Electrochemiluminescence modified electrodes based on RuSi@Ru(bpy)32+ loaded with gold functioned nanoporous CO/Co3O4 for detection of mycotoxin deoxynivalenol

Lv, Xiaohui; Li, Yueyun; Yan, Tao; Pang, Xuehui; Cao, Wei; Du, Bin; Wu, Dan; Wei, Qin

doi:10.1016/j.bios.2015.03.020

Cited by 30 publications

(13 citation statements)

References 42 publications

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“…Multilayer NPs can perform several functions simultaneously. (Lv et al) (2017) designed RuSi@Ru(bpy)3(2+) loaded with gold-functioned nanoporous CO/Co 3 O 4 electrochemiluminescence biosensors for sensitivity (5 pg/mL) detection of DON [ 40 ]. Ag@Au Core-Shell NPs have been used for surface-enhanced Raman scattering aptasensors for the double detection of OTA A and AFL B1.…”

Section: Mycotoxin Detection Using Nanoparticlesmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The occurrence of mycotoxins in food and feed causes negative health impacts on both humans and animals. Clay binders, yeast cell walls, or antioxidant additives are the most widely used products for mycotoxin elimination to reduce their impact. Although conventional methods are constantly improving, current research trends are looking for innovative solutions. Nanotechnology approaches seem to be a promising, effective, and low-cost way to minimize the health effects of mycotoxins. This review aims to shed light on the critical knowledge gap in mycotoxin elimination by nanotechnology. There are three main strategies: mold inhibition, mycotoxin adsorption, and reducing the toxic effect via nanoparticles. One of the most promising methods is the use of carbon-based nanomaterials. Graphene has been shown to have a huge surface and high binding capacity for mycotoxins. Attention has also been drawn to polymeric nanoparticles; they could substitute adsorbents or enclose any substance, which would improve the health status of the organism. In light of these findings, this review gives new insights into possible future research that might overcome challenges associated with nanotechnology utilization for mycotoxin elimination from agricultural products.

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Section: Mycotoxin Detection Using Nanoparticlesmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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“…However, the signal enhancement is still much lower than that of Ru-SiO 2 @PEI/GCE. This can be explained that both a large amount of Ru(bpy) 3 2+ and its co-reactant PEI were loaded in the Ru-SiO 2 @PEI nanoparticles at the same time so that the electron-transfer distance was shortened, by which the luminous efficiency was enhanced and resulted in the high ECL response 36 . In a word, the prepared Ru-SiO 2 @PEI nanoparticles produced the highest ECL signal by self-enhancement.…”

Section: Resultsmentioning

confidence: 99%

“…Ru(bpy) 3 2+ -doped silica (Ru-SiO 2 ) nanoparticles have attracted much attention due to that each Ru-SiO 2 nanoparticle contained a large amount of Ru(bpy) 3 2+ molecules, which could greatly enhance the ECL signal. The Ru-SiO 2 nanoparticles have been used to construct ECL sensor for DNA analysis 28 29 , immunoassay 30 31 , cell test 32 33 and so on 34 35 36 . Since luminophore itself produce low ECL signal, co-reactant such as tripropylamine (TPA) is usually added to the ECL system to enhance the ECL intensity and improve the analytical performance.…”

mentioning

confidence: 99%

A novel self-enhanced electrochemiluminescence immunosensor based on hollow Ru-SiO2@PEI nanoparticles for NSE analysis

Zhou

Huang

et al. 2016

Sci Rep

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Poly(ethylenimine) (PEI) and Ru(bpy)32+-doped silica (Ru-SiO2) nanoparticles were simply mixed together to prepare a novel self-enhanced electrochemiluminescence (ECL) composite of Ru-SiO2@PEI. The hollow Ru-SiO2@PEI nanoparticles were used to build an ECL immunosensor for the analysis of neuron specific enolase (NSE). PEI not only assembled on the surface of Ru-SiO2 nanoparticles through the electrostatic interaction to act as co-reactant for Ru(bpy)32+ ECL, but also provided alkaline condition to etch the Ru-SiO2 nanoparticles to form the hollow Ru-SiO2@PEI nanoparticles with porous shell. The unique structure of the Ru-SiO2@PEI nanoparticles loaded both a large amount of Ru(bpy)32+ and its co-reactant PEI at the same time, which shortened the electron-transfer distance, thereby greatly enhanced the luminous efficiency and amplified the ECL signal. The developed immunosensor showed a wide linear range from 1.0 × 10−11 to 1.0 × 10−5 mg mL−1 with a low detection limit of 1.0 × 10−11 mg mL−1 for NSE. When the immunosensor was used for the determination of NSE in clinical human serum, the results were comparable with those obtained by using enzyme-linked immunosorbent assay (ELISA) method. The proposed method provides a promising alternative for NSE analysis in clinical samples.

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“…This BLI immunosensor was then modified by the amplification of the assay signal using the primary antibody labeled with colloidal gold [ 35 ]. Lv et al fabricated an sensitive electrochemiluminescence (ECL) immunosensor with RuSi@Ru(bpy) 3 2+ for DON detection [ 43 ]. Nanoporous Co 3 O 4 and Au were used to modify the electrode for electrode-driven luminescence process [ 43 ].…”

Section: Novel Biosensors and Assays Based On Antibodiesmentioning

confidence: 99%

“…Lv et al fabricated an sensitive electrochemiluminescence (ECL) immunosensor with RuSi@Ru(bpy) 3 2+ for DON detection [ 43 ]. Nanoporous Co 3 O 4 and Au were used to modify the electrode for electrode-driven luminescence process [ 43 ].…”

Section: Novel Biosensors and Assays Based On Antibodiesmentioning

confidence: 99%

Advances in Biosensors, Chemosensors and Assays for the Determination of Fusarium Mycotoxins

Lin

Guo

2016

Toxins

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The contaminations of Fusarium mycotoxins in grains and related products, and the exposure in human body are considerable concerns in food safety and human health worldwide. The common Fusarium mycotoxins include fumonisins, T-2 toxin, deoxynivalenol and zearalenone. For this reason, simple, fast and sensitive analytical techniques are particularly important for the screening and determination of Fusarium mycotoxins. In this review, we outlined the related advances in biosensors, chemosensors and assays based on the classical and novel recognition elements such as antibodies, aptamers and molecularly imprinted polymers. Application to food/feed commodities, limit and time of detection were also discussed.

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Electrochemiluminescence modified electrodes based on RuSi@Ru(bpy)32+ loaded with gold functioned nanoporous CO/Co3O4 for detection of mycotoxin deoxynivalenol

Cited by 30 publications

References 42 publications

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

A novel self-enhanced electrochemiluminescence immunosensor based on hollow Ru-SiO2@PEI nanoparticles for NSE analysis

Advances in Biosensors, Chemosensors and Assays for the Determination of Fusarium Mycotoxins

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