Electrochemically modulated liquid chromatography using a boron-doped diamond particle stationary phase

Muna, Grace W.; Swope, Vernon M.; Swain, Greg M.; Porter, Marc D.

doi:10.1016/j.chroma.2008.09.069

Cited by 20 publications

(9 citation statements)

References 57 publications

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“…The introduction of dopants into carbon materials is a useful method of altering their physical and chemical properties. Successful work thus far includes the superior performance of doped carbons in applications such as electrode materials for catalysis [1][2][3] or energy storage, [4][5][6][7][8] stationary phases, 9,10 and chemoselective adsorption. 11,12 The majority of research in this field has focused on nitrogen doping, which is known to induce favorable changes in the carbon material, e.g.…”

Section: Introductionmentioning

confidence: 99%

A one-pot hydrothermal synthesis of tunable dual heteroatom-doped carbon microspheres

et al. 2012

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Section: Introductionmentioning

confidence: 99%

A one-pot hydrothermal synthesis of tunable dual heteroatom-doped carbon microspheres

et al. 2012

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“…Other researchers followed the concept and investigated the separation of inorganic [9-11] and organic compounds [12][13][14]. The Porter group [15][16][17][18][19][20][21], however, carried out a major part of the process's development, studying the retention time of different molecules combined with several resin materials [22,23] and mobile phases [24,25]. Knizia et al [26] and Kocak et al [27] pushed the development of PCC further by extending the process from the analytical to the preparative scale.…”

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confidence: 99%

A Carbon Nanotube Packed Bed Electrode for Small Molecule Electrosorption: An Electrochemical and Chromatographic Approach for Process Description

et al. 2020

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Triggering the interaction of nanomaterials with molecules by means of electrical potentials in aqueous media remains challenging, especially if 3D through-flow systems are used as electrodes, as in potential-controlled liquid chromatography (PCC). In this paper, multi-walled carbon nanotubes (MWCNTs) function as a particulate packed bed electrode in order to study the system’s response to various applied potentials and electrolyte compositions. The process principle was analyzed using chronoamperometry and cyclic voltammetry. Applying an electrical potential to the hydrophilic MWCNTs induces the presence of both capacitive and faradaic currents. This leads, over time, to a degradation of the electrode due to structural changes of the MWCNT matrix and an increase in redox reactions on the surface. The role of the electrochemical double layer (EDL) is highlighted as a main player in the process, directly influencing the adsorption capability of the electrode. The EDL rearrangement time and coverage radius depend on the composition of the mobile phase and on the potential applied. The capacity of the electrode for the target (maleic acid) increases at high positive potentials (+800 mV vs. Ag/AgCl), while the presence of electrolytes leads to a capacity decrease. Our research enhances the understanding of capacitive through-flow cells.

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“…For instance, the specific surface area of the often used glassy carbon is <10 m²/g ; thus, the surface for electroadsorption in the column is too small for an effective chromatography process. Materials such as polypyrrole coatings and boron‐doped diamond powder have other disadvantages when being used as chromatography resins, for example low long‐term stability or excessively high complexity, respectively. In the case of porous graphitic carbon, the price seems to be the main reason it is only used for analytical research .…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotubes-A resin for electrochemically modulated liquid chromatography

2017

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Electrochemically modulated liquid chromatography is a special form of ion exchange chromatography in which the separation process is controlled by applying an electric potential to the stationary phase. This form of chromatography has so far only been applied in research studies. The present study shows that multiwalled carbon nanotubes are an effective resin material for an electrochemically modulated chromatography process. The experiments are carried out in a newly designed column that enables the packing of nanomaterials. We investigate the influence of the applied potential on the retention and elution of maleic acid, determine the dynamic binding capacity, and calculate the utilization degree of the electrical charge in the adsorption process. Moreover, the stability of the resin and the membrane over more than 200 working hours are presented. In addition to the stability, their sturdiness and inexpensive price are important qualities that make multiwalled carbon nanotubes interesting for application as the stationary phase in an electrochemically driven process. The investigated chromatography technique represents a promising separation process for future applications as a preparative step in biotechnology as well as other life science fields.

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Electrochemically modulated liquid chromatography using a boron-doped diamond particle stationary phase

Cited by 20 publications

References 57 publications

A one-pot hydrothermal synthesis of tunable dual heteroatom-doped carbon microspheres

A one-pot hydrothermal synthesis of tunable dual heteroatom-doped carbon microspheres

A Carbon Nanotube Packed Bed Electrode for Small Molecule Electrosorption: An Electrochemical and Chromatographic Approach for Process Description

Carbon nanotubes-A resin for electrochemically modulated liquid chromatography

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