Electrochemical synthesis and characterization of poly(thionine)-deep eutectic solvent/carbon nanotube–modified electrodes and application to electrochemical sensing

Dalkıran, Berna; Fernandes, Isabel P.G.; David, Melinda; Brett, Christopher M.A.

doi:10.1007/s00604-020-04588-x

Cited by 26 publications

(7 citation statements)

References 48 publications

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“…For polymer electrosynthesis, parameters such as surface tension, polarity, and viscosity have a strong influence on the structure of the films [ 13 ]. This has been shown for poly(3,4-ethylenedioxythiophene) [ 14 , 15 ], polyaniline [ 16 , 17 , 18 ], 3-aminophenylboronic acid [ 19 ], polypyrrole [ 20 , 21 ], poly(acrylic acid) [ 22 ], poly(ethylene terephthalate) [ 23 ], poly(brilliant cresyl blue) [ 24 ], poly(thionine) [ 25 ], poly(methylene green) [ 26 ], and poly(neutral red) [ 27 ], mainly because of their control of monomer reactivity and mass transport properties.…”

Section: Introductionmentioning

confidence: 92%

Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

Hosu

Bârsan

Săndulescu

et al. 2021

Sensors

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A novel hybrid composite of conductive poly(methylene blue) (PMB) and carbon nanotubes (CNT) was prepared for the detection of 5-aminosalicylic acid (5-ASA). Electrosynthesis of PMB with glassy carbon electrode (GCE) or with carbon nanotube modified GCE was done in ethaline deep eutectic solvent of choline chloride mixed with ethylene glycol and a 10% v/v aqueous solution. Different sensor architectures were evaluated in a broad range of pH values in a Britton-Robinson (BR) buffer using electrochemical techniques, chronoamperometry (CA), and differential pulse voltammetry (DPV), to determine the optimum sensor configuration for 5-ASA sensing. Under optimal conditions, the best analytical performance was obtained with CNT/PMBDES/GCE in 0.04 M BR buffer pH 7.0 in the range 5–100 µM 5-ASA using the DPV method, with an excellent sensitivity of 9.84 μA cm−2 μM−1 (4.9 % RSD, n = 5) and a detection limit (LOD) (3σ/slope) of 7.7 nM, outclassing most similar sensors found in the literature. The sensitivity of the same sensor obtained in CA (1.33 μA cm−2 μM−1) under optimal conditions (pH 7.0, Eapp = +0.40 V) was lower than that obtained by DPV. Simultaneous detection of 5-ASA and its analogue, acetaminophen (APAP), was successfully realized, showing a catalytic effect towards the electro-oxidation of both analytes, lowering their oxidation overpotential, and enhancing the oxidation peak currents and peak-to-peak separation as compared with the unmodified electrode. The proposed method is simple, sensitive, easy to apply, and economical for routine analysis.

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Section: Introductionmentioning

confidence: 92%

Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

Hosu

Bârsan

Săndulescu

et al. 2021

Sensors

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“…Among those nanomaterials, noble metal nanomaterials like AuNPs have many unique characteristics, including good electrical conductivity, high surface-to-volume ratios, and ideal biocompatibility capabilities ( Lin et al, 2020 ; Lopez-Marzo et al, 2018 ). The thionine (THI) molecule has good electrochemical reversibility and stability and the ability to quickly transfer electrons due to the electroactive group contained in the molecular structure, making it a promising electrochemically active molecule ( Yang et al, 2021 ; Dalkiran et al, 2020 ). Herein, encouraged by the superior characteristics of AuNPs and THI, we fabricated a novel electrochemical immunosensor based on the composites of AuNPs and THI capable of extensively improving the sensitivity and speed of the detection and applied it for the first time to the detection of IL-6 in SAH blood samples.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical immunosensor based on gold-thionine for detection of subarachnoid hemorrhage biomarker

Wang

Gao²,

Ni³

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: In clinical work, the realization of an early diagnosis of Subarachnoid hemorrhage (SAH) is primarily based on conventional computed tomography (CT), MR angiography, transcranial Doppler (TCD) ultrasound, and neurological assessments. However, the association between imaging manifestations and clinical findings is insufficiently perfect, particularly in SAH patients in acute phases with a lower amount of blood. The establishment of a direct, rapid and ultra-sensitive detection method based on electrochemical biosensors has emerged as a new competitive challenge in disease biomarkers research.Methods: In this study, a novel free-labeled electrochemical immunosensor for rapidly and sensitively detecting IL-6 in subarachnoid hemorrhage (SAH) blood has been developed using Au nanospheres-thionine composites (AuNPs/THI) as the interface modified on the electrode. Then, we detected IL-6 in blood samples from SAH patients by (enzyme-linked immunosorbent assay) ELISA and electrochemical immunosensor.Results: Under the best conditions, the developed electrochemical immunosensor exhibited a wide linear range from 10−2 ng/mL to 102 ng/mL with a low detection limit of 1.85 pg/mL. Furthermore, when the immunosensor was employed in the analysis of IL-6 in 100% serum, the results obtained by electrochemical immunoassay were consistent with those obtained by ELISA without suffering from other significant biological interference.Discussion: The designed electrochemical immunosensor realizes the detection of IL-6 in actual serum samples with high accuracy and sensitivity, and could potentially become a promising technique for applications in the clinical diagnosis of SAH.

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“…It has been found that Deep Eutectic Solvents or DES, for the initials in English (Deep Eutectic Solvent), exhibit a great potential option for PC electrosynthesis, due to their relative low wide potential windows, chemical stability, ease of preparation, low cost, and biodegradability compared to conventional aqueous and organic solvents (4,5). Furthermore, the synthesis of polymers on DES can lead to formation of films in which DES components are capable of modulating nucleation and growth mechanisms through charge neutralization and changes in oxidation/reduction potentials, promoting cell growth, that is growth in optimizable systems of nanoscale size (6).…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Quantification of Dopamine in Presence of Ascorbic Acid with a Glass Carbon Electrode Modified with Poly5aphen Polymerized from a Deep Eutectic Solvent

et al. 2023

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In this work, the surface of a glassy carbon electrode (GCE) was modified with the polymer of 5-Amino-1-10 phenanthroline (5Aphen), Poly5Aphen, from a deep eutectic solvent (DES). The electrochemical response of the modified electrode (GCE/Poly5Aphen) was established regarding the oxidation of dopamine (DA) in the presence of ascorbic acid (AA) that is one of its major interferents. The results obtained by cyclic voltammetry (CV) showed that it is possible to polymerize 5Aphen on the surface of the GCE when using a DES. On the other hand, the results by CV and differential pulse voltammetry (DPV) showed that, unlike the bare GCE, when using the GCE/Poly5Aphen electrode it is possible to separate the electrochemical signal of the DA and AA as result of their simultaneous oxidation over the modified surface of the electrode.

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Electrochemical synthesis and characterization of poly(thionine)-deep eutectic solvent/carbon nanotube–modified electrodes and application to electrochemical sensing

Cited by 26 publications

References 48 publications

Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

Electrochemical immunosensor based on gold-thionine for detection of subarachnoid hemorrhage biomarker

Electrochemical Quantification of Dopamine in Presence of Ascorbic Acid with a Glass Carbon Electrode Modified with Poly5aphen Polymerized from a Deep Eutectic Solvent

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