Electroconvulsive Seizures Stimulate Glial Proliferation and Reduce Expression of Sprouty2 within the Prefrontal Cortex of Rats

Öngür, Döst; Pohlman, Jessica; Dow, Antonia; Eisch, Amelia J.; Edwin, Francis; Heckers, Stephan; Cohen, Bruce M.; Patel, Tarun B.; Carlezon, William A.

doi:10.1016/j.biopsych.2006.11.014

Cited by 54 publications

(41 citation statements)

References 55 publications

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“…For instance, electroconvulsive therapy (ECT) treatment, which can be beneficial to patients with refractory major depressive disorder, leads to increased fractional anisotropy in humans (Nobuhara et al, 2004), suggesting a possible role for myelin plasticity in promoting recovery from mood disorders. In support of this idea, ECT-like treatment in rats leads to increased OPC proliferation (Ongür et al, 2007). Conversely, negative effectors of mood, such as chronic stress, have been shown to negatively impact OPC proliferation and oligodendrocyte density (as discussed above).…”

Section: The Chicken or The Egg? How Behavioral Experiences May Contrmentioning

confidence: 89%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

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Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

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Section: The Chicken or The Egg? How Behavioral Experiences May Contrmentioning

confidence: 89%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

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“…SPRY2 was demonstrated to modulate neuronal differentiation and survival by inhibiting BDNF signaling [63]. Notably, SPRY2 expression in the medial prefrontal cortex, a brain area implicated in mood disorders, was dramatically downregulated in rats receiving repeated electroconvulsive treatments -an effective treatment for major depression [64]. ENDOD1 has been associated with myelin synthesis [65].…”

Section: Chl1 and Paroxetine Sensitivitymentioning

confidence: 98%

Genome-wide Expression Profiling of Human Lymphoblastoid Cell Lines Identifies CHL1 as a Putative SSRI Antidepressant Response Biomarker

et al. 2011

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“…However, whether these changes contribute to the etiology or progression of the disease is not known. Because Spry proteins modulate the proliferation of cells, one study has examined Spry2 expression after electroconvulsive therapy (Ongü r et al, 2007). The findings from these studies show that electroconvulsive therapy decreases Spry2 expression, augments glial cell proliferation and thereby, increases neuronal plasticity (Ongü r et al, 2007).…”

Section: Spry Proteins In Pathological Statesmentioning

confidence: 99%

Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

Edwin

Anderson²,

Ying³

et al. 2009

Mol Pharmacol

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103

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Receptor tyrosine kinase (RTK) signaling is spatially and temporally regulated by a number of positive and negative regulatory mechanisms. These regulatory mechanisms control the amplitude and duration of the signals initiated at the cell surface to have a normal or aberrant biological outcome in development and disease, respectively. In the past decade, the Sprouty (Spry) family of proteins has been identified as modulators of RTK signaling in normal development and disease. This review summarizes recent advances concerning the biological activities modulated by Spry family proteins, their interactions with signaling proteins, and their involvement in cardiovascular diseases and cancer. The diversity of mechanisms in the regulation of Spry expression and activity in cell systems emphasizes the crucial role of Spry proteins in development and growth across the animal kingdom.The Sprouty (Spry) protein was first described by Hacohen et al. (1998) as an inhibitor of fibroblast growth factor (FGF)-stimulated tracheal branching during Drosophila melanogaster development. Subsequent work established D. melanogaster Spry (dSpry) as a widespread inhibitor of receptor-tyrosine kinase (RTK) signaling during organogenesis. For example, spry-null flies or flies harboring loss of function mutations on spry exhibit eye and wing phenotypes indicative of uncontrolled epidermal growth factor receptor (EGFR) signaling (Minowada et al., 1999).Four mammalian spry genes have been defined based on sequence similarity with dSpry. Three homologs of dSpry were first identified in a search of the human expressed

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Electroconvulsive Seizures Stimulate Glial Proliferation and Reduce Expression of Sprouty2 within the Prefrontal Cortex of Rats

Cited by 54 publications

References 55 publications

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Genome-wide Expression Profiling of Human Lymphoblastoid Cell Lines Identifies CHL1 as a Putative SSRI Antidepressant Response Biomarker

Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

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