Electrochemically enabled synthesis of sulfide imidazopyridines <i>via</i> a radical cyclization cascade

Zhong, Ping-Fu; Lin, Hong-Min; Wang, Lin-Wei; Mo, Zu‐Yu; Meng, Xiu‐Jin; Tang, Hai‐Tao; Pan, Ying‐Ming

doi:10.1039/d0gc02125c

Cited by 124 publications

(30 citation statements)

References 34 publications

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“…Following investigation of researchers in different fields of organic compounds, [ 20–53 ] here, we are focused on thermodynamic and kinetic aspects of silapyridine, 3 , as well as its fused ring analogues ( 4–12 ), in two singlet ( 4s–12s ) and triplet ( 4t–12t ) states (Scheme 2). Substituent effects of fused aromatic rings on two of sides of silapyridine are coupled with suitable canonical forms and MEP maps.…”

Section: Resultsmentioning

confidence: 99%

A computational perspective of novel N‐heterocyclic silylenes using density functional theory

Hassanpour

Heravi

Nezhad

et al. 2021

J of Physical Organic Chem

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In this theoretical survey, we inspect substituent effects of two fused benzene, pyrrole, phosphole, furan, and thiophene rings on the stability, polarity, charge distribution, nucleophilicity, electrophilicity, and aromaticity of singlet (s) and triplet (t) silylenes, at density functional theory (DFT). Singlet silylenes as ground state exhibit more stability than their corresponding triplet congeners. In contrast to previous reports on Hammick carbenes, here higher thermodynamic stability (singlet‐triplet energy difference or ΔEs‐t = Et − Es) is considered for silylene situated between two sulfur heteroatoms of two substituted thiophene rings, in a “chair” arrangement in the direction of the silylenic center. Regardless of how arranged, the order of stabilizing effect for fused rings is thiophene > furan > pyrrole > phosphole > benzene. The substituted Hammick silylenes with two fused heterocyclic rings show more stability than synthesized silylenes by Denk and Kira. Also, higher kinetic stability (the frontier molecular orbitals energy difference or ΔEHOMO‐LUMO) is revealed by silylene situated between two oxygen heteroatoms of two substituted furan rings, in a “W” arrangement to the divalent center. The scrutinized singlet structures display wider band gap than their triplet states. Every triplet silylene shows higher nucleophilicity (about 1/5 times) than its corresponding singlet state. Commonly, six‐membered aromatic N‐heterocyclic silylenes (NHSis) show higher N and lower ω than that of five‐membered aromatic NHSis. The highest N and the least ω character is anticipated for the substituted pyrrole NHSis in either “W” arrangement or “chair” orientation toward the silylenic center, among the fused species.

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Section: Resultsmentioning

confidence: 99%

A computational perspective of novel N‐heterocyclic silylenes using density functional theory

Hassanpour

Heravi

Nezhad

et al. 2021

J of Physical Organic Chem

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“…Pan and Tang recorded a three‐component reaction starting from vinylazides, pyridines and thiophenols to synthesize thio imidazo[1,2‐a]pyridines 91 via a radical [3+2] cycloaddition under electrochemical conditions (Scheme 23). [64] …”

Section: Multicomponent Reaction Involving Organosulfur Compoundsmentioning

confidence: 99%

Recent Advances in Multicomponent Reactions with Organic and Inorganic Sulfur Compounds

Tang

Yin

Kuchukulla

et al. 2021

The Chemical Record

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In recent years, multicomponent reactions with inorganic and organic sulfur compounds as one of reactants have achieved a remarkable development. In this review, we summarize recent advances in the multicomponent reactions involving sulfur components, which include elemental sulfur, sodium metabisulfite, sodium hyposulfite, potassium pyrosulfite, DABSO, sodium sulfide, thiocyanate, sulfur dioxide, carbon disulfide and other divalent, tetravalent and hexavalent organosulfur compounds.

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“…A brief classification of some optical sensor mentioned above and wide had wide applications in various fields such as healthcare, bio pharmaceutical sectors, security, and food [44,45]. These optical biosensors have been developed successfully the signal-to-noise ratio and improved the detection limit.…”

Section: Surface Enhanced Raman Scatteringmentioning

confidence: 99%

Monitoring Biomaterials with Light: Review of Surface Plasmon Resonance Biosensing Using two Dimensional Materials

Yari¹,

Farmani²,

Farmani³

et al. 2021

Preprint

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The purpose of this paper is to present advanced techniques in optical biodevices. Moreover different configurations involving the generation of fiber optical biosensors are described. To overcome some limitations of fiber optical biosensors, plasmonic phenomena proposed. In addition novel plasmonic phenomena have broaden researcher’s horizons in new discovering in terms of technology and application. As regards there are many challenges to detect ultra-low concentration samples with high sensitivity in real time. Researchers have always made great efforts to discover more effective methods. Throughout the paper SPR and LSPR as a powerful analysis instrument are introduced. Finally surveys the current practical performances of plasmonic sensors in detection of bio target are provided. As a result these devices demonstrate great potential in identifying target analytic due to their unique optical biosensors.

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Electrochemically enabled synthesis of sulfide imidazopyridines via a radical cyclization cascade

Abstract: Owing to the inert nature of the pyridine ring and high activity of iminyl radical, the reaction between pyridine and iminyl radical remains a significant challenge. In this paper, we...

Cited by 124 publications

References 34 publications

A computational perspective of novel N‐heterocyclic silylenes using density functional theory

A computational perspective of novel N‐heterocyclic silylenes using density functional theory

Recent Advances in Multicomponent Reactions with Organic and Inorganic Sulfur Compounds

Monitoring Biomaterials with Light: Review of Surface Plasmon Resonance Biosensing Using two Dimensional Materials

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