Electrochemical Synthesis of Fluorinated Orthoesters from 1,3‐Benzodioxoles

As the breadth of radical chemistry grows, new means to promote and regulate single-electron redox activities play increasingly important roles in driving modern synthetic innovation. In this regard, photochemistry and electrochemistry—both considered as niche fields for decades—have seen an explosive renewal of interest in recent years and gradually have become a cornerstone of organic chemistry. In this Outlook article, we examine the current state-of-the-art in the areas of electrochemistry and photochemistry, as well as the nascent area of electrophotochemistry. These techniques employ external stimuli to activate organic molecules and imbue privileged control of reaction progress and selectivity that is challenging to traditional chemical methods. Thus, they provide alternative entries to known and new reactive intermediates and enable distinct synthetic strategies that were previously unimaginable. Of the many hallmarks, electro- and photochemistry are often classified as “green” technologies, promoting organic reactions under mild conditions without the necessity for potent and wasteful oxidants and reductants. This Outlook reviews the most recent growth of these fields with special emphasis on conceptual advances that have given rise to enhanced accessibility to the tools of the modern chemical trade.

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New Redox Strategies in Organic Synthesis by Means of Electrochemistry and Photochemistry

Liu

et al. 2020

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Electrochemical Method: A Green Approach for the Synthesis of Organic Compounds

Garg

Sohal

Malhi

et al. 2022

COC

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Background: Heterocyclic compounds have gained attention due to their growing demand against various infectious diseases, but their synthesis with hazardous chemicals, costly catalysts, and costly purification methods encourage researchers to explore alternative sources. The electrochemical method offers a powerful and versatile approach for assembling different heterocyclic structures. Moreover, it gives a highly proficient and green methodology that avoids harmful oxidants and reductants. Objective: In this review, we aim to compile the different types of reaction i.e. Curtin-Hammet, Michael addition, Wittig reaction, Henry, Diels-Alder, Friedel-crafts, Kolbe, Heck, Benzoin condensation reaction taking place in case of electrochemical synthesis in the last 3 years from 2017-2020. So, to the best of our knowledge, after 2017 there is no such report present that can explain the present scenario in the field of electrochemical synthesis. So, this encouraged us to write a review on this interesting topic. Result: From this study, we concluded that the electrochemical methods provide a green and proficient methodology for radical intermediate’s age utilizing electrons as traceless reagents, which could avoid the use of harmful oxidants and reductants.

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Electrochemical Synthesis of Fluorinated Orthoesters from 1,3‐Benzodioxoles

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New Redox Strategies in Organic Synthesis by Means of Electrochemistry and Photochemistry

New Redox Strategies in Organic Synthesis by Means of Electrochemistry and Photochemistry

Electrochemical Method: A Green Approach for the Synthesis of Organic Compounds

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