Electroconductive hydrogels: Synthesis, characterization and biomedical applications

Guiseppi‐Elie, Anthony

doi:10.1016/j.biomaterials.2009.12.052

Cited by 565 publications

(397 citation statements)

References 150 publications

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“…[4,5] However, the electrically nonconductive nature of hydrogels impedes its use for excitable cells such as neural, skeletal and cardiac muscle, and bone cells. [6,7] To extend the utility of hydrogels, conducting 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 3 elements like metallic nanoparticles [8][9][10][11][12][13][14] and inherently conductive polymers (IHPs) [6,[15][16][17][18][19] have been incorporated within hydrogel matrices in order to add conductive properties to the 3D microenvironments.…”

Section: Introductionmentioning

confidence: 99%

Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation

Sawyer

Dong

Venn

et al. 2017

Biomed. Phys. Eng. Express

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New conductive hydrogels with superior biocompatibility continue to be developed in order to serve as bioactive scaffolds capable of modulating cellular functionality for tissue engineering applications. We developed an electrically conductive gelatin methacrylate-poly(aniline) (GelMA-PANi) hydrogel that is permissive of matrix mineralization by encapsulated osteoblast-like cells. Incorporation of PANi clusters within the GelMA matrix increases the electro-conductivity of the composite gel, while maintaining the osteoid-like soft mechanical properties that allows three-dimensional encapsulation of living cells. Viability of human osteogenic cells encapsulated within GelMA-PANi hydrogels was similar to that of GelMA. Cells within GelMA-PANi also demonstrated the capability of depositing mineral within the hydrogel matrix after being chemically induced for two weeks, although the total mineral content was lower as compared to GelMA. Additionally, we demonstrated that the GelMA-PANi-composite hydrogel could be printed in complex, user-defined geometries using digital projection stereolithography.

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Section: Introductionmentioning

confidence: 99%

Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation

Sawyer

Dong

Venn

et al. 2017

Biomed. Phys. Eng. Express

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“…The properties of hydrogels such as the functional groups, chemical composition, hydrophilic-hydrophobic balance, surface morphology, and presence of adherent proteins are essential for the regulation of cellular interactions. Therefore, the performance of a hydrogel material relies highly upon the properties of the boundaries in tissue engineering applications because the interactions between the hydrogel materials and environments occur mainly on its surfaces [1][2][3][4]. The hydroxyethyl methacrylate (pHEMA) hydrogel possesses good biocompatibility as evidenced by its large scale use in biomedical and biotechnological applications such as contact lenses, drug delivery systems, and soft tissue prosthesis [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Poly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells

Bayramoğlu

Bitirim

Tunalı

et al. 2013

Materials Science and Engineering: C

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Keywords: Hydrogels biocompatible polymers contact angle blood cell adhesion hemolysis rat mesenchymal stem cells Copolymerization of 2-hydroxyethylmethacrylate (HEMA) with glycidylmethacrylate (GMA) in the presence of α-α′-azoisobisbutyronitrile (AIBN) resulted in the formation of hydrogel films carrying reactive epoxy groups. Thirteen kinds of different molecules with pendant \NH 2 group were used for modifications of the p(HEMA-GMA) films. The \NH 2 group served as anchor binding site for immobilization of functional groups on the hydrogel film via direct epoxy ring opening reaction. The modified hydrogel films were characterized by FTIR, and contact angle studies. In addition, mechanical properties of the hydrogel films were studied, and modified hydrogel films showed improved mechanical properties compared with the non-modified film, but they are less elastic than the non-modified film. The biological activities of these films such as platelet adhesion, red blood cells hemolysis, and swelling behavior were studied. The effect of modified hydrogel films, including \NH 2 , (using different aliphatic \CH 2 chain lengths) \CH 3 , \SO 3 H, aromatic groups with substituted \OH and \COOH groups, and amino acids were also investigated on the adhesion, morphology and survival of rat mesenchymal stem cells (MSCs). The MTT colorimetric assay reveals that the p(HEMA-GMA)-GA-AB, p(HEMA-GMA)-GA-Phe, p(HEMA-GMA)-GA-Trp, p(HEMA-GMA)-GA-Glu formulations have an excellent biocompatibility to promote the cell adhesion and growth. We anticipate that the fabricated p(HEMA-GMA) based hydrogel films with controllable surface chemistry and good stable swelling ratio may find extensive applications in future development of tissue engineering scaffold materials, and in various biotechnological areas.

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“…Perhaps the most important challenge is to understand how to reduce biofouling in implanted sensors. The mechanism of biofouling of implanted systems seems to be related to the denaturation of extracellular matrix proteins, which triggers the inflammatory cascade (73). Materials should be designed to stop or inhibit this initial step.…”

Section: Opportunities For Materials Science In Biomedical Sensingmentioning

confidence: 99%

“…Finally, it is important to acknowledge some issues that may arise with CPs, such as concerns over thermal and chemical stability, the mechanical ruggedness, and tolerance to high-field electric fields of CPs (73,142), all of which may affect the performance of CP-based sensors. Recent research has focused on finding solutions to some of these issues, and the electrochemical growth of CPs in new media like ILs, as highlighted previously, has offered some improvements.…”

Section: Introducing Conducting Polymersmentioning

confidence: 99%