Electrochemotherapy for digital chondrosarcoma

Shimizu, Takuya; Nikaido, Toshio; Gomyo, Hiroki; Yoshimura, Yasuo; Horiuchi, Akiko; Isobe, Ken‐ichi; Takaoka, Kunio; Ebara, Sohei

doi:10.1007/s007760300043

Cited by 34 publications

(19 citation statements)

References 14 publications

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“…The distribution of the electric field after application of electric pulses by plate or needle electrodes has already been extensively elaborated for small tumor nodules [2]. These settings and electrodes provide efficient treatment of superficial tumor nodules up to 3 cm in diameter in a single electrochemotherapy session and have even been used to treat bone cancer [7-9]. However, to enable treatment of deep-seated tumors, a design of long needle electrodes and in particular their positioning with respect to the tumor is needed.…”

Section: Introductionmentioning

confidence: 99%

Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy

et al. 2010

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BackgroundElectrochemotherapy treats tumors by combining specific chemotherapeutic drugs with an intracellular target and electric pulses, which increases drug uptake into the tumor cells. Electrochemotherapy has been successfully used for treatment of easily accessible superficial tumor nodules. In this paper, we present the first case of deep-seated tumor electrochemotherapy based on numerical treatment planning.MethodsThe aim of our study was to treat a melanoma metastasis in the thigh of a patient. Treatment planning for electrode positioning and electrical pulse parameters was performed for two different electrode configurations: one with four and another with five long needle electrodes. During the procedure, the four electrode treatment plan was adopted and the patient was treated accordingly by electrochemotherapy with bleomycin. The response to treatment was clinically and radiographically evaluated. Due to a partial response of the treated tumor, the metastasis was surgically removed after 2 months and pathological analysis was performed.ResultsA partial response of the tumor to electrochemotherapy was obtained. Histologically, the metastasis showed partial necrosis due to electrochemotherapy, estimated to represent 40-50% of the tumor. Based on the data obtained, we re-evaluated the electrical treatment parameters in order to correlate the treatment plan with the clinical response. Electrode positions in the numerical model were updated according to the actual positions during treatment. We compared the maximum value of the measured electric current with the current predicted by the model and good agreement was obtained. Finally, tumor coverage with an electric field above the reversible threshold was recalculated and determined to be approximately 94%. Therefore, according to the calculations, a small volume of tumor cells remained viable after electrochemotherapy, and these were sufficient for tumor regrowth.ConclusionsIn this, the first reported clinical case, deep-seated melanoma metastasis in the thigh of the patient was treated by electrochemotherapy, according to a treatment plan obtained by numerical modeling and optimization. Although only a partial response was obtained, the presented work demonstrates that treatment of deep-seated tumor nodules by electrochemotherapy is feasible and sets the ground for numerical treatment planning-based electrochemotherapy.Trial registrationEudraCT:2008-008290-54

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Section: Introductionmentioning

confidence: 99%

Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy

et al. 2010

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“…5,6 New indications using ECT have emerged in the medical literature, especially in bone tumors. 7 In our Institute, the Laboratory of Preclinical and Surgical Studies has previously published about ablation of bone cells by electroporation. The results of this study show that electroporation can induce ablation of bone cells without affecting the recovery of osteogenic activity.…”

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confidence: 99%

Electrochemotherapy to Metastatic Spinal Melanoma

Gasbarrini

Campos

Campanacci

et al. 2015

SPINE

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“…It has been used in such a setting before a sphincter-sparing resection of anal melanoma 39 and in digital chondrosarcoma, rescuing the finger from amputation. 40 Furthermore, it could be used to treat basal cell carcinoma on the face with the intent to obtain a cure. Its beneficial antitumour effects have been proved, giving better cosmetic results than excisional surgery.…”

Section: Clinical Usesmentioning

confidence: 99%

Electrochemotherapy in treatment of tumours

Serša

Miklavčič

Čemažar

et al. 2008

European Journal of Surgical Oncology (EJSO)

412

315

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Aim: Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherapy, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of nonpermeant or poorly permeant anticancer drugs with high intrinsic cytotoxicity, such as bleomycin or cisplatin, at the site of electric pulse application. Methods: An overview of preclinical and clinical studies is presented, and the treatment procedure is further critically evaluated. Results: In clinical studies electrochemotherapy has proved to be a highly efficient and safe approach for treating cutaneous and subcutaneous tumour nodules. The treatment response for various tumours (predominantly melanoma) was w75% complete and 10% partial response of the treated nodules. Conclusions: Electrochemotherapy is a new, clinically acknowledged method for the treatment of cutaneous and subcutaneous tumours. Its advantages are high effectiveness on tumours with different histologies, simple application, minimal side effects and the possibility of effective repetitive treatment.

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Electrochemotherapy for digital chondrosarcoma

Cited by 34 publications

References 14 publications

Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy

Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy

Electrochemotherapy to Metastatic Spinal Melanoma

Electrochemotherapy in treatment of tumours

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