Electrocochleography and Intranasal Allergen Challenge as Investigational Tools in Patients With Inhalant Allergy and Ménière's Disease

Eaton, Debbie; Roland, Peter S.; Mabry, Richard L.; Shoup, Angela G.

doi:10.1097/00005537-200301000-00006

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…In response to our third question (“How does the hearing or vestibular system respond to treatment of allergic diseases in comorbid patients?”), we found evidence that systemic allergic provocation induces cochlear fluid changes in MD patients consistent with endolymphatic hydrops ( 41 , 42 , 44 , 45 , 74 ). Interestingly, some but not all MD patients responded to the allergic provocation test with vertigo and a sense of fullness in the cochlea ( 46 ).…”

Section: Discussionmentioning

confidence: 62%

A systematic review of the clinical evidence for an association between type I hypersensitivity and inner ear disorders

Zeng,

Domarecka,

Kong

et al. 2024

Front. Neurol.

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Inner ear disorders have a variety of causes, and many factors can contribute to the exacerbation of cochlear and vestibular pathology. This systematic review aimed to analyze clinical data on the coexistence and potential causal interaction between allergic diseases and inner ear conditions. A search of PubMed and Web of Science identified 724 articles, of which 21 were selected for full-text analysis based on inclusion and exclusion criteria. The epidemiologic evidence found overwhelmingly supports an association between allergic disease and particular inner ear disorders represented by a high prevalence of allergic reactions in some patients with Ménière’s disease (MD), idiopathic sudden sensorineural hearing loss (ISSHL), and acute low-tone hearing loss (ALHL). In addition, patients with MD, ISSHL, and ALHL had higher levels of total serum IgE than healthy subjects. Finally, in some cases, changes in cochlear potential may have been induced by antigen exposure, while desensitization alleviated allergy and inner ear-related symptoms. The exact mechanism of interaction between the auditory/vestibular and immune systems is not fully understood, and further clinical and basic research is needed to understand the relationship between the two systems fully.

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Section: Discussionmentioning

confidence: 62%

A systematic review of the clinical evidence for an association between type I hypersensitivity and inner ear disorders

Zeng,

Domarecka,

Kong

et al. 2024

Front. Neurol.

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“…Patients report a variety of triggers, including environmental allergen exposure. The prevalence of inhalant allergy is considerably higher in patients with Meniere's disease compared to controls [17, 18], and changes in electrocochleography, an objective measure of cochlear fluid retention, pathognomonic for Meniere's Disease, have been observed following an inhalant allergy challenge in atopic Meniere's patients [19]. Elevated IgE levels in response to mold are present in patients with idiopathic sudden sensorineural hearing loss [20], although we have not identified similar IgE elevations by CAPRAST testing in a subset of our patients (not shown).…”

Section: Introductionmentioning

confidence: 99%

Innate Immune Recognition of Molds and Homology to the Inner Ear Protein, Cochlin, in Patients with Autoimmune Inner Ear Disease

et al. 2013

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Autoimmune Inner Ear Disease (AIED) is characterized by bilateral, fluctuating sensorineural hearing loss with periods of hearing decline triggered by unknown stimuli. Here we examined whether an environmental exposure to mold in these AIED patients is sufficient to generate a pro-inflammatory response that may, in part, explain periods of acute exacerbation of disease. We hypothesized that molds may stimulate an aberrant immune response in these patients as both several Aspergillus species and penecillium share homology with the LCCL domain of the inner ear protein, cochlin. We showed the presence of higher levels of anti-mold IgG in plasma of AIED patients at dilution of 1:256 (p=0.032) and anti-cochlin IgG 1:256 (p=0.0094 and at 1:512 p=0.024) as compared with controls. Exposure of peripheral blood mononuclear cells (PBMC) of AIED patients to mold resulted in an up-regulation of IL-1β mRNA expression, enhanced IL-1β and IL-6 secretion, and generation of IL-17 expressing cells in mold-sensitive AIED patients, suggesting mold acts as a PAMP in a subset of these patients. Naïve B cells secreted IgM when stimulated with conditioned supernatant from AIED patients’ monocytes treated with mold extract. In conclusion, the present studies indicate that fungal exposure can trigger autoimmunity in a subset of susceptible AIED patients.

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Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy

Xu,

Li,

Song

et al. 2023

Clin Exp Med

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Electrocochleography and Intranasal Allergen Challenge as Investigational Tools in Patients With Inhalant Allergy and Ménière's Disease

Cited by 4 publications

References 7 publications

A systematic review of the clinical evidence for an association between type I hypersensitivity and inner ear disorders

A systematic review of the clinical evidence for an association between type I hypersensitivity and inner ear disorders

Innate Immune Recognition of Molds and Homology to the Inner Ear Protein, Cochlin, in Patients with Autoimmune Inner Ear Disease

Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy

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