Electrochemical Studies on Some Substituted Thiadiazoles

El‐Maghraby, A. A.; Abou‐Elenien, G. M.; Abdel-Reheem, N. A.; Abdel-Tawab, H. R.

doi:10.5012/jkcs.2006.50.4.307

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…This agrees well with that established for similar model compound containing the same -HN-CO-NH-electroactive center. 22 The oxidation of the two amine groups linked to the carbonyl group is suggested to occur in a one-step mechanism 57 involving the removal of one e − and one H + from each of them. 22,57 The di-amine radical is expected to stabilize by dimerization into a six membered ring to give the bis compound.…”

Section: Electrode Reaction Mechanism Of Sora At Bare and The Develop...mentioning

confidence: 99%

“…22 The oxidation of the two amine groups linked to the carbonyl group is suggested to occur in a one-step mechanism 57 involving the removal of one e − and one H + from each of them. 22,57 The di-amine radical is expected to stabilize by dimerization into a six membered ring to give the bis compound. 22 These formed dimeric species were reversibly reduced in a single two electron at lower potential (peak P c /peak P a ) 22 as shown in Scheme 2.…”

Section: Electrode Reaction Mechanism Of Sora At Bare and The Develop...mentioning

confidence: 99%

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Nano Determination of KinaseInhibitor Sorafenib Drug in Pharmaceutical Formulation and Human Blood at a Modified Carbon Paste Electrode

Ghoneim

El‐Desoky

Ahmed

et al. 2016

J. Electrochem. Soc.

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Sorafenib (SORA) has clinical activity against several tumor types. Carbon paste electrode modified with natural sodium montmorillonite clay (Na-MMT/CPE) was used as a sensor for sensitive and selective determination of SORA drug using square-wave adsorptive anodic stripping voltammetry (SW-AdASV). Unmodified CPE as well as the modified one were characterized using scan electron microscopy (SEM), N2 sorption isotherms (BET) and electrochemical impedance spectra (EIS). In spite of the very low conductivity of Na-MMT, a shift in the peak potential to less positive and about two times enhancement in the peak current were observed at 5% (w/w) Na-MMT/CPE compared to that at bare CPE, reflecting electrocatalytic activity of Na-MMT toward oxidation of SORA. This may be attributed to strong adsorptive property of Na-MMT due to its high surface area or specific bonding reactions of SORA with the functional groups at the edges of clay sheets. The method was employed successfully to determine SORA in its pharmaceutical formulation (Nexavar tablets). Detection limit of 1.5 × 10−10 M was also achieved in human serum. The described method is reliable, simple and sensitive enough for assay of SORA in real plasma samples, pharmacokinetic studies, quality control and assurance of the drug in industry and in clinical laboratories.

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Section: Electrode Reaction Mechanism Of Sora At Bare and The Develop...mentioning

confidence: 99%

Section: Electrode Reaction Mechanism Of Sora At Bare and The Develop...mentioning

confidence: 99%

Nano Determination of KinaseInhibitor Sorafenib Drug in Pharmaceutical Formulation and Human Blood at a Modified Carbon Paste Electrode

Ghoneim

El‐Desoky

Ahmed

et al. 2016

J. Electrochem. Soc.

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“…The electrochemistry of heterocyclic compounds with nitrogen heteroatom has been extensively studied [1][2][3][4][5][6][7][8][9]. In spite of great importance and wide uses of the heterocyclic aromatic compounds with oxygen or sulphur atoms, it is rare to find an attempt to study their electrochemical redox characteristics.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Study of Some Substituted Chromene Derivatives in Nonaqueous Media at Pt, Au and Glassy Carbon Electrodes

El‐Maghraby¹

2009

TOELECJ

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Abstract:The redox characteristics of some substituted chromene derivatives has been investigated in different nonaqueous solvents such as, 1,2-dichloroethane (DCE), dichloromethane (DCM) and acetonitrile (AN) using 0.1mol dm -3 tetrabutylammonium perchlorate (TBAP) as a supporting electrolyte at platinum, gold and glassy carbon electrodes, using cyclic voltammetry. Through controlled potential electrolysis (CPE), the product of oxidation and reduction can be separated and identified. The product of oxidation was found to be the corresponding bis-compound. On the other hand, the reduction occurs in a single two electron process to give the dianion, which abstracts protons to saturate the (-C=O) bond. The effect of substituents on the redox mode of an electroactive site has also been studied.

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