Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses

Mir, Lluis M.; Orlowski, Stéphane; Belehradek, Jean; Paoletti, Claude

doi:10.1016/0277-5379(91)90064-k

Cited by 548 publications

(300 citation statements)

References 5 publications

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“…Therapeuticals applications of DNA electrotransfer F André and LM Mir transplanted 21 or spontaneous tumours in mice. 22 Moreover, because of the antitumour efficacy of this approach, clinical trials were rapidly performed.…”

Section: In Vivo Delivery Of Electric Pulsesmentioning

confidence: 99%

DNA electrotransfer: its principles and an updated review of its therapeutic applications

2004

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Section: In Vivo Delivery Of Electric Pulsesmentioning

confidence: 99%

DNA electrotransfer: its principles and an updated review of its therapeutic applications

2004

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“…The anti-tumour effectiveness of bleomycin was shown to be greatly increased by the local delivery of permeabilizing electric pulses at the tumour in preclinical trials with mice Mir et al, 1991). The permeabilizing effect is restricted to an area encompassed by the electrodes.…”

Section: Carcinomamentioning

confidence: 99%

Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy

Mir

Glass²,

Serša³

et al. 1998

Br J Cancer

415

233

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Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy LM Mir', LF Glass23, G Sersa4, J Teissi65, C Domenge6, D Miklavdid7, MJ Jaroszeski38, S Orlowski9, DS Reintgen38, Z Rudolf4, M Belehradek6, R Gilbertl0, M-P Rols5, J Belehradek Jr', JM Bachaud", R DeConti23, B Stabuc4, M Cemazar4, P Coninx'2 and R Heller38 The application of electric pulses to the patients was safe and well tolerated. An instantaneous contraction of the underlying muscles was noticed. Minimal adverse side-effects were observed. ECT was shown to be an effective local treatment. ECT was effective regardless of the histological type of the tumour. Therefore, ECT offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate.

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“…The electric field is caused by high-voltage electric pulses that are delivered to the target tissue (i.e., tumor) using electrodes (Mir et al 1991). ECT is already used in clinical practice for treating metastases of skin melanoma in more than 100 clinical institutions in Europe ) and has already been introduced to clinical trials for treating deep-seated metastases in the liver (Edhemović et al 2011), brain (AgerholmLarsen et al 2011;Linnert et al 2012;Mahmood and Gehl 2011), bone (Fini et al 2011) and soft tissue (Neal et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Planning of Electroporation-Based Treatments Using Web-Based Treatment-Planning Software

et al. 2013

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Electroporation-based treatment combining high-voltage electric pulses and poorly permanent cytotoxic drugs, i.e., electrochemotherapy (ECT), is currently used for treating superficial tumor nodules by following standard operating procedures. Besides ECT, another electroporation-based treatment, nonthermal irreversible electroporation (N-TIRE), is also efficient at ablating deepseated tumors. To perform ECT or N-TIRE of deep-seated tumors, following standard operating procedures is not sufficient and patient-specific treatment planning is required for successful treatment. Treatment planning is required because of the use of individual long-needle electrodes and the diverse shape, size and location of deepseated tumors. Many institutions that already perform ECT of superficial metastases could benefit from treatmentplanning software that would enable the preparation of patient-specific treatment plans. To this end, we have developed a Web-based treatment-planning software for planning electroporation-based treatments that does not require prior engineering knowledge from the user (e.g., the clinician). The software includes algorithms for automatic tissue segmentation and, after segmentation, generation of a 3D model of the tissue. The procedure allows the user to define how the electrodes will be inserted. Finally, electric field distribution is computed, the position of electrodes and the voltage to be applied are optimized using the 3D model and a downloadable treatment plan is made available to the user.

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Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses

Cited by 548 publications

References 5 publications

DNA electrotransfer: its principles and an updated review of its therapeutic applications

DNA electrotransfer: its principles and an updated review of its therapeutic applications

Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy

Planning of Electroporation-Based Treatments Using Web-Based Treatment-Planning Software

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