Electrochemical α-methoxymethylation and aminomethylation of propiophenones using methanol as a green C1 source

Abstract

Methanol plays a crucial role in organic synthesis as a green C1 source. Herein, the concise α-methoxymeth- ylation and aminomethylation of propiophenones is achieved via electrochemistry with methanol as both...

Homogeneous Catalysis for the Conversion of CO2, CO, CH3OH, and CH4 to C2+ Chemicals via C–C Bond Formation

“…For example, the catalytic reduction of CO 2 to carbon monoxide (CO) or methanol (CH 3 OH) , and C–H bond functionalization of CH 4 to form CH 3 –X (X = BR n , OR) products , have shown great importance in energy conversion. Additionally, catalytic processes involving carboxylation, , carbonylation, , or methylation/methoxylation using CO 2 , CO, or methanol derivatives have been widely adapted in chemical synthesis for the production of complex natural products, agrochemicals, and pharmaceuticals. − This chemistry is seen as an inexpensive and effective way to incorporate renewable building blocks or industrial byproducts into fine chemicals.…”

Magnetic MoS2 efficient heterogeneous photocatalyst for the α-methoxymethylation and aminomethylation of aromatic ketones

“…20 Subsequently, Meng et al described an electrochemical method for this transformation with methanol as both the solvent and reactant using n Bu 4 NBF 4 as an electrolyte and electrons as redox agents. 21 Recently, the visible light-promoted α-methoxymethylation and aminomethylation of ketones have been developed using rose bengal as a photosensitizer (Scheme 1). 22 Despite all the progress achieved by these methods, their environmental footprint is far from ideal.…”

Photo‐Induced C1 Substitution Using Methanol as a C1 Source

“…[2,14,15] In the past decades, a number of methods involving methanol have already been disclosed to replace these traditional C 1 reagents. [16][17][18][19][20][21][22][23][24] Nevertheless, the development of efficient and environmental-friendly transformation methodologies remains highly desirable but challenging. [25][26][27][28] Among the various methods, photochemical strategy is considered as a "renewable" candidate, and has received significant attention in the last half-century.…”

“…In particular, methanol is deemed a multipurpose C 1 source for industrial and synthetic applications [2,14,15] . In the past decades, a number of methods involving methanol have already been disclosed to replace these traditional C 1 reagents [16–24] . Nevertheless, the development of efficient and environmental‐friendly transformation methodologies remains highly desirable but challenging [25–28] …”