issue in infants with apnoea or chronic lung disease and were unable to show any differences in the pattern on electroencephalography during sleep between those infants with and without reflux. 12 What can we conclude? Gastro-oesophageal reflux is certainly common in infants with ALTE and should be sought in them all, using extended oesophageal pH monitoring.…”

mentioning

confidence: 96%

Silent gastro-oesophageal reflux: how much do we miss?

Booth¹

1992

Archives of Disease in Childhood

View full text Add to dashboard Cite

“…The reduction in Stage 0 sleep in the overall record is typical of older infants. The overall partition of sleep stages in the far right column is within normal limits for age(12). b P < 0.01 ; drift vs. rapid onset.…”

mentioning

confidence: 85%

Gastroesophageal Reflux with Drifting Onset in Infants

Sondheimer,

Hoddes

1992

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

SummaryWe have characterized the gastroesophageal reflux (GER) episodes which occurred during sleep in 28 infants with pathologic gastroesophageal reflux and 10 symptomatic age‐matched controls without gastroesophageal reflux. We describe three kinds of episodes during the sleeping period‐awake episodes which occur completely during electroencephalogram (EEG)‐defined wakefulness associated with clinical evidence of the waking state (62 episodes), episodes occurring during EEG‐defined sleep which have a rapid drop in pH at their onset (119 episodes), and episodes occurring during EEG‐defined sleep in which the esophageal pH drifts down slowly over a period up to 30 min (113 episodes). Only 9 of the 10 control subjects experienced any reflux episodes during monitoring. The total number of episodes of reflux in controls (34) was less than the total number in reflux subjects (260). Controls did, however, experience all three types of reflux episode. Awake episodes all had a rapid drop in pH at their onset and were characterized by a short acid clearance time (2.0 ± 0.3 min in reflux patients and 1.0 ± 0.2 min in controls). The sleep episodes with rapid onset had longer mean acid clearance time than the awake episodes, significantly so in GER subjects (20.1 ± 6.8 min in reflux subjects and 2.6 +1.3 min in controls). Body movement was noted at the onset of 93.4% of rapid‐onset sleep episodes in reflux subjects and 88.9% in controls. Body movement was also common at the termination of rapid‐onset sleep episodes (77.8% of rapid‐onset episodes in reflux subjects and 80.0% in controls). The drift‐onset sleep episodes in GER subjects were characterized by a low frequency of body movements at their onset (body movement seen in 34.9% of drift‐onset episodes), a higher minimum pH (3.6 ±0.1 versus 2.8 ± 0.2 drift‐onset vs. rapid‐onset episodes), a tendency to start in the deeper EEG sleep stages when compared to rapid‐onset sleep episodes, and a decreased frequency of movement arousal. Mean acid clearance time of drift‐onset sleep episodes was similar to rapid‐onset sleep episodes in GER subjects (15.3 ± 6.1 min). Similar characteristics were noted in the few episodes of drift‐onset reflux observed in the control subjects except that drift episodes had significantly greater mean acid clearance time than rapid‐onset episodes (19.4 ± 9.9 min). We conclude that sleep reflux episodes with drifting onset are a significant part of total reflux occurring during the sleeping period. The similarities between rapid‐ and drift‐onset sleep episodes with respect to acid clearance time, and presence of movement at the termination suggests that the mechanisms of clearance of these two episodes may be similar. The differences in onset characteristics between these two episode types, however, suggests the possibility that they may be initiated by different mechanisms

show abstract

Electroencephalogram patterns during sleep reflux in infants

Cited by 11 publications

References 8 publications

Relationship between sleep and acid gastro‐oesophageal reflux in neonates

Relationship between sleep and acid gastro‐oesophageal reflux in neonates

Silent gastro-oesophageal reflux: how much do we miss?

Gastroesophageal Reflux with Drifting Onset in Infants

Contact Info

Product

Resources

About