Electrochemiluminescence biosensors for detection of cancer biomarkers in biofluids: Principles, opportunities, and challenges

Barhoum, Ahmed; Altıntaş, Zeynep; Devi, K. S. Shalini; Forster, Robert J.

doi:10.1016/j.nantod.2023.101874

Cited by 47 publications

(12 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ensuring the accessibility and affordability of bead-based biosensors is crucial for their global impact, especially in resource-limited settings. Cost-effective fabrication techniques, scalable manufacturing processes, and affordable readout systems are needed to make these biosensors accessible to wide-ranging healthcare settings [16]. Additionally, healthcare professionals should be trained in the use and interpretation of bead-based biosensors to maximize their impact in diverse healthcare settings.…”

Section: Accessibility and Affordabilitymentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

View full text Add to dashboard Cite

Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the versatility, high sensitivity, and flexibility to perform the multiplexing of beads. This comprehensive review highlights recent trends and innovations in the development of bead-based biosensors for cancer-biomarker detection. We introduce various types of bead-based biosensors such as optical, electrochemical, and magnetic biosensors, along with their respective advantages and limitations. Moreover, the review summarizes the latest advancements, including fabrication techniques, signal-amplification strategies, and integration with microfluidics and nanotechnology. Additionally, the challenges and future perspectives in the field of bead-based biosensors for cancer-biomarker detection are discussed. Understanding these innovations in bead-based biosensors can greatly contribute to improvements in cancer diagnostics, thereby facilitating early detection and personalized treatments.

show abstract

Section: Accessibility and Affordabilitymentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

View full text Add to dashboard Cite

show abstract

“…Electrochemiluminescence (ECL) is a process in which light is generated by converting electrical energy through electrochemical redox reactions of substrates and luminophores. − Recently, ECL has been employed as a powerful optical imaging technology due to its distinct merits of having a low background, absence of photothermal effect, persistent luminescence, and high throughput, as well as good spatiotemporal resolution. , These features enable real-time monitoring of individual nanomaterial activities. ECL has been widely used in cell imaging and sensing, optogenetics, immunoassays, DNA detection, and cancer screening. − Due to the aforementioned merits, ECL is a potential light source in PDT.…”

Section: Various Categories Of Light Generation or Delivery Systemsmentioning

confidence: 99%

Beyond External Light: On-Spot Light Generation or Light Delivery for Highly Penetrated Photodynamic Therapy

Cui,

Li,

Peng

et al. 2023

ACS Nano

View full text Add to dashboard Cite

External light sources, such as lasers, light emitting diodes (LEDs) and lamps, are widely applied in photodynamic therapy (PDT); however, their use is severely limited by the nature of shallow tissue penetration depth. The recent exploration of light delivery or local generation on tumor sites has attracted much attention, owing to the fact that these systems are significantly endowed with high tissue penetration. In this review, we briefly introduced the principle of "onspot light generation or delivery systems" in PDT. These systems are divided into different categories: (1) implantable luminescence, (2) mechanoluminescence, (3) electrochemiluminescence, (4) Cerenkov luminescence, (5) chemiluminescence, and (6) bioluminescence. Finally, their applications, advantages, and disadvantages in PDT will be appropriately summarized and further discussed in detail. We believe that this review will provide general guidance for the further design of light generation or delivery systems and clinical studies for PDT-mediated cancer treatments with unparalleled merits.

show abstract

“…In fact, in the early stages of cancer development, changes occur inside the cell that are different from normal cells, such as increased expression of certain sugars, proteins, and hormones, as well as changes in pH, reactive oxygen species (ROS), and viscosity [ 4 , 5 , 6 ]. These substances, produced by malignant tumor cells or other cells in the body in response to conditions such as cancer, are called cancer biomarkers [ 7 , 8 , 9 ]. Therefore, detecting accurately and quantitatively cancer biomarkers is of great value for the early and accurate diagnosis of cancer and for evaluating the effectiveness of treatment in later stages.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

Tian,

Wu,

Xiang

et al. 2024

Molecules

View full text Add to dashboard Cite

Many important biological species have been identified as cancer biomarkers and are gradually becoming reliable targets for early diagnosis and late therapeutic evaluation of cancer. However, accurate quantitative detection of cancer biomarkers remains challenging due to the complexity of biological systems and the diversity of cancer development. Fluorescent probes have been extensively utilized for identifying biological substances due to their notable benefits of being non-invasive, quickly responsive, highly sensitive and selective, allowing real-time visualization, and easily modifiable. This review critiques fluorescent probes used for detecting and imaging cancer biomarkers over the last five years. Focuses are made on the design strategies of small-molecule and nano-sized fluorescent probes, the construction methods of fluorescence sensing and imaging platforms, and their further applications in detection of multiple biomarkers, including enzymes, reactive oxygen species, reactive sulfur species, and microenvironments. This review aims to guide the design and development of excellent cancer diagnostic fluorescent probes, and promote the broad application of fluorescence analysis in early cancer diagnosis.

show abstract

Electrochemiluminescence biosensors for detection of cancer biomarkers in biofluids: Principles, opportunities, and challenges

Cited by 47 publications

References 169 publications

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Beyond External Light: On-Spot Light Generation or Light Delivery for Highly Penetrated Photodynamic Therapy

Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

Contact Info

Product

Resources

About