Electrochemical sensors for simultaneous detection of dopamine and uric acid based on a composite of electrochemically reduced graphene oxide and PEDOT:PSS-modified glassy carbon electrode

Ta'alia, Shafa Aini Hasnawati; Rohaeti, Eti; Putra, Budi Riza; Wahyuni, Wulan Tri

doi:10.1016/j.rechem.2023.101024

Cited by 7 publications

(4 citation statements)

References 64 publications

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“…Although sensitive and selective detection of DA in the presence of the interfering species is possible using a screen-printed electrode (SPE) or glassy carbon (GC) electrode, detecting dopamine in attoliter droplets using an SPE or GC electrode is challenging due to the large capacitive current, which is proportional to the electrode area [48][49][50][51]. With UME having a micron-scale electroactive area, the dopamine in the attoliter vesicle can be detected.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Characterization of Neurotransmitters in a Single Submicron Droplet

Park,

Park

2024

Biosensors

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Single-entity electrochemistry, which employs electrolysis during the collision of single particles on ultramicroelectrodes, has witnessed significant advancements in recent years, enabling the observation and characterization of individual particles. Information on a single aqueous droplet (e.g., size) can also be studied based on the redox species contained therein. Dopamine, a redox-active neurotransmitter, is usually present in intracellular vesicles. Similarly, in the current study, the electrochemical properties of neurotransmitters in submicron droplets were investigated. Because dopamine oxidation is accompanied by proton transfer, unique electrochemical properties of dopamine were observed in the droplet. We also investigated the electrochemical properties of the adsorbed droplets containing DA and the detection of oxidized dopamine by the recollision phenomenon.

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Section: Resultsmentioning

confidence: 99%

Electrochemical Characterization of Neurotransmitters in a Single Submicron Droplet

Park,

Park

2024

Biosensors

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“…In contrast, electrochemical methods based on a disposable screen-printed carbon electrode (SPCE) offer an excellent alternative option for onsite pesticide detection owing to their rapid, low-cost, simple operation, versatility, and high sensitivity. − Meanwhile, the employment of different shapes of gold nanoparticles via nanospheres, − nanorods, − nanocubes, − nanostars, − nanocages, − nanotriangles, − nanohexagon, − and nanobipyramids − has been widely explored to enhance its sensitivity for the purpose of sensing applications. Among these various shapes of gold nanoparticles, gold nanorods (AuNRs) have attracted considerable attention due to their anisotropic structures and high surface area that could facilitate faster electron transfer capability on the electrode surface .…”

Section: Introductionmentioning

confidence: 99%

Effect of Aspect Ratio of a Gold-Nanorod-Modified Screen-Printed Carbon Electrode for Carbaryl Detection in Three Different Samples of Vegetables

Wahyuni,

Putra,

Rahman

et al. 2023

ACS Omega

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In this study, three different sizes of gold nanorods (AuNRs) were synthesized using the seed-growth method by adding various volumes of AgNO 3 as 400, 600, and 800 μL into the growth solution of gold nanoparticles. Three different sizes of AuNRs were then characterized using UV−vis spectroscopy, highresolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED) patterns, and atomic force microscopy (AFM) to investigate the surface morphology, topography, and aspect ratios of each synthesized AuNR. The aspect ratios from the histogram of size distributions of three AuNRs as 2.21, 2.53, and 2.85 can be calculated corresponding to the addition of AgNO 3 volumes of 400, 600, and 800 μL. Moreover, each AuNR in three different aspect ratios was drop-cast onto the surface of a commercial screen-printed carbon electrode (SPCE) to obtain three different SPCE-modified AuNRs (SPCE-A400, SPCE-A600, and SPCE-A800, respectively). All SPCE-modified AuNRs were then evaluated for their electrochemical behavior using cyclic voltammetry and electrochemical impedance spectroscopy (EIS) techniques and the highest electrochemical performance was shown as the order of magnitude of SPCE-A400 > SPCE-A600/SPCE-A800. The reason for the highest electrocatalytic activity of SPCE-A400 might be due to the smallest particle size and uniform distribution of AuNRs ∼ 2.2, which enhanced the charge transfer, thus providing the highest electroactive surface area (0.6685 cm 2 ) compared to other electrodes. These results also confirm that the sensing mechanism for all SPCE-modified AuNRs is controlled by diffusion phenomena. In addition, the optimum pH was obtained as 4 for carbaryl detection for all SPCE-modified AuNRs with the highest current shown by SPCE-A400. Furthermore, SPCE-A400 has the highest fundamental parameters (surface coverage, catalytic rate constant, electron transfer rate constant, and adsorption capacity) for carbaryl detection, which were investigated using cyclic voltammetry and chronoamperometric techniques. The electroanalytical performances of all SPCE-modified AuNRs for carbaryl detection were also investigated with SPCE-A400 displaying the best performance among other electrodes in terms of its linearity (0.2−100 μM), limit of detection (LOD) ∼ 0.07 μM, and limit of quantification (LOQ) ∼ 0.2 μM. All SPCE-modified AuNRs were also subsequently evaluated for their stability, reproducibility, and selectivity in the presence of interfering species such as NaNO 2 , NH 4 NO 3 , Zn(CH 3 CO 2 ) 2 , FeSO 4 , diazinon, and glucose and show reliable results as depicted from %RSD values less than 3%. At last, all SPCE-modified AuNRs have been employed for carbaryl detection using a standard addition technique in three different samples of vegetables (cabbage, cucumber, and Chinese cabbage) with its results (%recovery ≈ 100%) within the acceptable analytical range. In conclusion, this work demonstrates the great potential of a disposable device based on an AuNR-modified SPCE for rapid detection and high ...

