Electroconvulsive shock in rats: changes in superoxide dismutase and glutathione peroxidase activity

Eraković, Vesna; Župan, Gordana; Varljen, Jadranka; Radošević, Senka; Simonić, Ante

doi:10.1016/s0169-328x(00)00004-8

Cited by 45 publications

(23 citation statements)

References 30 publications

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“…Similar to our results Erakovic et al (10) reported that single or repeated ECS induced a decrease in SOD and glutation peroxidase (GPX) activities at various brain regions in rats. Baricello et al (11) demonstrated an increase in catalase (CAT) and SOD activities, a decrease in lipid peroxidation, and protein damage in the hippocampus immediately after and up to 30 days after a single or multiple ECS.…”

Section: Discussionsupporting

confidence: 93%

“…While some researchers found an increase (4) in oxidants, others measured a decrease (11); meanwhile, Jornada et al [12] reported no significant changes in oxidative metabolites after ECS. Regarding antioxidants, Erakovic et al (10) and Feier et al [4] measured a decrease, but Baricello et al (11) found an increase.…”

Section: Introductionmentioning

confidence: 98%

“…Protein and lipid changes in cell membrane and activations within the cell result in intracellular free fatty acid accumulation, which in turn causes formation of eicosanoids, lipid peroxides, and free radicals [9]. Antioxidant mechanisms try to minimize the cellular damage by removing hazardous oxidants (10).…”

Section: Introductionmentioning

confidence: 99%

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Depresyonda EKT Sonrası Süperoksit Dismutaz Aktivitesi Düşüyor ve EKT'ye Kötü Yanıtla Korelasyon Gösteriyor

Virit¹,

Dalkılıç²,

Bulut³

et al. 2011

Npa

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ÖZET Amaç:Elektrokonvülzif tedavinin (EKT) oksidatif metabolizma üzerine etkileri ile ilgili literatürün ço¤u hayvan deneylerine dayanmaktad›r ve oksidan/antioksidan dengenin de¤iflti¤ine dair çeliflkili sonuçlar içermektedir. Bu alanda yap›lan ilk insan çal›flmas› olan bu çal›flman›n amac› depresif hastalarda EKT sonras› oksidan ve antioksidanlardaki de¤iflimleri araflt›rmakt›r. Yöntemler: On dört unipolar ve iki bipolar depresyon hastas› çal›flmaya dahil edildi. Kan örnekleri ilk EKT seans›ndan 1 saat once ve 7. EKT seans›ndan 1 saat sonra al›nd›. Plazmada oksidanlardan malondialdehit (MDA), nitrik oksit (NO) ve ksantin oksidaz (XO); antioksidanlardan süperoksit dismutaz (SOD) seviyeleri ölçüldü. Bulgular: Birinci ve 7. EKT seans›ndan sonraki Hamilton Depresyon Ölçe¤i (HAM-D) skorlar› 32.63±9.54 ve 16.50±7.22 idi (t=7.92, df=15, p<0.001). Yedinci EKT sonras› SOD de¤erleri EKT öncesi SOD de¤erlerinden anlaml› olarak düflüktü (p<0.05, Z= -3,459). EKT öncesi ve sonras› MDA, NO ve XO de¤erleri aras›nda anlaml› bir farkl›l›k yoktu (p>0.05). Bununla birlikte, EKT öncesi SOD de¤erleri EKT öncesi HAM-D skorlar› ile anlaml› düzeyde pozitif korelasyon gös-teriyordu (r=0.641, p=0.007). Sonuç: EKT sonras› antioksidan bir enzim olan SOD düzeyindeki düflüfl oksidatif stresi artt›rarak nöronlara zarar verebilir. Bu nedenle EKT uygulama dönemlerinde antioksidan ekleme tedavilerinin olas› faydalar› araflt›r›lmal›d›r. Yine EKT öncesi yüksek oksidan seviyeleri depresyon hastalar›nda EKT'ye kötü yan›t› yordayabilir. (Nöropsikiyatri Arflivi 2010; 47: 247-51) Anahtar kelimeler: Elektrokonvülzif tedavi, Oksidatif metabolizma, Süperoksit dismutaz ABSTRACT Objective: The literature regarding effects of electroconvulsive therapy (ECT) on oxidative metabolism (OM) reports conflicting changes in oxidant and antioxidant status in animal studies. The goal of this first human study was to investigate the changes in oxidants and antioxidants in plasma of depressed patients after ECT. Methods: Fourteen unipolar and two bipolar patients were included in the study. The blood samples were obtained within one hour before the 1 st and within one hour after the 7 th ECT sessions. Oxidants malondialdehyde (MDA), nitric oxide (NO), and xanthine oxidase (XO) and antioxidant superoxide dismutase (SOD) were measured in the plasma. Results: Before the 1 st and after the 7 th ECT sessions, the Hamilton Depression Rating Scale (HDRS) scores were 32.63±9. 54 and 16.50±7.22, respectively (t=7.92, df=15, p<0.001). After the 7 th ECT, SOD values were significantly lower than pre-ECT SOD values (p<0.05, Z= -3,459). There were no significant difference between pre-and post-ECT values of MDA, NO, and XO (p>0.05). However, pre-ECT SOD values were significantly and positively correlated with pre-ECT HDRS scores (r=0.641, p=0.007). Conclusion:The decrease in antioxidant enzyme SOD after ECT may damage the neurons by increasing oxidative stress. Thus, possible benefits of antioxidant supplementation during ECT should be investigated. Additionally, higher pre-ECT o...

