Electrodynamic smooth muscle sphincter

An artificial sphincter prototype has been developed, specifically designed for comfortable remote control by fecally incontinent patients. The artificial sphincter includes a fluid reservoir, an occlusive cuff, and a micropump based on piezo-technology in a single unit. Continence and implantation management were evaluated around isolated porcine anal canals and in vivo. The design of the prosthesis reduces the occlusion pressure and allows low inflation volumes (6.5-16 mL). Operating pressures between 24 and 58 mm Hg indicate a minor risk of ischemic injury to the bowel. The operation time is estimated at about 7 days with no recharging of the battery. The novel prototype is a highly integrated prosthesis for placement around the anal canal or lower rectum, effecting continence with comfortable control.

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In Vitro and In Vivo Assessment of an Intelligent Artificial Anal Sphincter in Rabbits

Huang

Shi

Chen

et al. 2011

Artificial Organs

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Artificial sphincters have been developed for patients with fecal incontinence, but finding a way to make such sphincters more "intelligent" remains a problem. We assessed the function of a novel intelligent artificial anal sphincter (IAAS) in vitro and in vivo in rabbits. After the prosthesis was activated, rabbits were continent of feces during 81.4% of the activation time. The fecal detection unit provided 100% correct signals on stool in vitro and 65.7% in vivo. The results indicated that the IAAS could efficiently maintain continence and detect stool; however, the IAAS is still in the preliminary experimental stage and more work is needed to improve the system.

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Electrodynamic smooth muscle sphincter

Abstract: The NANC-induced relaxation mechanism of porcine fundus preparations could be transferred to an efficient smooth muscle sphincter with a high threshold of continence and electrically controlled defecation.

Cited by 4 publications

References 19 publications

Autologous Neosphincters and Novel Technologies for Fecal continence

Autologous Neosphincters and Novel Technologies for Fecal continence

Development of a Novel, Remote‐Controlled Artificial Bowel Sphincter Through Microsystems Technology

In Vitro and In Vivo Assessment of an Intelligent Artificial Anal Sphincter in Rabbits

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