Electrochemical single-molecule conductivity of duplex and quadruplex DNA

Abstract

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Electronic Level Structure of Novel Guanine Octuplex DNA Single Molecules

“…Building upon our prior knowledge regarding G4-DNA’s high conductivity along and across the molecule − and the current understanding of the electronic structure of G4-DNA and G8-DNA arising from this study, it is highly plausible that G8-DNA is expected to be a highly conductive nanowire, surpassing G4-DNA in this arena. This attribute, along with G8-DNA’s high stability and resistance to mechanical deformation, makes G8-DNA a compelling new molecule and a great candidate for molecular nanoelectronics.…”

“…With the goal of achieving enhanced mechanical stability and robustness, along with additional charge transport routes along the molecule, strand annexation by different methods has been pursued, yielding triplex ,− and quadruplex ,,, G-based nanostructures. Indeed, guanine quadruplex (G4-) DNA structures, composed of stacks of guanine (G-) quartets, were found to be thermodynamically stable, ,, mechanically robust, , resistant to DNA-digesting enzymes, resistant to standard denaturation conditions, ,− and highly conductive when compared to duplex DNA. − …”

Additive transport in DNA molecular circuits

“…Scanning tunneling microscopy break junction (STM-BJ) technique has been a method of choice for determining single molecule conductance values of dsDNA in different environments. 6,9,11–22 A selection of proper experimental conditions enabled STM-BJ studies of DNA duplexes in one of the three most common dsDNA forms: A, B or Z. 9 The conductance was studied as a function of the varied molecular length and composition ( i.e.…”