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

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Depresyonda EKT Sonrası Süperoksit Dismutaz Aktivitesi Düşüyor ve EKT'ye Kötü Yanıtla Korelasyon Gösteriyor

Virit¹,

Dalkılıç²,

Bulut³

et al. 2011

Npa

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“…Many of the identified genes encode ion channels such as Na + , K + and Ca 2+ channels or other components of neuronal signaling (Meisler et al, 2001;Park et al, 2003). Although the reports are not divergent (Oliver et al, 1990;Mori and Yokoyama, 1993;Murashima et al, 1998;Halliwell and Gutteridge, 1999b;Ben-Menachem et al, 2000;Erakovic et al, 2000;Liang et al, 2000;Patel, 2002), oxidative stress is emerging as a mechanism that may play an important role in the etiology of seizure. However, it is remained unclear which types of antioxidant systems are involved.…”

Section: Introductonmentioning

confidence: 99%

“…The epileptic mutant EL mice had abnormally low levels of SOD isoenzyme activity in the hippocampal area (Murashima et al, 1998). Electroconvulsive shock-induced seizures in rats decreased superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities in various brain regions (Erakovic et al, 2000). Erythrocyte CuZn-SOD was significantly lower in the progressive myoclonic epilepsies patients compared to controls (Ben-Menachem et al, 2000).…”

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confidence: 99%

Proteomic analysis of human cerebral cortex in epileptic patients

Eun

Choi²,

Kwak³

2004

Exp Mol Med

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Abbreviations: 2-DE, 2-dimensional electrophoresis; ESI-Q-TOF, electrospray ionization quadupole time of flight; GPDH, Glycerol phosphate dehydrogenase; GPX, glutathione peroxidase; MALDI-TOF, matrix-assisted laser desorption/ionization-time-of flight; SOD, superoxide dismutase A bstractEpilepsy affects m ore than 0.5% of the w orld population and is know n to be associated w ith a large genetic com ponent eliciting an electrical hyperexcitability in the central nervous system . However, its pathogenic m echanism s rem ain poorly understood. In order to gain greater m olecular incite in the pathogenesis in epilepsy, we analyzed proteom es of hum an cerebral cortices. Q uantitative proteom e analysis w as used to com pare signals corresponding to individual proteins betw een epileptic cerebral cortices from patients w ith temporal lobe epilepsy and age-m atched non-epileptic subjects. To m inim ize individual variations, gender and age of the patients w ere m atched. Changes of several spots w ere consistent am ong 6 pairs of epileptic patients and nonepileptic subjects. O ne of the spots w as identified as the m itochondrial type Mn-superoxide dism utase (M n-SOD) confirm ed by W estern blot analysis w ith M n-SO D antibody and enzym e activity assay. Such results w ere agreeable w ith chem ical and physical param eters given by the 2-dim ensional electrophoresis (2-DE) gel. M n-SO D w as consistently dow n-regulated in epileptic cerebral cortices com pared w ith those of nonepileptic subjects. Our results dem onstrate a clear link betw een pathogenesis of epilepsy and SO D. Additionally, w e identified four proteins that w ere consistently over-expressed in all epileptic tem poral neocortices specim ens and the other four proteins that w ere found to be expressed less than non-epileptic control subjects. These proteom ic data provide cellular m arkers in the understanding mechanism of the epilepsy pathogenesis.

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Catalase andα-tocopherol attenuate blood–brain barrier breakdown in pentylenetetrazole-induced epileptic seizures in acute hyperglycaemic rats

Kaya

Cimen

Kalayci

et al. 2002

Pharmacological Research

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Electroconvulsive shock in rats: changes in superoxide dismutase and glutathione peroxidase activity

Cited by 45 publications

References 30 publications

Depresyonda EKT Sonrası Süperoksit Dismutaz Aktivitesi Düşüyor ve EKT'ye Kötü Yanıtla Korelasyon Gösteriyor

Depresyonda EKT Sonrası Süperoksit Dismutaz Aktivitesi Düşüyor ve EKT'ye Kötü Yanıtla Korelasyon Gösteriyor

Proteomic analysis of human cerebral cortex in epileptic patients

Catalase andα-tocopherol attenuate blood–brain barrier breakdown in pentylenetetrazole-induced epileptic seizures in acute hyperglycaemic rats

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