Electrochemotherapy for a cutaneous squamous cell carcinoma in a Vietnamese pot-bellied Pig (Susscrofa)

Weissman, M.; Donnelly, Lindsay L.; Branson, Keith; Glahn, Anastasia; Nagy, Dusty W.; Havis, Brett; Johnson, Gayle C.; Flesner, Brian K.

doi:10.1053/j.jepm.2020.03.013

Cited by 3 publications

(15 citation statements)

References 24 publications

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“…While ECT is nowadays regularly used in cats, dogs, and equines, patients from a varied spectrum of other species have also been treated successfully, among them: ferrets ( 81 ), elephants, fishes, turtles ( 82 , 83 ), hedgehogs ( 84 ), snakes ( 85 ), birds ( 86 , 87 ), pigs ( 88 ), among others.…”

Section: Discussion: the Use Of Ect In Veterinary Practicementioning

confidence: 99%

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Tellado¹,

Mir

Maglietti

2022

Front. Vet. Sci.

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Electrochemotherapy (ECT) consists in the application of electric pulses to increase chemotherapeutic drug intake (bleomycin, cisplatin, or calcium) into the tumor cells. It has become a very valuable treatment option in veterinary oncology. It is an effective and safe treatment modality, which is not only beneficial as a palliative treatment, but also for a curative approach. Performing the treatment adequately will ensure the best results possible, in the minimum number of sessions, and reduce complications. Usually, only one session is enough to achieve excellent results, but the treatment can be repeated. Several sessions can be necessary in the case of incompletely treated or very extended lesions, as well as in the occurrence of new lesions. ECT is effective for superficial or oral tumors of any histology that are accessible to the electrodes. Intravenous bleomycin is the preferred drug and route of administration, leaving other ways of administration and drugs for selected cases. The guidelines presented here are destined to veterinarians who want to develop their understanding of the basis of ECT and wish to perform it adequately and effectively. In this paper, we also discuss common problems and how to solve them, and we include practical tips to improve the treatment results based on common questions and mistakes of beginner users.

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Section: Discussion: the Use Of Ect In Veterinary Practicementioning

confidence: 99%

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Tellado¹,

Mir

Maglietti

2022

Front. Vet. Sci.

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“…Electrochemotherapy (ECT) is a local therapy that uses electric current concurrently with cytotoxic drugs. Chemotherapeutics such as bleomycin or cisplatin can be administered intralesionally or systemically 2 . By exposing neoplastic cells to short, high‐intensity electric fields, transmembrane permeability and cellular uptake of cytotoxic agents is transiently augmented, thus significantly increasing their cytotoxic potential.…”

Section: Introductionmentioning

confidence: 99%

“…With increasing numbers of pigs being cared for as pets and increased survival times due to improved husbandry and veterinary care, the possibility of naturally occurring neoplasia is likely to increase in this species. 2 Clinical signs vary with the location and stage of the neoplasm. SCC is an important differential diagnosis for any cutaneous lesion, especially any non-healing, ulcerative lesion located on the nasal planum, pinnae or periocular skin.…”

Section: Introductionmentioning

confidence: 99%

Long‐term management of multifocal, facially oriented squamous cell carcinoma in an American Yorkshire pig with intralesional bleomycin electrochemotherapy, CO₂ laser surgery and cryosurgery

Gould

Stockler

Lindley

et al. 2023

Vet Record Case Reports

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A 4‐year‐old American Yorkshire barrow (Sus scrofa domesticus) presented for masses on the left ventral palpebra and convex pinnae bilaterally. Multiple incisional biopsies were consistent with cutaneous squamous cell carcinoma. The pig was hospitalised for three sessions of electrochemotherapy, with intralesional bleomycin chemotherapy conducted over 1 month. No significant complications from the chemotherapy occurred. Long‐term follow‐up for newly developing lesions on the pinnae and periocular skin included treatment with CO2 laser and cryosurgery with success. Although squamous cell carcinoma is a common finding in food animals, methods other than humane euthanasia for long‐term management of this disease in pigs is poorly documented. Pigs are increasingly becoming popular pet animals, and veterinarians need to consider new modalities and treatment approaches for management of cutaneous neoplasms. This case report describes a comprehensive clinical workup, treatment and long‐term management of squamous cell carcinoma in a domesticated, pet American Yorkshire barrow not intended for food consumption.

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“…2 -4 Oral and cutaneous squamous cell carcinomas have been infrequently reported in pot-bellied pigs kept as pets and may occur in farm pigs as well. 6- 11…”

mentioning

confidence: 99%

“…[2][3][4] Oral and cutaneous squamous cell carcinomas have been infrequently reported in pot-bellied pigs kept as pets and may occur in farm pigs as well. [6][7][8][9][10][11] In animals and humans, including swine, there is an association between squamous cell carcinoma and ultraviolet (UV) light exposure. 9,[12][13][14] This was considered unlikely in this case, as this animal was housed indoors at both the breeding facility and the research facility and thus not exposed to UV light.…”

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confidence: 99%

Mucocutaneous Squamous Cell Carcinoma in a Yucatan Minipig

et al. 2021

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Minipigs are commonly utilized in dermal toxicology studies, necessitating documentation of background findings, including neoplastic lesions. We describe a case of a Yucatan minipig with a squamous cell carcinoma at the mucocutaneous junction of the lip. The neoplasm appeared grossly as a slightly raised area of skin with ulceration. Histologically, there were nests and trabeculae of neoplastic squamous epithelial cells undergoing keratinization. Multifocally, rafts of these cells were within lymphatic vessels. Squamous cell carcinoma has not previously been reported in Yucatan or other laboratory minipigs, however, has been reported uncommonly in nonlaboratory pot-bellied pigs. Although squamous cell carcinoma has been associated with ultraviolet exposure or papillomavirus in various species, this was unable to be confirmed in this case.

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Electrochemotherapy for a cutaneous squamous cell carcinoma in a Vietnamese pot-bellied Pig (Susscrofa)

Cited by 3 publications

References 24 publications

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Long‐term management of multifocal, facially oriented squamous cell carcinoma in an American Yorkshire pig with intralesional bleomycin electrochemotherapy, CO₂ laser surgery and cryosurgery

Mucocutaneous Squamous Cell Carcinoma in a Yucatan Minipig

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Electrochemotherapy for a cutaneous squamous cell carcinoma in a Vietnamese pot-bellied Pig (Susscrofa)

Cited by 3 publications

References 24 publications

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Long‐term management of multifocal, facially oriented squamous cell carcinoma in an American Yorkshire pig with intralesional bleomycin electrochemotherapy, CO2 laser surgery and cryosurgery

Mucocutaneous Squamous Cell Carcinoma in a Yucatan Minipig

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Long‐term management of multifocal, facially oriented squamous cell carcinoma in an American Yorkshire pig with intralesional bleomycin electrochemotherapy, CO₂ laser surgery and cryosurgery