Electrochemical sensor for transgenic maize MON810 sequence with electrostatic adsorption DNA on electrochemical reduced graphene modified electrode

Sun, Wei; Lu, Yongxi; Wu, Yajun; Zhang, Yuanyuan; Wang, Ping; Chen, Ying; Li, Guangjiu

doi:10.1016/j.snb.2014.05.072

Cited by 32 publications

(7 citation statements)

References 32 publications

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“…The subsequent detection of complementary analysts can be achieved by using the same graphene transistor devices. [22,96,129] As suggested by Geim and co-workers, [108] weak van der Waals-like interaction between layers could be exploited to sandwich (a process called 'encapsulation') graphene with other 2D layers of, e.g. MoS 2 , mica, or hexagonal boron nitride (h-BN).…”

Section: Non-covalent Functionalizationsmentioning

confidence: 99%

Sensing at the Surface of Graphene Field‐Effect Transistors

et al. 2016

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Abstract. 10Recent research trends now offer new opportunities for developing the next generations of label-free biochemical sensors using graphene and other two-dimensional materials. While the physics of graphene transistors operated in electrolyte is well grounded, important chemical challenges still remain to be addressed, namely the impact of the chemical functionalizations of graphene on the key electrical parameters and the sensing performances. In fact, graphene -at least ideal graphene -is highly chemically inert. The 15 functionalizations and chemical alterations of the graphene surface -both covalently and non-covalently -are crucial steps that define the sensitivity of graphene. The presence, reactivity, adsorption of gas and ions, proteins, DNA, cells and tissues on graphene have been successfully monitored with graphene. This review aims to unify most of the work done so far on biochemical sensing at the surface of a (chemically functionalized) graphene field-effect transistor and the challenges that lie ahead. We are convinced that graphene biochemical sensors 20 hold great promises to meet the ever-increasing demand for sensitivity, especially looking at the recent progresses suggesting that the obstacle of Debye screening can be overcome.2

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Section: Non-covalent Functionalizationsmentioning

confidence: 99%

Sensing at the Surface of Graphene Field‐Effect Transistors

et al. 2016

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“…Hamsawahini et al [31] reported that ERGO-modified electrodes exhibited a good sensitivity of Pb (Ⅱ) ions. Sun et al [32] fabricated an electrochemical DNA biosensor for the detection of the ssDNA sequence with an ERGO electrode. ERGO electrodes also exhibited significantly enhanced catalytic activity toward the oxygen reduction reaction (ORR) in an alkaline medium compared with the initial GO electrode [29].…”

Section: Introductionmentioning

confidence: 99%

Effect of morphology and defect density on electron transfer of electrochemically reduced graphene oxide

Zhang

Wang

2016

Applied Surface Science

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Electrochemically reduced graphene oxide (ERGO) is widely used to construct electrochemical sensors. Understanding the electron transfer behavior of ERGO is essential for its electrode material applications. In this paper, different morphologies of ERGO were prepared via two different methods. Compared to ERGO/GCEs prepared by electrochemical reduction of pre-deposited GO, more exposed edge planes of ERGO are observed on the surface of ERGO-GCE that was constructed by electrophoretic deposition of GO. The defect densities of ERGO were controlled by tuning the mass or concentration of GO. The electron transfer kinetics (k 0 ) of GCE with different ERGOs was comparatively investigated. Owing to increased surface areas and decreased defect density, the k 0 values of ERGO/GCE initially increase and then decrease with incrementing of GO mass. When the morphology and surface real areas of ERGO-GCE are the same, an increased defect density induces an accelerated electron transfer rate. k 0 valuesof ERGO-GCEs are about 1 order of magnitude higher than those of ERGO/GCEs due to the difference in the amount of edge planes. This work demonstrates that both defect densities and edge planes of ERGO play crucial roles in electron transfer kinetics.

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“…The DNA sensor showed high sensitivity and specificity for the detection of the target DNA, with one nuclear base mismatch recognition, due to the utilization of the probe PNA and the ability of ErGO to increase the electron transfer reaction rate. In the same way, it has been shown that the DNA sequence related to transgenic maize (MON810) can be sensed on an ErGO-functionalized carbon ionic liquid electrode on which the probe DNA was immobilized . This illustrates the applicability of these types of electrodes.…”

Section: Overview Of Carbon-based Voltammetric Biosensorsmentioning

confidence: 79%

Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules

et al. 2015

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The study of electrochemical behavior of bioactive molecules has become one of the most rapidly developing scientific fields. Biotechnology and biomedical engineering fields have a vested interest in constructing more precise and accurate voltammetric/amperometric biosensors. One rapidly growing area of biosensor design involves incorporation of carbon-based nanomaterials in working electrodes, such as one-dimensional carbon nanotubes, two-dimensional graphene, and graphene oxide. In this review article, we give a brief overview describing the voltammetric techniques and how these techniques are applied in biosensing, as well as the details surrounding important biosensing concepts of sensitivity and limits of detection. Building on these important concepts, we show how the sensitivity and limit of detection can be tuned by including carbon-based nanomaterials in the fabrication of biosensors. The sensing of biomolecules including glucose, dopamine, proteins, enzymes, uric acid, DNA, RNA, and H2O2 traditionally employs enzymes in detection; however, these enzymes denature easily, and as such, enzymeless methods are highly desired. Here we draw an important distinction between enzymeless and enzyme-containing carbon-nanomaterial-based biosensors. The review ends with an outlook of future concepts that can be employed in biosensor fabrication, as well as limitations of already proposed materials and how such sensing can be enhanced. As such, this review can act as a roadmap to guide researchers toward concepts that can be employed in the design of next generation biosensors, while also highlighting the current advancements in the field.

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Electrochemical sensor for transgenic maize MON810 sequence with electrostatic adsorption DNA on electrochemical reduced graphene modified electrode

Cited by 32 publications

References 32 publications

Sensing at the Surface of Graphene Field‐Effect Transistors

Sensing at the Surface of Graphene Field‐Effect Transistors

Effect of morphology and defect density on electron transfer of electrochemically reduced graphene oxide

Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules

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