Electrochemical Study and Hydrolysis Kinetic of Imidazo-and Triazolobenzodiazepines

Viré, Jean‐Claude; Gallo, Blanca; Patriarche, Gaston

doi:10.1080/00032718608066507

Cited by 16 publications

(5 citation statements)

References 12 publications

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“…In the case of midazolam, hydrolysis is faster than for triazolam but ils reactivity should be attributed to the présence of a fluorine atom in the ortho position on the aryl ring rather than to the double-bonded carbon atom at C, [27].…”

Section: Resultsmentioning

confidence: 99%

Polarographic behaviour and degradation studies of triazolam

Viré¹,

Patriarche²

1986

Journal of Electroanalytical Chemistry and Interfacial Electroc

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The electrochemical behaviour of triazolam has been determined using polarographic and cycHc voltammetric techniques. It appears that this compound is reduced following a classical process. A study of the hydrolytic reaction which occurs in acidic média shows that the triazole ring and the 5-o-phenyl substituent have a marked influence on the kinetics. Rate constants, half-life times, the order of the reaction and the degree of completion have been determined. The benzophenone structure of the hydrolysis product has been confirmed by '""C NMR. Quantitative analysis has been conducted, showing that triazolam can be determined up to 1x10"^ M using dp polarography.

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Section: Resultsmentioning

confidence: 99%

Polarographic behaviour and degradation studies of triazolam

Viré¹,

Patriarche²

1986

Journal of Electroanalytical Chemistry and Interfacial Electroc

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“…pKa ϭ Ϫ0.24 As the pKa 3 and pKa 2 values are close, the two microforms 3 and 4 have to be considered. The ionization equilibria suggesting them and the corresponding micro-constants are given in Scheme 8.…”

Section: Appendix: Ionization Constantsmentioning

confidence: 99%

Determination of the kinetic constants of the reversible opening of a triazolo-1,4-thienodiazepine in water at different pH values: A striking example of the determination of intimately intricate kinetic and equilibrium constants

Legouin¹,

Burgot²

1999

Int J Chem Kinet

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Apparent kinetic constants of the reversible opening of a triazolo-1,4-thienodiazepine were determined by UV-spectrophotometry and by polarography in water at several pH values assuming as a hypothesis a stationary state for the carbinolamine intermediate. Both the apparent kinetic constants, k f and k r , exhibited a maximum for the values H 0 ϭ Ϫ0.25 and pH ϭ 6.07. A possible determination of the elementary kinetic constants of the several acidobasic species which may be involved in the opening and closing process according to the pH and pKa values was studied and is discussed. The results are consistent with the hypothesis that both the opening of the diazepine cycle and the closing of the opened form proceed through a mechanism suggesting that the protonated form of the carbinolamine function of the intermediate is involved.

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“…The different analytical techniques that have been reported for the determination of this drug in biological fluids and pharmaceutical formulations include high performance liquid chromatography, [5][6][7][8][9][10] high performance thin layer chromatography, 11 liquid chromatography, 12,13 infrared spectroscopy, 14 fluorometry, 15 and electrochemical methods. 16,17 In the literature only few spectrophotometric methods have been reported. Sastry et al 18 have described two spectrophotometic methods for the determination of amiodarone hydrochloride based on its reaction with a known excess of iodine or ammonium molybdate; one can estimate the unreacted iodine or reduced ammonium molybdate with metol-sulfanilic acid or potassium thiocyanate.…”

mentioning

confidence: 99%

Validated Spectrophotometric Methods for the Determination of Amiodarone Hydrochloride in Commercial Dosage Forms Using p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

2004

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Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as n-electron donor with p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π-acceptors to give highly colored complex species which absorb maximally at 535 and 570 nm, respectively. Beer's law is obeyed in the concentration ranges 10.0 -360.0 and 2.0 -65.0 µg ml -1 for methods A and B, respectively. Application of the proposed methods to commercial pharmaceutical tablets are presented.

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Electrochemical Study and Hydrolysis Kinetic of Imidazo-and Triazolobenzodiazepines

Cited by 16 publications

References 12 publications

Polarographic behaviour and degradation studies of triazolam

Polarographic behaviour and degradation studies of triazolam

Determination of the kinetic constants of the reversible opening of a triazolo-1,4-thienodiazepine in water at different pH values: A striking example of the determination of intimately intricate kinetic and equilibrium constants

Validated Spectrophotometric Methods for the Determination of Amiodarone Hydrochloride in Commercial Dosage Forms Using p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

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