Electrochemical sensors based on multi-walled nanotubes for investigating the damage and action of 6-mercaptopurine on double-stranded DNA

Abstract

Clear damage to dsDNA caused by 6-MP was observed. The damage to adenine was more severe than to guanine.

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

“…[125] Several modified electrodes have been employed to study the interaction of 6-mercaptopurine (purine analog) with dsDNA; particularly: carbositall electrode modified by AuNPs, chitosan (CHIT), GO and IL (by CV), [153] PGE modified with p-Py and functionalized MWCNTs (by DPV), [145] and GCE modified with MWCNTs and CHIT (by DPV). [154] The results confirmed that 6-mercaptopurine binds to the dsDNA causing its serious damage (the damage to A was more severe than to G), and the interaction process mainly occurs through the intercalation mode, rather than the electrostatic interactions.…”

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

“…It is remarkable that fluorescent nanosensors were developed for this purpose with an acceptable detection limit (0.198 nM). 188–190…”

“…It is remarkable that uorescent nanosensors were developed for this purpose with an acceptable detection limit (0.198 nM). [188][189][190] Many hurdles, including reliability, repeatability, quantitative detection ndings, and biosafety, must be overcome to expedite the translation of nanotechnology as a diagnostic tool into clinical applications. Nonspecic nanoparticle probe binding, aggregation, and unsuitable detection circumstances are only a few issues that might impact nanoparticle-based detection results.…”