Electrochemical synthesis of a novel purine-based polymer and its use for the simultaneous determination of dopamine, uric acid, xanthine and hypoxanthine

Lan, Dexiang; Zhang, Lei

doi:10.1016/j.jelechem.2015.09.018

Cited by 45 publications

(12 citation statements)

References 42 publications

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“…A possible interpretation of the complex mechanism of 6‐TG electrochemical oxidation at different electrodes in neutral and basic solutions has been previously studied by several authors . Our experimental evidence indicated that 6‐TG may be firstly oxidized with the thiyl radical formation ( E pa 1 ) followed by the rapid chemical step of dimerization of these radicals to form electroactive bis(6‐thioguanyl)disulphide (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Sensor Based on Nanocomposite of Ionic Liquid Modified Graphene Oxide – Chitosan and its Application for Flow Injection Detection of Anticancer Thiopurine Drugs

Shpigun

Andryukhina

2018

Electroanalysis

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Electrochemical activity of carbositall electrodes (CSEs) covered with polymeric films of Chitosan (Chit) containing different types of graphene oxide (GO) dispersed in a room temperature ionic liquid (IL) was comparatively investigated by using cyclic voltammetry of [Fe(CN)6]3−/4− as a model redox probe. It was recognized that the nanocomposite film with in situ electrochemically reduced GO (ERGO) provided an improved electrochemical activity, including increased peak current and electron‐transfer efficiency, compared to the initial GO nanosheets and chemically reduced GO (RGO). The novel electrochemical sensor ERGO‐IL‐Chit/CSE showed enhanced electrochemical response characteristics towards the antimetabolic thiopurines such as 6‐thioguanine, 6‐mercaptopurine and azathioprine which play a significant role in medicinal chemistry and cancer therapy. The diagnostic characteristics of the voltammetric signals for all investigated compounds in neutral aqueous media were established and the nature of the corresponding redox‐reactions was discussed. The developed sensor was incorporated into a flow injection amperometric system for the automatic dissolution testing of thiopurine anticancer drugs with a sampling rate of 60 h−1.

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Section: Resultsmentioning

confidence: 99%

Electrochemical Sensor Based on Nanocomposite of Ionic Liquid Modified Graphene Oxide – Chitosan and its Application for Flow Injection Detection of Anticancer Thiopurine Drugs

Shpigun

Andryukhina

2018

Electroanalysis

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“…A DPV sensor gave a LOD of 70 nM and a linear range from 1 μM to 550 μM for the sensing of UA in PBS solution at pH 3. A film of poly (6-thioguanine) on a glassy carbon electrode (P6-TG/GCE) was electrogenerated by Lan and Zhang for simultaneous detection of DA, UA, xanthine (XA), and hypoxanthine (HXA) [ 152 ]. SEM images showed a rough polymeric film (see Figure 14 ) providing an increased effective surface area of the electrode.…”

Section: Electrochemical Sensors Based On Conducting Polymersmentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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Electrochemical sensors appear as low-cost, rapid, easy to use, and in situ devices for determination of diverse analytes in a liquid solution. In that context, conducting polymers are much-explored sensor building materials because of their semiconductivity, structural versatility, multiple synthetic pathways, and stability in environmental conditions. In this state-of-the-art review, synthetic processes, morphological characterization, and nanostructure formation are analyzed for relevant literature about electrochemical sensors based on conducting polymers for the determination of molecules that (i) have a fundamental role in the human body function regulation, and (ii) are considered as water emergent pollutants. Special focus is put on the different types of micro- and nanostructures generated for the polymer itself or the combination with different materials in a composite, and how the rough morphology of the conducting polymers based electrochemical sensors affect their limit of detection. Polypyrroles, polyanilines, and polythiophenes appear as the most recurrent conducting polymers for the construction of electrochemical sensors. These conducting polymers are usually built starting from bifunctional precursor monomers resulting in linear and branched polymer structures; however, opportunities for sensitivity enhancement in electrochemical sensors have been recently reported by using conjugated microporous polymers synthesized from multifunctional monomers.

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“…For that, electrodes have been modified with Nafion®, [34,35] self-assembled monolayers at gold electrodes, [36,37] polymer-films, [38] surfactants, [39] molecular imprinted polymers, [40] amino acids and DNA. [41] Also, the covalent modification of CNTs at the electrode surface by different functional groups or the noncovalent adsorption of aromatic compounds can improve the selectivity. [42,43] SAM layers can also be advantageous for improved signal stability.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Activity Determination of Catechol‐O‐methyl Transferase by Selective Dopamine Detection

et al. 2019

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For the treatment of Parkinson's disease, as one of the most frequent diseases of the central nervous system, several key enzymes for dopamine metabolism [e. g. catechol‐O‐methyl transferase (COMT)] are drug targets. For an efficient and long‐lasting treatment, the activity of this enzyme should be monitored. In this study, an electrochemical approach using differential pulse voltammetry (DPV) is introduced for the activity determination. The applied electrode material, fluorine‐doped tin oxide (FTO), is characterized by a clear discrimination between substrate and product of COMT, a high stability of the dopamine signal during consecutive measurements, and a linear dependency on the dopamine concentration in the range of the maximum reaction rate of COMT. Despite these advantageous results, dopamine detection in the complete activity assay is influenced by each of the added essential assay components, even though none of the added components reveal a current signal at the FTO electrode itself. After adjusting the potential range and the assay composition, these effects can be circumvented. By following the dopamine concentrations during COMT action, it can be shown that the activity of COMT can be detected by using differential pulse voltammetry (DPV) at an FTO electrode and, by analyzing different COMT amounts, quantification can be demonstrated.

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Electrochemical synthesis of a novel purine-based polymer and its use for the simultaneous determination of dopamine, uric acid, xanthine and hypoxanthine

Cited by 45 publications

References 42 publications

Electrochemical Sensor Based on Nanocomposite of Ionic Liquid Modified Graphene Oxide – Chitosan and its Application for Flow Injection Detection of Anticancer Thiopurine Drugs

Electrochemical Sensor Based on Nanocomposite of Ionic Liquid Modified Graphene Oxide – Chitosan and its Application for Flow Injection Detection of Anticancer Thiopurine Drugs

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

Electrochemical Activity Determination of Catechol‐O‐methyl Transferase by Selective Dopamine Detection

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