Electroconvulsive therapy as a potential therapeutic option in psychiatric‐onset prodromal dementia with Lewy bodies

Kimura, Hiroki; Yokoyama, Haruhiko; Torii, Youta; Fujishiro, Hiroshige

doi:10.1002/gps.5863

Cited by 3 publications

(5 citation statements)

References 12 publications

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“…In the present case, treatment with RUL‐UBP ECT significantly improved Parkinsonism and partially improved depression and meal intake without adverse cognitive effects. Previous reports of ECT for DLB showed improvement in psychiatric symptoms, but improvement in Parkinsonism was inconsistent 2–6 . Additionally, unlike in the present case, significantly improved meal intake was reported in a previous report 4 .…”

Section: Rul‐ubp Ect Bilateral Ect Before Ect After Ect Before Ect Af...contrasting

confidence: 78%

“…Previous reports of ECT for DLB showed improvement in psychiatric symptoms, but improvement in Parkinsonism was inconsistent. [2][3][4][5][6] Additionally, unlike in the present case, significantly improved meal intake was reported in a previous report. 4 Considering the results of previous reports regarding ECT for DLB, [2][3][4][5][6] the effectiveness of ECT for non-psychiatric symptoms in DLB may depend on patient characteristics.…”

supporting

confidence: 64%

“…Additionally, unlike in the present case, significantly improved meal intake was reported in a previous report 4 . Considering the results of previous reports regarding ECT for DLB, 2–6 the effectiveness of ECT for non‐psychiatric symptoms in DLB may depend on patient characteristics.…”

Section: Rul‐ubp Ect Bilateral Ect Before Ect After Ect Before Ect Af...supporting

confidence: 47%

“…1 Several studies have revealed the efficacy of modified electroconvulsive therapy (ECT) for drugresistant psychiatric symptoms such as depression, psychosis, and agitation in these patients. [2][3][4][5][6] However, although ECT may cause cognitive impairment, such as amnesia, and executive function, there are few longitudinal observations of cognitive function before and after ECT. 4,5 Right unilateral ultra-brief pulse (RUL-UBP) ECT has fewer cognitive-related concerns.…”

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confidence: 99%

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Effects of right unilateral ultra‐brief pulse electroconvulsive therapy in a depressed patient with dementia with Lewy bodies: a longitudinal case report

Yamaguchi,

Kobayashi,

Muraosa

et al. 2024

Psychogeriatrics

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Section: Rul‐ubp Ect Bilateral Ect Before Ect After Ect Before Ect Af...contrasting

confidence: 78%

supporting

confidence: 64%

Section: Rul‐ubp Ect Bilateral Ect Before Ect After Ect Before Ect Af...supporting

confidence: 47%

mentioning

confidence: 99%

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Effects of right unilateral ultra‐brief pulse electroconvulsive therapy in a depressed patient with dementia with Lewy bodies: a longitudinal case report

Yamaguchi,

Kobayashi,

Muraosa

et al. 2024

Psychogeriatrics

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“…Many clinical case reports regarding patients with late-onset depression who converted to DLB were rapidly accumulating (Table 1). 17,18,[52][53][54][55][56][57][58][59] The disease duration until development of dementia tended to be longer when initial psychiatric symptoms appeared at younger ages.…”

Section: Late-onset Depressionmentioning

confidence: 99%

Clinical presentations and diagnostic application of proposed biomarkers in psychiatric‐onset prodromal dementia with Lewy bodies

Kobayashi,

Iwata‐Endo,

Fujishiro

2024

Psychogeriatrics

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Research criteria for the diagnosis of prodromal dementia with Lewy bodies (DLB) include three clinical subtypes: mild cognitive impairment with Lewy bodies (MCI‐LB), delirium‐onset prodromal DLB, and psychiatric‐onset prodromal DLB. Late‐onset psychiatric manifestations are at a higher risk of developing dementia, but its relation to prodromal DLB remains unclear. In addition to the risk of severe antipsychotic hypersensitivity reactions, accurate discrimination from non‐DLB cases is important due to the potential differences in management and prognosis. This article aims to review a rapidly evolving psychiatric topic and outline clinical pictures of psychiatric‐onset prodromal DLB, including the proposed biomarker findings of MCI‐LB: polysomnography‐confirmed rapid eye movement sleep behaviour disorder, cardiac [123I]metaiodobenzylguanidine scintigraphy, and striatal dopamine transporter imaging. We first reviewed clinical pictures of patients with autopsy‐confirmed DLB. Regarding clinical reports, we focused on the patients who predominantly presented with psychiatric manifestations and subsequently developed DLB. Thereafter, we reviewed clinical studies regarding the diagnostic applications of the proposed biomarkers to patients with late‐onset psychiatric disorders. Clinical presentations were mainly late‐onset depression and psychosis; however, other clinical manifestations were also reported. Psychotropic medications before a DLB diagnosis may cause extrapyramidal signs, and potentially influences the proposed biomarker findings. These risks complicate clinical manifestation interpretation during the management of psychiatric symptoms. Longitudinal follow‐up studies with standardised evaluations until conversion to DLB are needed to investigate the temporal trajectories of core features and proposed biomarker findings. In patients with late‐onset psychiatric disorders, identification of patients with psychiatric‐onset prodromal DLB provides the opportunity to better understanding the distinct prognostic subgroup that is at great risk of incident dementia. Advances in the establishment of direct biomarkers for the detection of pathological α‐synuclein may encourage reorganising the phenotypic variability of prodromal DLB.

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Duloxetine/sertraline

2023

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Electroconvulsive therapy as a potential therapeutic option in psychiatric‐onset prodromal dementia with Lewy bodies

Cited by 3 publications

References 12 publications

Effects of right unilateral ultra‐brief pulse electroconvulsive therapy in a depressed patient with dementia with Lewy bodies: a longitudinal case report

Effects of right unilateral ultra‐brief pulse electroconvulsive therapy in a depressed patient with dementia with Lewy bodies: a longitudinal case report

Clinical presentations and diagnostic application of proposed biomarkers in psychiatric‐onset prodromal dementia with Lewy bodies

Duloxetine/sertraline

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