Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

Abstract

<p>Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives.</p>

Apoptosis oxidative damage‐mediated and antiproliferative effect of selenylated imidazo[1,2‐a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo

“…On the other hand, organoselenium compounds have attracted considerable attention among chemical and biochemical researchers due to their biological properties, such as cardiovascular protection, anticancer, antivirus, and anti‐Alzheimer activity. [ 18–20 ] Recent evidence has shown the importance of this class of compounds in cancer chemotherapy. [ 21,22 ] Chakraborty et al [ 23 ] showed that therapy with organoselenium compounds may occur through reactive oxygen species (ROS)‐induced p53 activation and mitochondria‐mediated caspase‐dependent apoptosis.…”

Selenylated-oxadiazoles as promising DNA intercalators: Synthesis, electronic structure, DNA interaction and cleavage

“…As part of our continuing research interest in the synthesis of biologically relevant organoselenium compounds [36][37][38] and material chemistry [39][40][41][42], herein we report the synthesis of selenylated-ODZ, their characterization, DNA interaction, and plasmid DNA cleavage activity. Furthermore, the photophysical, thermal and electrochemical properties of the selenylated products were explored and were also supported by theoretical studies.…”

Synthesis of 2,1,3-Benzoxadiazole Derivatives as New Fluorophores—Combined Experimental, Optical, Electro, and Theoretical Study

“…As part of our continued involvement in the chemistry of Nheterocycles (Saba et al, 2015(Saba et al, , 2016(Saba et al, , 2017(Saba et al, , 2018(Saba et al, , 2020Rafique et al, 2016Rafique et al, , 2018aSilva et al, 2017;Bettanin et al, 2018;Peterle et al, 2018;Rodigues et al, 2018;Tornquist et al, 2018;Meirinho et al, 2019;Neto et al, 2020;Scheide et al, 2020) and material sciences (Frizon et al, 2014(Frizon et al, , 2015(Frizon et al, , 2016(Frizon et al, , 2018Bo et al, 2016Bo et al, , 2018Westrup et al, 2016;Matzkeit et al, 2018;Regis et al, 2018), herein, we report the synthesis and characterization of BOX derivatives containing electrondonor groups (alkylated tetrazole rings) connected to the 2,1,3-BOX group as an electron-acceptor unit. In addition, thermal, electrochemical, and theoretical predictions were made and photophysical analysis was performed to study the stability, likely geometry, and luminescence properties of these compounds in their ground and excited electronic states.…”