Electrochemically reduced fullerene–graphene oxide interface for swift detection of Parkinsons disease biomarkers

Rather, Jahangir Ahmad; Khudaish, Emad A.; Munam, Abdul; Qurashi, Ahsanulhaq; Kannan, Palanisamy

doi:10.1016/j.snb.2016.06.137

Cited by 37 publications

(23 citation statements)

References 45 publications

(30 reference statements)

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“…Nanotechnology has been used for both diagnosis and therapeutics of the PD in advance medical studies worldwide [14][15][16]. For PD diagnosis, several nanobiosensors have been developed so far based on the quantification of different biomarkers of PD such as dopamine [17,18], alpha-synuclein protein [19], homovanilic acid [20] and even PD-related genetic mutation [21]. Nanobiosensors comprise the advantages of using nanomaterials and nanostructures in biosensors, especially electrochemical nanobiosensors.…”

Section: Introductionmentioning

confidence: 99%

“…There are many reports regarding the positive effect of the application of nanotechnology for enhancing the sensitivity of electrochemical nanobiosensors [22][23][24][25]. For the electrochemical nanobiosensor of PD detection, scientists have used different nanoparticles or nanostructures, such as single-walled carbon nanotubes [18], multi-walled carbon nanotubes [26], gold nanoparticles [27], graphene [17], graphene oxide nanoribbons [28], electrochemically reduced fullerene-graphene oxide [20], etc.…”

Section: Introductionmentioning

confidence: 99%

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A highly sensitive miR-195 nanobiosensor for early detection of Parkinson’s disease

Aghili

Nasirizadeh

Divsalar

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Early detection of Parkinson's disease (PD), as a dangerous neurodegenerative disease, is a key factor in the therapy or prevention of further development of this disease. We developed an electrochemical nanobiosensor for early detection of PD based on the quantification of circulating biomarker, miR-195. Exfoliated graphene oxide (EGO) and gold nanowires (GNWs) were used to modify the surface of screen-printed carbon electrode. A single-strand thiolated probe was designed for specific hybridization with target miRNA (miR-195), and doxorubicin was used as an electrochemical indicator for differential pulse voltammetry measurements. The results of scanning electron microscope imaging and cyclic voltammetry experiments confirmed the accuracy of the working electrode modification steps. The results of analytical performance nanobiosensor showed a high sensitivity of the biosensing with 2.9 femtomolar detection limit and dynamic range of 10.0-900.0 femtomolar. In addition, good selectivity for target miRNA over non-specific oligonucleotides (one and three base replacement in target miRNA, and non-complementary) was achieved. The results of real human serum analysis did not show any interference in the function of the biosensor. Based on the results, the miR-195 electrochemical nanobiosensor could be suggested for clinicians in the medical diagnosis of PD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A highly sensitive miR-195 nanobiosensor for early detection of Parkinson’s disease

Aghili

Nasirizadeh

Divsalar

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…These flakes are strongly modified during the GO production. Figure 5(b) shows crumpled-and wrinkled-layer morphologies of GO where it is possible to observe the edges of individual sheets [54]. On the other hand, Figure 5(c) displays a creased and disintegrated morphology of TERGO with finer and more defined sheets that were randomly aggregated [55].…”

Section: Morphological and Microstructural Characterizationmentioning

confidence: 98%

Functionality of TERGO Powders during the Synthesis of PANI-Based Composites for Electrical Devices

Domínguez‐Crespo

López‐Oyama

Torres‐Huerta

et al. 2019

Journal of Nanomaterials

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In this work, hybrid composites were prepared using polyaniline (PANI) and electrochemically reduced graphene oxide (ERGO) by in situ polymerization. ERGO powders were obtained by a two-way route, Hummer's method, and one-step potential (−2 V) followed by annealing process at 400°C (TERGO powders): different quantities of TERGO fine particles (10, 20, and 30 wt%) were added to the in situ PANI polymerization in order to produce the hybrid composites. The morphology and structure of the PANI/TERGO compounds were characterized by Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Thermal treatment of ERGO powders pointed out high-defect surfaces with a wrinkle-type morphology (I D /I G ratio~0.90). The emeraldine phase of PANI was obtained with a maximum value of 61%, which decreases with the amount of TERGO powders. It is also seen that composites displayed a combined morphology between PANI matrix and TERGO powders, confirming a physical interaction between both morphologies. The amount of TERGO particles into the polymeric matrix also modifies the sample microstructure from a semispherical shape to extend sheets, where PANI is sandwiched between TERGO layers. Electrical conductivity of composites slightly increases independent of the TERGO amount (30 S/m and 39 S/m) due to the rough TERGO surface that conditioned the homogeneous nucleation of a large amount of polymer (PANI) reducing the area to move the electrical charge.

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“…Nanohybrid structures involving graphene and fullerene have generated scientific interest due to the enhanced and new synergistic properties and function. Graphene-fullerenebased nanocomposite holds great promise for potential applications in different fields such as nano-electronics, optoelectronics, lasers, nano-mechanics, energy storage, energy conversion, spintronics, catalysis, sensors, cancer therapy and medical biology [23][24][25][26][27][28][29][30]. In the literature some molecular dynamics (MD) and density functional theory (DFT) based simulation studies on the interactions between graphene and fullerene and 2D materials have been reported [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46].…”

Section: Introductionmentioning

confidence: 99%

Simulation of graphene–fullerene nanohybrid structure

Devi

2019

Bull Mater Sci

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In the present simulation study, the structure and dynamics of graphene-fullerene nanocomposite has been investigated using all atom molecular dynamics simulation technique. The formation of graphene-fullerene nanocomposite constituting graphene and self-assembly of 12 bucky balls has been demonstrated. The structure, size, interparticle separation, spatial distribution, temperature effect, mobility and conformation of graphene-fullerene nanocomposite, and the influence of single and two layers of graphene on the structure of graphene-fullerene nanocomposite have been determined and discussed in detail. This simulation result may possibly aid the design and development of graphene-fullerene hybrid nanomaterials for future biological and technological applications.

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Electrochemically reduced fullerene–graphene oxide interface for swift detection of Parkinsons disease biomarkers

Cited by 37 publications

References 45 publications

A highly sensitive miR-195 nanobiosensor for early detection of Parkinson’s disease

A highly sensitive miR-195 nanobiosensor for early detection of Parkinson’s disease

Functionality of TERGO Powders during the Synthesis of PANI-Based Composites for Electrical Devices

Simulation of graphene–fullerene nanohybrid structure

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