Electroconductive copolymer EDOT-pyrrole for intracellular recording experiments in Helix aspersa neurons

Martínez-Cartagena, Manuel Eduardo; Bernal-Martínez, Juan; Román-Aguirre, Manuel; Aguilar-Elguézabal, A.

doi:10.1016/j.mtchem.2023.101454

Cited by 1 publication

(2 citation statements)

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“…For example, Tian enhanced the electrode with PU-PEDOT: PSS hydrogel, and a subsequent analysis of spike electrical signals revealed that the maximal amplitude intensity at the recording sites of the PU-PEDOT:PSS interface-modified electrode exceeded that of the PEDOT:PSS interface-modified electrode by 1.63 times, while the mean electrical signal amplitude increased from 55 µV to 78 µV [43]. Martinez-Cartagena et al recorded neuronal cell electrical signals using EDOT-pyrrole-coated electrodes, demon-strating that the altered electrodes exhibited heightened sensitivity to bioelectrical signals with a superior SNR and nearly double the signal amplitude compared to conventional Ag/AgCl electrodes [44]. This highlights the efficacy of modifying the surface of implanted electrodes with enhancers in altering the compatibility of the electrode surface with biological tissues and enhancing the electrode's capacity to capture physiological electrical signals.…”

Section: Discussionmentioning

confidence: 99%

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Advancing the Frontiers of Neuroelectrodes: A Paradigm Shift towards Enhanced Biocompatibility and Electrochemical Performance

Wang,

Liu,

Zhang

et al. 2024

Polymers

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The aim of this study is the fabrication of unprecedented neuroelectrodes, replete with exceptional biological and electrical attributes. Commencing with the synthesis of polyethylene glycol and polyethyleneimine-modified iron oxide nanoparticles, the grafting of Dimyristoyl phosphatidylcholine was embarked upon to generate DMPC-SPION nanoparticles. Subsequently, the deposition of DMPC-SPIONs onto a nickel–chromium alloy electrode facilitated the inception of an innovative neuroelectrode–DMPC-SPION. A meticulous characterization of DMPC-SPIONs ensued, encompassing zeta potential, infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction analyses. Evaluations pertaining to hemolysis and cytotoxicity were conducted to ascertain the biocompatibility and biosafety of DMPC-SPIONs. Ultimately, a comprehensive assessment of the biocompatibility, electrochemical properties, and electrophysiological signal acquisition capabilities of DMPC-SPION neuroelectrodes was undertaken. These findings conclusively affirm the exemplary biocompatibility, electrochemical capabilities, and outstanding capability in recording electrical signals of DMPC-SPION neuroelectrodes, with an astounding 91.4% augmentation in electrode charge and a noteworthy 13% decline in impedance, with peak potentials reaching as high as 171 μV and an impressive signal-to-noise ratio of 15.92. Intriguingly, the novel DMPC-SPION neuroelectrodes herald an innovative pathway towards injury repair as well as the diagnosis and treatment of neurological disorders.

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Section: Discussionmentioning

confidence: 99%

“…( B ) Comparison of CV curves for different modifiers. ( C ) Comparison of capacity to capture physiological electrical signals [ 6 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Figurementioning

confidence: 99%