Electrocochleography: A Review of Recording Approaches, Clinical Applications, and New Findings in Adults and Children

Ferraro, John A.

doi:10.3766/jaaa.21.3.2

Cited by 54 publications

(57 citation statements)

References 36 publications

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“…16 While ECOG is a clinically accepted routine, it is often poorly interpreted in a Meniere's population, where there is a significant hearing loss. 1,13,26,28 In general, ECOG sensitivity does not seem to be more than 67%. 7 A better measure for the vestibular state would directly measure the dynamic response of the vestibular system to both excitatory and inhibitory inputs, and derive a measure of its dynamic range.…”

Section: Introductionmentioning

confidence: 89%

Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere’s Disease

Dastgheib

Lithgow

Blakely³

et al. 2015

Ann Biomed Eng

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In this paper, we report on a new method for assisting in Meniere's disease diagnosis. An accurate diagnosis of Meniere's is challenging, and requires an expert opinion after observing several clinical assessments and tests over a period of time. Our proposed method is based on the analysis of the spontaneous and driven ear evoked responses recorded using Electrovestibulography (EVestG). We used the EVestG signals of 35 individuals suspected of Meniere's and 26 age-matched healthy controls, out of which data of 14 patients with Meniere's and 16 healthy controls were used for developing the diagnostic algorithm (training set) and the rest for testing. While recording and analyzing the test dataset, the researchers were only aware the patients suffered some dizziness, and were kept blind to the exact diagnoses till the end of study. EVestG field potentials (FPs) and their firing pattern, in response to several whole body tilt stimuli from both left and right ears were extracted. We investigated several features of the extracted FPs in response to each of side, back/forward, rotation, up/down, supine rotation, and supine up/down tilt stimulations, and selected the top five features showing the most significant differences between of the groups of the training set for every tilt. An ad-hoc average voting classifier was designed based on building five single-feature classifiers (using Linear Discriminant analysis) and taking the average of the single-feature classifiers' votes. The results showed the side tilt data were best for the purpose of Meniere's diagnosis; it resulted in 78% and 90% sensitivity and specificity for test dataset, respectively. The second best accuracy was achieved using back/forward tilt. The results and their implications are discussed. Overall, the EVestG side tilt results encourage the use of vestibular response as a non-invasive, robust and quick screening for Meniere's and separating it from other types of dizziness.

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Section: Introductionmentioning

confidence: 89%

Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere’s Disease

Dastgheib

Lithgow

Blakely³

et al. 2015

Ann Biomed Eng

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“…The electrode setup and the recording parameters that we used in this study were based upon the study reported by Ferraro [16] . The ground electrode was placed on the forehead (Fz), the active electrode was placed on the eardrum, and the reference electrode was placed on the contralateral mastoid.…”

Section: Stimulus and Recording Parametersmentioning

confidence: 99%

“…The SP/AP amplitude ratio and SP/AP area ratio were based on Ferraro [16] . The SP and the AP amplitudes were measured from the waveform peak and compared to the pre-stimulus baseline (Figure 1).…”

Section: Sp/ap Amplitude Ratio and Sp/ap Area Ratio Calculationmentioning

confidence: 99%

Ear Fullness as a Symptom of Endolymphatic Hydrops in non-Ménière’s Patient

Maheu

Alhabib²,

Landry

et al. 2017

Int Adv Otol

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OBJECTIVE: 1) To determine if unexplained ear fullness might be a symptom of endolymphatic hydrops (EH) by using Electrocochleography (ECochG) SP/AP area and amplitude ratios. 2) To assess if individuals with unexplained ear fullness without vertigo differ significantly from individuals with ear fullness due to Ménière's disease (MD). MATERIALS and METHODS:In a case-control study in our tertiary care center, we evaluated 62 ears across 49 patients, including 18 normal healthy ears across 12 control patients, 26 ears with unexplained ear fullness across 20 patients (6 had bilateral symptoms of ear fullness), and 18 ears with definite MD across 17 patients (1 bilateral disease). Outcome measures were SP/AP amplitude and area ratio, hearing threshold, and air-bone gap. RESULTS:The analysis of auditory thresholds revealed a significant group effect for air conduction [F(2,50)=49.627; p<0.001] and for bone conduction [F(2,50)=45.625; p<0.001]. We observed significant differences between MD (36.36±4.87) and control patients (19.85±2.55) (p=0.015) for amplitude ratio. Moreover, significant differences were noted between MD (5.32±1.06) and controls (1.36±0.07) (p=0.035) and between ear fullness (5.16±1.17) and controls (p=0.026) for the area ratio parameter. No significant correlation was observed between SP/AP area or amplitude ratios and air-bone gap at any of the tested frequencies. The amplitude ratio was not significantly different between the ear fullness and control groups (p=0.406). The area and amplitude ratios did not reveal significant differences between MD and ear fullness (p=1.00). CONCLUSION:EH can be present even in the absence of vertigo and when patients report unexplained ear fullness. This study, to our knowledge, is the first to possibly allow early identification of cochlear EH in patients suffering from ear fullness without vertigo.

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“…Electromagnetic interference can be a major problem in CMW measurements as it can contaminate CMW measurements and can be difficult to avoid. However, the use of appropriate shielding may prevent CMW responses from being contaminated (Ferraro 2010). A low signal to noise ratio is another great challenge for CMWs measured at the concha.…”

Section: Limitations For the Use Of Cmwsmentioning

confidence: 99%

“…However, it is difficult to measure cochlear microphonics (CMs) by using narrowband frequencies in most clinics, because the conventional approach uses broadband frequencies such as a click in the electrocochleogram (ECoG) (Ferraro 2010). The click is much more transient in time and much broader in frequency than the stimulus used in tone burst ABRs and DPOAEs (Zhang & Abbas 1997).…”

Section: Introductionmentioning

confidence: 99%

Using a Concha Electrode to Measure Response Patterns Based on the Amplitudes of Cochlear Microphonic Waveforms Across Acoustic Frequencies in Normal-Hearing Subjects

Zhang

2015

Ear &Amp; Hearing

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We confirmed a measurable CMW response pattern using the concha electrode. We propose that the pattern's features may be partly due to variation along the cochlea of the activities and volume of hair cells and possibly also the physical properties of the basilar membrane. The clinical importance of these results may be related mainly to seven features of the CMW, including electrode locations, response patterns, inclusion of low frequencies, and uniqueness of CMWs (versus otoacoustic emissions, auditory brainstem responses, shorter stimulus, and audiograms). Limitations, such as signal to noise ratio, also exist. After further study, the concha electrode may be used in the clinic and in research, and the response pattern may be used to interpret the CMW measurement.

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Electrocochleography: A Review of Recording Approaches, Clinical Applications, and New Findings in Adults and Children

Cited by 54 publications

References 36 publications

Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere’s Disease

Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere’s Disease

Ear Fullness as a Symptom of Endolymphatic Hydrops in non-Ménière’s Patient

Using a Concha Electrode to Measure Response Patterns Based on the Amplitudes of Cochlear Microphonic Waveforms Across Acoustic Frequencies in Normal-Hearing Subjects

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