Electrochemical studies and potential anticancer activity in ferrocene derivatives

Realista, Sara; Quintal, Susana; Martinho, Paulo N.; Melato, A.I.; Gil, Adrià; Esteves, Teresa; Carvalho, Maria Graça; Ferreira, Liliana P.; Vaz, Pedro D.; Calhorda, Maria José

doi:10.1080/00958972.2016.1257125

Cited by 27 publications

(19 citation statements)

References 80 publications

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“…Based on the best knowledge, ferrocene, xanthone, azine, and triazole bearing compounds have the good anticancer activity, individually. Now, it has been possible that these frameworks were together in the polymer backbone and show the synergic effect.…”

Section: Resultsmentioning

confidence: 99%

“…In particular, considerable attention has been paid to their antitumor, anti‐inflammatory, antimicrobial, cytotoxic, and DNA‐cleaving characteristics . The stability, significant electroactivity, and high spectroscopic activity of ferrocene‐based organometallics make them potential candidate for many biological applications …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] The stability, significant electroactivity, and high spectroscopic activity of ferrocene-based organometallics make them potential candidate for many biological applications. [7][8][9][10] On the other hand, organometallic polymers have attracted much attention in the recent years due to their unique properties and huge applications in the areas of catalysts, magnetoceramics, electrode modifiers, nonlinear optical devices, electrochemical sensors, etc. [11][12][13][14][15][16][17] Because of unique properties of ferrocene (Fc)-containing polymers such as ready availability, high stability, unique structure, and redox activity of Fc moiety, these polymers are drawing increasing interests in polymer science and pharmaceuticals.…”

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confidence: 99%

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Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Lakouraj

Hasantabar

Tashakkorian

et al. 2018

Polymers for Advanced Techs

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Poly(azine ferrocene‐triazole‐xanthone amide) (PAFTXA) was successfully synthesized from azine ferrocene bisacetylene (AFcB) and 2,7‐(N‐2‐azidoacetamide) xanthone (NAzX) by using click chemistry protocol. In this paper, innovative AFcB moiety incorporated in this procedure as a monomer. This monomer was prepared in three steps from ferrocene scaffold, and the synthetic processes were discussed in details. Characterization of the synthesized novel intermediate materials, monomer, and the resulting polymer was performed by nuclear magnetic resonance, Fourier transform infrared, thermal gravimetric analysis, differential scanning calorimetry, and ultraviolet‐visible spectrophotometer. In addition, the in vitro antibacterial activity of the polymer was appraised against Gram‐positive and Gram‐negative bacteria by using minimum inhibitory concentration method. Moreover; antitumoral effects of synthesized polymer were evaluated on Hela, MCF‐7, and Saos cancer cell lines and compared with normal fibroblast cell line by means of 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. Promising antiproliferative effects were detected on both epitheloid and mesenchymal cancer cell lines depending on PAFTXA concentration and time. Survey on its characteristic features revealed the proficiencies of our prepared biomaterial such as its high thermal stability as well as valuable antitumoral and antibacterial capabilities that make it an appreciable candidate for further bioapplications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Lakouraj

Hasantabar

Tashakkorian

et al. 2018

Polymers for Advanced Techs

View full text Add to dashboard Cite

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“…The pharmacochemistry of ferrocene derivatives has attracted the attention of many scientists, and their study has been encouraged by potential biological applications [25][26][27]. Many ferrocene derivatives that have been studied in the last decade show important biological activities, such as cytotoxic [28][29][30], antimicrobial [31,32] and antitumor [33][34][35][36][37][38] activities.…”

Section: Introductionmentioning

confidence: 99%

BSA-binding studies of 2- and 4-ferrocenylbenzonitrile: voltammetric, spectroscopic and molecular docking investigations

Benamara

Lanez

2020

J. Electrochem. Sci. Eng.

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The binding affinity of 2-ferrocenylbenzonitrile (2FBN) and 4-ferrocenylbenzonitrile (4FBN) with bovine serum albumin (BSA) has been investigated by cyclic voltammetry, absorption spectroscopy and molecular modelling techniques. The results indicated that both of the two derivatives could bind to BSA and cause conformational changes with the order 2FBN > 4FBN. The voltammetric behavior of 2FBN and 4FBN before and after the addition of the BSA suggests that the redox process is kinetically controlled by the diffusion step, and demonstrated that the diffusion coefficients of the 2FBN-BSA and 4-FBN-BSA adducts are lower than that of the free compounds. Furthermore, molecular docking suggested that the binding mode of the two compounds to BSA is of hydrophobic and hydrogen bond interactions, moreover the ligand 2FBN additionally show a π-cation interaction.

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“…3 Zahvaljujući lakoj funkcionalizaciji ugljikovih atoma na jednom ili oba ciklopentadienilna prstena, sintetiziran je velik broj ferocenskih konjugata koji sadrže organske ili anorganske fragmente pokrivajući tako različita područja znanstvenog istraživanja, od katalize, dizajna optičkih materijala i biosenzora do novih biološki aktivnih spojeva. 3,4 Mnogi ferocenski konjugati pokazuju biološku aktivnost poput antitumorske, antibakterijske, antiparazitske i antifungalne. 5 Osim što se uvodi u strukturu već poznatih lijekova, ferocen se konjugira i s nukleobazama kao biološki i farmakološki značajnim molekulama s ciljem sinteze biokonjugata koji će pokazati poboljšanu biološku aktivnost i poslužiti u medicinskoj i farmaceutskoj kemiji za razvoj novih terapeutskih agenasa.…”

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Redoks-svojstva ferocenom supstituiranih nukleobaza

Toma

Vrček

2020

Kem. ind. (Online)

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Pripravljena je serija ferocenom supstituiranih purinskih nukleobaza 1-10 te su izmjereni njihovi redoks-potencijali metodom cikličke voltametrije. Svi ispitani spojevi pokazali su reverzibilnu jednoelektronsku oksidaciju u rasponu potencijala od 330 do 470 mV. Također je uočena razlika redoks-potencijala od 100 mV između N7 i N9 regioizomera ispitivanih nukleobaza. Ispitana je i acelularna aktivnost stvaranja reaktivnih kisikovih vrsta (ROS) kolorimetrijskom metodom s DCFH<sub>2</sub>-DA te je utvrđeno da konjugati generiraju ROS, dok su ferocen i nukleobaze neaktivni. Različiti supstituenti na purinskom prstenu utječu na stvaranje ROS-a, što omogućuje dizajn biološki aktivnih konjugata ferocena i prikladnih nukleobaza.

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Electrochemical studies and potential anticancer activity in ferrocene derivatives

Cited by 27 publications

References 80 publications

Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

BSA-binding studies of 2- and 4-ferrocenylbenzonitrile: voltammetric, spectroscopic and molecular docking investigations

Redoks-svojstva ferocenom supstituiranih nukleobaza

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