Electrode Placement and Fluid Flow Rates in Microfluidic Electrochemical Devices

Dydek, E. Victoria; Petersen, Montana V.; Nocera, Daniel G.; Jensen, Klavs F.

doi:10.1149/2.007211jes

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…Integrated pseudo reference electrodes [23] based on gold [24,25] or Ag/AgCl [26][27][28][29][30] have been used in lab-onchip devices, but reporting potential measurements against these electrodes is problematic, as they are not based on thermodynamic equilibrium [31], or they are not separated from the sample electrolyte. Some successful implementations of stable integrated Ag/AgCl reference electrodes have been made, using laminar flow [32] or a nanochannel [33] in order to separate the sample electrolyte from the reference electrolyte while maintaining electrical contact. When working with platinum or gold electrodes however, it is advisable to avoid the presence of chloride ions due to adsorption and anodic corrosion of the electrode [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

A microfluidic electrochemical cell with integrated PdH reference electrode for high current experiments

Fanavoll

Harrington

Sunde

et al. 2017

Electrochimica Acta

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A microfluidic electrochemical cell with integrated PdH reference electrode for high current experiments. Electrochimica Acta, 225, 69-77. AbstractAn on-chip thin-film palladium hydride reference electrode is described for use with microfluidic electrochemical cells. A Pd electrode fabricated by photolithographic methods is charged with hydrogen in-situ with a simple current step technique. The placement of the reference electrode in a side channel means that it is unaffected by species in the main channel. Placement upstream of the working and sense electrodes is shown to be a significant improvement over cells with the reference electrode placed externally. The adverse effects of solution resistance are investigated quantitatively, and it is shown that the described configuration allows for high current experiments while maintaining accurate potential measurement. A simple formula for calculating the maximum current density for a certain cell geometry and electrolyte resistivity is presented.

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Section: Introductionmentioning

confidence: 99%

A microfluidic electrochemical cell with integrated PdH reference electrode for high current experiments

Fanavoll

Harrington

Sunde

et al. 2017

Electrochimica Acta

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“…In conjunction with a working electrode, the counter electrode is used to apply current to the working electrode through an electrolytic solution. The performance and sensitivity of electrodes in OOC can be affected by variety of parameters including electrode position, electrode size, biofouling, and flow rate . Therefore, the care needs to be taken in the placement of electrodes and materials.…”

Section: Sensory Systems In Organ‐on‐a‐chip Platformsmentioning

confidence: 99%

Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

Ahadian

Civitarese

Bannerman

et al. 2017

Adv Healthcare Materials

239

162

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Significant advances in biomaterials, stem cell biology, and microscale technologies have enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs, referred to as organ-on-a-chip (OOC) platforms, have emerged as a powerful tool in tissue analysis and disease modeling for biological and pharmacological applications. A variety of biomaterials are used in tissue fabrication providing multiple biological, structural, and mechanical cues in the regulation of cell behavior and tissue morphogenesis. Cells derived from humans enable the fabrication of personalized OOC platforms. Microscale technologies are specifically helpful in providing physiological microenvironments for tissues and organs. In this review, biomaterials, cells, and microscale technologies are described as essential components to construct OOC platforms. The latest developments in OOC platforms (e.g., liver, skeletal muscle, cardiac, cancer, lung, skin, bone, and brain) are then discussed as functional tools in simulating human physiology and metabolism. Future perspectives and major challenges in the development of OOC platforms toward accelerating clinical studies of drug discovery are finally highlighted.

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“…The performance of electrodes within a microchannel depends on a variety of parameters including electrode position and flow rate. 109 Examples of separations coupled with electrochemical detection include the isolation of hydrolysis products, 110 the monitoring of biomolecule release from individual cells, 111 and the quantitation of bioactive molecules in serum. 112 The main challenge in integrating electrochemical detection with electrophoretic separations has been isolating the separation and detection modules.…”

Section: A Electrochemistry and Microfluidicsmentioning

confidence: 99%

“…The performance of electrodes within a microchannel depends on a variety of parameters including electrode position and flow rate. 109…”

Section: A Convergence Of Fieldsmentioning

confidence: 99%

Electrochemistry, biosensors and microfluidics: a convergence of fields

2015

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Electrochemistry, biosensors and microfluidics are popular research topics that have attracted widespread attention from chemists, biologists, physicists, and engineers. Here, we introduce the basic concepts and recent histories of electrochemistry, biosensors, and microfluidics, and describe how they are combining to form new application-areas, including so-called "point-of-care" systems in which measurements traditionally performed in a laboratory are moved into the field. We propose that this review can serve both as a useful starting-point for researchers who are new to these topics, as well as being a compendium of the current state-of-the art for experts in these evolving areas.

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Electrode Placement and Fluid Flow Rates in Microfluidic Electrochemical Devices

Cited by 8 publications

References 23 publications

A microfluidic electrochemical cell with integrated PdH reference electrode for high current experiments

A microfluidic electrochemical cell with integrated PdH reference electrode for high current experiments

Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

Electrochemistry, biosensors and microfluidics: a convergence of fields

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