Electrochemical study of the complexes of aspartame with Cu(II), Ni(II) and Zn(II) ions in the aqueous medium

Çakır, Semiha; Coşkun, Emine; Bíçer, Ender; Çakir, Osman

doi:10.1016/s0008-6215(03)00111-3

Cited by 16 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained data suggest that one molecule of neotame interacts with the Zn 2+ ion resulting in neotame-Zn 2+ complex. The stoichiometry ratio of the complex was found to be 1:1 (Neotame: Zn 2+ ) and confirmed by the Job’s method as well as with a literature report 5 . The Harvey and Manning equation 30 was used to calculate the conditional formation constant (log K) of neotame-Zn 2+ complex and found to be 4.09.…”

Section: Resultssupporting

confidence: 83%

“…The studies on complexes of metal ions are very important for biological systems which leads to the clarification of clinical results. The structure of neotame is similar to that of aspartame in terms of functional groups, therefore it acts as a ligand due to the presence of carboxyl and amino groups for metal ion chelation of biological importance 5 . In the recent years, due to the novelty of neotame in the food market, studies on metal ions complexation in solution phase is of growing interest 6–16 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling of neotame and fructose thermochemistry: Comparison with mono and divalent metal ions by Computational and experimental approach

Sharma

Kanchi

Bathinapatla

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The metal complexes can demonstrate various interesting biological activities in the human body. However, the role of certain metal ions for specific cell activities is still subject to debate. This study is aimed at comparing the thermochemical properties of neotame (artificial sweetener) and α, β-fructose in gas phase and water medium. The interaction of α and β-fructose, neotame with monovalent and divalent metal ions was studied and comprehended by density functional theory (DFT) using B3LYP functional, 6–311 + G (d, p) and D3 basis set. Metal ion affinities (MIA) values depicted that ionic radius of metal ions played an important role in the interaction of α, β-fructose and neotame. The ∆G parameter was calculated to predict and understand the interaction of metal ions with α and β-fructose, neotame. The results suggested that the presence of hydroxyl groups and oxygen atoms in sugar molecules acted as preferred sites for the binding and interaction of mono and divalent ions. For the first time computational study has been introduced in the present study to review the progress in the application of metal binding with sugar molecules especially with neotame. Moreover, voltammetric behaviour of neotame-Zn2+ was studied using cyclic and differential pulse voltammetry. The obtained results suggest that the peak at −1.13 V is due to the reduction of Zn2+ in 0.1 M phosphate buffer medium at pH 5.5. Whereas, addition of 6-fold higher concentration of neotame to the ZnCl2.2H2O resulted in a new irreversible cathodic peak at −0.83, due to the reduction of neotame-Zn2+ complex. The Fourier transform infrared spectroscopy (FTIR) results indicates that the β-amino group (-NH) and carboxyl carbonyl (-C = O) groups of neotame is participating in the chelation process, which is further supported by DFT studies. The findings of this study identify the efficient chelation factors as major contributors into metal ion affinities, with promising possibilities to determine important biological processes in cell wall and glucose transmembrane transport.

show abstract

Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Modeling of neotame and fructose thermochemistry: Comparison with mono and divalent metal ions by Computational and experimental approach

Sharma

Kanchi

Bathinapatla

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…As expected, black Au precipitates appeared following the addition of DMSO, as shown in Figure S6a (marked with I, Additional file 1 ). To further investigate this assumption, the pH of APM-AuNPs solution was raised to 12.0, which is higher than the p K a values of APM (3.1 and 7.9) [ 32 ]. Notably, the aqueous solution turned light blue (see Figure S6b, marked with I, Additional file 1 ), indicating that the aggregation occurred [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Green synthesis of gold nanoparticles using aspartame and their catalytic activity for p-nitrophenol reduction

Yan

et al. 2015

Nanoscale Res Lett

View full text Add to dashboard Cite

We demonstrated a facile and environmental-friendly approach to form gold nanoparticles through the reduction of HAuCl4 by aspartame. The single-crystalline structure was illustrated by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared (FTIR) results indicated that aspartame played a pivotal role in the reduction and stabilization of the gold crystals. The crystals were stabilized through the successive hydrogen-bonding network constructed between the water and aspartame molecules. Additionally, gold nanoparticles synthesized through aspartame were shown to have good catalytic activity for the reduction of p-nitrophenol to p-aminophenol in the presence of NaBH4.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-015-0910-7) contains supplementary material, which is available to authorized users.

show abstract

“…As expected, black Au precipitates appeared following the addition of DMSO, as shown in Figure S6a (marked with I, Additional file 1). To further investigate this assumption, the pH of APM-AuNPs solution was raised to 12.0, which is higher than the pKa values of APM (3.1 and 7.9) [32]. Notably, the aqueous solution turned light blue (see Figure S6b, marked with I, Additional file 1), indicating that the aggregation occurred [28].…”

Section: Schematic Model Of Apm-aunps Synthesismentioning

confidence: 99%

Green synthesis of gold nanoparticles using aspartame and their catalytic activity for p-nitrophenol reduction

Wu¹,

Yan²,

Qi³

et al. 2016

Nano Online

View full text Add to dashboard Cite

We demonstrated a facile and environmental-friendly approach to form gold nanoparticles through the reduction of HAuCl 4 by aspartame. The single-crystalline structure was illustrated by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared (FTIR) results indicated that aspartame played a pivotal role in the reduction and stabilization of the gold crystals. The crystals were stabilized through the successive hydrogen-bonding network constructed between the water and aspartame molecules. Additionally, gold nanoparticles synthesized through aspartame were shown to have good catalytic activity for the reduction of p-nitrophenol to p-aminophenol in the presence of NaBH 4 .

show abstract

Electrochemical study of the complexes of aspartame with Cu(II), Ni(II) and Zn(II) ions in the aqueous medium

Cited by 16 publications

References 22 publications

Modeling of neotame and fructose thermochemistry: Comparison with mono and divalent metal ions by Computational and experimental approach

Modeling of neotame and fructose thermochemistry: Comparison with mono and divalent metal ions by Computational and experimental approach

Green synthesis of gold nanoparticles using aspartame and their catalytic activity for p-nitrophenol reduction

Green synthesis of gold nanoparticles using aspartame and their catalytic activity for p-nitrophenol reduction

Contact Info

Product

Resources

About