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“…19 Various sensing platforms have been developed using carbon-based materials for several analytes through voltammetry techniques. 20 Carbon-based materials including carbon nanotubes, [21][22][23][24][25] graphene, 2,26 graphene oxide, 27 and ERGO 18,28,29 play a key role in modifying electrodes for many applications. Among these, the ERGO has been employed as an electrode modifier due to its distinctive properties, such as high conductivity and electrocatalytic activity.…”

mentioning

confidence: 99%

“…These qualities facilitate heterogeneous electron transport on the electrode surface, rendering it a valuable component in electrochemical devices. 29 Considering these factors, an electrode modification procedure was conducted utilizing ERGO and L-Lys.…”

mentioning

confidence: 99%

Development of a Cu@ERGO-p(L-Lys) Modified GCE Electrochemical Sensor for the Simultaneous Detection of Ascorbic Acid, Dopamine, and Uric Acid

Atış,

Turan,

Aydoğdu Tığ

2024

J. Electrochem. Soc.

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In this work, a sensitive sensing platform was developed using a glassy carbon electrode (GCE) to simultaneously determine AA, DA, and UA. Cu nanostructures, the poly-L-Lysine (p(L-Lys)), and the electrochemically reduced graphene oxide (ERGO) modified GCE (GCE/Cu@ERGO-p(L-Lys)) was developed via the electrodeposition of Cu and electropolymerization of the ERGO-p(L-Lys). Simultaneous detection makes analysis more efficient and cost-effective by reducing the need for multiple sensors. The GCE/Cu@ERGO-p(L-Lys) was characterized by electrochemical impedance spectroscopy, cyclic voltammetry, and scanning electron microscopy. The limit of detection values for AA, DA, and UA analytes were 0.16, 0.033, and 0.021 μM, respectively, while the linear ranges were 0.53–50.0, 0.11–100.0, and 0.070–0.75 μM. The proposed sensor was found to be applicable for the determination of target analytes in fetal bovine serum samples. The proposed GCE/Cu@ERGO-p(L-Lys) hybrid composite modified electrode is a promising material for simultaneous determination in biological fluids with excellent analytical performance and anti-interference effect.

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Electrochemical sensors for simultaneous detection of dopamine and uric acid based on a composite of electrochemically reduced graphene oxide and PEDOT:PSS-modified glassy carbon electrode

Cited by 7 publications

References 64 publications

Electrochemical Characterization of Neurotransmitters in a Single Submicron Droplet

Electrochemical Characterization of Neurotransmitters in a Single Submicron Droplet

Effect of Aspect Ratio of a Gold-Nanorod-Modified Screen-Printed Carbon Electrode for Carbaryl Detection in Three Different Samples of Vegetables

Development of a Cu@ERGO-p(L-Lys) Modified GCE Electrochemical Sensor for the Simultaneous Detection of Ascorbic Acid, Dopamine, and Uric Acid

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