Electrochemical synthesis of thin-layered graphene oxide-poly(CTAB) composite for detection of morphine

Abraham, Pinky; Renjini, S; Nancy, T.E. Mary; Kumary, V. Anitha

doi:10.1007/s10800-019-01367-2

Cited by 33 publications

(15 citation statements)

References 37 publications

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“…The LOD/LOQ lower values and wide concentration linear range are a confirmation for the ultrahigh sensitivity of the proposed chemosensor. Furthermore, the LOD/LOQ values were improved than the other published articles previously, − ,,,, and the comparison is summarized in Table S3.…”

Section: Results and Discussionmentioning

confidence: 70%

“…Morphine (MOR), one of the most common opioid family members, is derived from the sap of the poppy plant . Clinically, MOR is known as the benchmark or gold standard analgesic and one of the best analgesic drugs because of its ability to relieve pain (from moderate to severe pain) in patients of cancer, nonmalignant pain, or undergoing surgical procedures. − Therefore, the World Health Organization (WHO) recommended it as the best opioid drug for pain relief, especially for cancer patients and is commonly used in the USA, UK, some European countries, and worldwide . It is also used as the starting material for synthetic opioid drugs as oxymorphine, hydromorphine, and heroin .…”

Section: Introductionmentioning

confidence: 99%

“…About 90% of the MOR dose is excreted within 24 h in urine and contains about 10% in the unmetabolized form . The overdose of MOR is toxic and can affect many immune functions and cause a significant disturbance in the central nervous system, blood pressure, and respiratory rate. , …”

Section: Introductionmentioning

confidence: 99%

“…Many analytical techniques and methodologies were used for MOR detection and quantification such as high-performance liquid chromatography, surface plasma resonance, immunochromatographic assay, fluorescence immunoassays, spectrophotometric method, chemiluminescence, surface-ionization mass spectrometry, and electrochemical methods. − ,, More details about the MOR sensors and detection have been discussed in reference reviews. ,, Although the mentioned methods can offer many advantages, but also have limitations, they frequently require technical expertise, high infrastructure, pretreatment sample steps, are time-consuming, and/or costly. In addition, till date, based on our knowledge, there is no published work for the detection of MOR in terms of used metal–organic framework (MOF) materials.…”

Section: Introductionmentioning

confidence: 99%

“…7 The overdose of MOR is toxic and can affect many immune functions and cause a significant disturbance in the central nervous system, blood pressure, and respiratory rate. 1,2 In general, MOR is an abused drug without medical recommendation. In sports, it is one of the prohibited doping drugs, and the administration of MOR by athletes is banned from a lot of important organizations such as the International Olympic Committee (IOC) and by the World Anti-Doping Agency (WADA).…”

Section: ■ Introductionmentioning

confidence: 99%

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Dual Naked-Eye and Optical Chemosensor for Morphine Detection in Biological Real Samples Based on Cr(III) Metal–Organic Framework Nanoparticles

Alhaddad

Sheta

2020

ACS Omega

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The analytical detection and quantification of abuse drugs such as morphine (MOR) in biological samples are vital missions and remains to attract challenges for forensic toxicology, law enforcement, world antidoping organization, and social health fields. MOR, a benchmark analgesic drug known as "pain killer", is one of the powerful opioid medications for relieving pain, and overdose of MOR is toxic. In this article, novel promising chromium metal−organic framework nanoparticles [Cr(III)-MOF-NPs] were produced via facile synthesis and characterized using high-resolution transmission electron microscopy, field-emission scanning electron microscopy/energy-dispersive X-ray spectroscopy, mass spectrometry, X-ray photoelectron spectroscopy, elemental analysis, UV−vis, Fourier transform infrared, and thermogravimetry/differential scanning calorimetry, as well as photoluminescence (PL) investigation and magnetic properties. The PL study results revealed that the Cr(III)-MOF-NPs exhibited an emission band at 593 nm. The Cr(III)-MOF-NPs could be used in fast, selective, and sensitive MOR detection and quantification. Under the optimum experimental conditions, with the addition of MOR, a blueshift from 593 to 566 nm occurred with a remarkable PL intensity enhancement, and the color changed from brown to yellow (visually/naked-eye detection). The Cr(III)-MOF-NPs optical chemosensor exhibited a stable response for MOR in a concentration range between 0.1 and 350 nM. The detection and quantification limits were 0.167 and 0.443 nM, respectively, with a correlation coefficient (r 2 ) of 0.96. The developed PL chemosensor showed high selectivity for MOR over other competing interfering matrices. Moreover, the ultrasensitive chemosensor was extensively used for the determination of MOR spiked in different real samples (serum and urine samples) with acceptable recoveries and satisfactory results.

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