Electrochemiluminescent immunosensor for detection of carcinoembryonic antigen using luminol-coated silver nanoparticles

Nakhjavani, Sattar Akbari; Khalilzadeh, Balal; Afsharan, Hadi; Hosseini, Nashmin; Ghahremani, Mohammad Hossein; Carrara, Sandro; Omidi, Yadollah

doi:10.1007/s00604-023-05656-8

Cited by 9 publications

(2 citation statements)

References 46 publications

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“…[142,143,183,184] This immobilization route confers high efficiency on the sensor, and it is still used in bio-similarity assessment and drug discovery. This approach was explored in work by Nakhjavani et al [185] who developed an electrochemiluminescent (ECL) sandwich immu-nosensor for the detection of carcinoembryonic antigen (CEA). The streptavidin/biotin binding was employed to bind the capture Ab to the AuNPs-modified GCE and to load the detection Ab and the HRP enzyme on luminol-modified AgNPs to perform the immunoassay.…”

Section: Site-direct Approachmentioning

confidence: 99%

“…This immobilization route confers high efficiency on the sensor, and it is still used in bio‐similarity assessment and drug discovery. This approach was explored in work by Nakhjavani et al [185] . who developed an electrochemiluminescent (ECL) sandwich immunosensor for the detection of carcinoembryonic antigen (CEA).…”

Section: Antibody Immobilization Strategies On Npsmentioning

confidence: 99%

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Nanoparticles in Electrochemical Immunosensors – A Concept and Perspective

Polli,

Simonetti,

Surace

et al. 2023

ChemElectroChem

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Nanoparticle‐based electrochemical immunosensors are fascinating and promising screening systems that rely on the affinity binding between antibodies and antigens, allowing the specific detection of diverse types of targets (e. g., proteins, hormones, antibodies). The employment of nanoparticles in the realization of such devices dramatically improves the selectivity, sensitivity, and the transducer surface area for effectively immobilizing the bioreceptor or target molecules. During the last years, the nanoparticles design and fabrication was mainly focused on taking advantage from synergistic effects due to the coupling of different materials. In this review, we summarize the very recent advancements in this regard, with specific emphasis to nanoparticle syntheses procedures, antibody oriented immobilization strategies and transduction techniques. Moreover, the last trends and applications have been extensively discussed along with the remaining challenges and future perspectives.

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Section: Site-direct Approachmentioning

confidence: 99%

Section: Antibody Immobilization Strategies On Npsmentioning

confidence: 99%

Nanoparticles in Electrochemical Immunosensors – A Concept and Perspective

Polli,

Simonetti,

Surace

et al. 2023

ChemElectroChem

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PEG-functionalized black phosphorus quantum dots as stable and biocompatible electrochemiluminescence luminophores for sensitive detection of tumor biomarker

Liu

Sun

et al. 2023

Microchim Acta

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Biosensor-Based Nanodiagnosis of Carcinoembryonic Antigen (CEA): an Approach to Classification and Precise Detection of Cancer Biomarker

Hariri,

Alivirdiloo,

Ardabili

et al. 2023

BioNanoSci.

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The precise detection of cancer biomarkers is a principal aspect of effective diagnosis, monitoring, and therapeutics. Carcinoembryonic antigen (CEA) is a protein normally found in very small amounts in the blood of adults. CEA blood levels can be elevated in benign diseases and certain types of cancer. The CEA test is most commonly used to identify a significantly frequent cancer, colorectal cancer. It has decisive clinical value in monitoring, differential diagnosis, disease, and assessment of therapeutic effects. Therefore, it is important to develop a sensitive and simple CEA detection method to diagnose cancer and improve patient survival accurately. Biosensing has great advantages for early disease detection due to its rapid response, high sensitivity, and convenient operating characteristics. Based on several studies, biosensors seem to be new and promising paths in the future of medical oncology. The main purpose of this study is to introduce and discuss the recent nanodiagnostic biosensors developed since 2018. Therefore, the readers of this study will be introduced to the latest biosensors, the various nanomaterials used in them, and their analytical characteristics. Graphical abstract

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Electrochemiluminescent immunosensor for detection of carcinoembryonic antigen using luminol-coated silver nanoparticles

Cited by 9 publications

References 46 publications

Nanoparticles in Electrochemical Immunosensors – A Concept and Perspective

Nanoparticles in Electrochemical Immunosensors – A Concept and Perspective

PEG-functionalized black phosphorus quantum dots as stable and biocompatible electrochemiluminescence luminophores for sensitive detection of tumor biomarker

Biosensor-Based Nanodiagnosis of Carcinoembryonic Antigen (CEA): an Approach to Classification and Precise Detection of Cancer Biomarker

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