Electrochemical sensor for the simultaneous determination of caffeine and aspirin in human urine samples

Goyal, Rajendra N.; Bishnoi, Sunita; Agrawal, Bharati

doi:10.1016/j.jelechem.2011.03.008

Cited by 85 publications

(35 citation statements)

References 37 publications

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“…The separation methods such as capillary electrophoresis (Zhao, Lunte, 1997), thinlayer chromatography (Sullivan, Sherma, 2005), gas chromatography (Jafari et al, 2011) and liquid chromatography (Tzanavaras, Themelis, 2007) were used for the analysis of mixtures containing caffeine and other drugs or metabolites. However, these techniques are mostly very expensive and long time is required for some procedures as derivatization, extraction and purifi cation (Goyal et al, 2011) therefore, the development of reliable, low-cost, rapid, simple and accurate method for caffeine determination in various foodstuffs, pharmaceutical formulations and biological fl uids is needed. This opens the opportunities for the electrochemical methods employment, however only a few papers dealing with an electroanalysis of caffeine on more common electrode materials had appeared.…”

Section: Introductionmentioning

confidence: 99%

Utilization of electrochemical methods in determination of trace elements in beverages

Svítková¹,

Machková²,

Šatkovská³

et al. 2012

Acta Chimica Slovaca

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Electrochemical methods have many inherent advantages such as simplicity, low cost and amenability to miniaturization. A new, sensitive and selective electrochemical method for the caffeine determination using boron doped diamond electrode was developed. It was found by cyclic voltammetry that caffeine provided highly reproducible and well-defi ned irreversible oxidation peak, at very positive potential of +1.55 V vs. Ag/AgCl electrode. The effect of pH and scan rate on the voltammetric response of caffeine oxidation were studied to select the optimum experimental conditions. Linear response of peak current on the concentration in the range from 4 × 10 -7 to 2.5 × 10 -5 mol L -1, good repeatability (RSD of 2.1 %) and the detection limit of 1.5 × 10 -7 mol L -1 without any chemical modifi cations and electrochemical surface pretreatment were observed by differential pulse voltammetry in 0.4 mol L -1 perchloric acid. The effect of possible interfering compounds appeared to be negligible which evidently proved very good selectivity. The proposed method was successfully applied for the caffeine determination in commercially available beverage samples, with results in a close statistical agreement to these declared by manufacturer.

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Section: Introductionmentioning

confidence: 99%

Utilization of electrochemical methods in determination of trace elements in beverages

Svítková¹,

Machková²,

Šatkovská³

et al. 2012

Acta Chimica Slovaca

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“…However, CA E 1/2= 1.3±0.05 V (Fig. A) is similar to that reported in CV at large GC electrodes , and the slope of the

log \frac{i_{l} - i}{i}

vs . E plots obtained from the CV curves is 96±6 mV (1.2 V intercept).…”

Section: Resultsmentioning

confidence: 75%

High Sensitivity and Fast Oxidation of Caffeine in Coffee and Theophylline at Nanostructured Electrodes

et al. 2016

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1Introduction dation potential was higher,i na greementw ith TP structure. Formalp otentials in aqueous solutions that have been previouslyu navailable from electrochemistry of CA and TP were thus obtained. In the determinations of CA and TP,s ensitivity and linear dynamic range (LDR)i n FSV were 1.84 mA cm À2 mM À1 and 0.20-22.0 mmol L À1 and 1.46 mA cm À2 mM À1 and 0.50-30.0 mmol L À1 ,r espectively. FSV determination of CA in coffee sample is demonstrated and the results are in agreement with the results obtained by HPLC-UV.

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“…The obtained irreversible oxidation of these compounds over cathodically pre‐treated BDDE in acid media has already been observed using DPV and MPA detection . The oxidation mechanisms on carbon electrodes proposed in literature involve a transfer of 2‐electron and 2‐proton for PA , 4‐electron and 4‐proton for CA , 1‐electron and 1‐proton for SA and 2‐electron and 1‐proton for ASA .…”

Section: Resultsmentioning

confidence: 99%

Fast and Selective Simultaneous Determination of Acetaminophen, Aspirin and Caffeine in Pharmaceutical Products by Batch Injection Analysis with Multiple Pulse Amperometric Detection

et al. 2017

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In this work is presented a method for simultaneous determination of paracetamol (PA), acetylsalicylic acid (ASA) and caffeine (CA) in pharmaceutical tablets, using a bare boron‐doped diamond working electrode (BDDE) coupled to batch injection analysis system with multiple pulse amperometric detection (BIA‐MPA). The optimized sequence of fast potential pulses were applied on BDDE for acquisition of independent amperograms: +1.0 V for PA oxidation, +1.3 V for oxidation of PA and salicylic acid (SA) generated from a previous alkaline hydrolysis of ASA and +1.6 V in which the three analytes are oxidized (PA, SA and CA). Selective determination of PA is performed using the currents obtained at +1.0 V, while SA and CA signals are indirectly obtained using simple subtraction operations between peak currents from each amperogram and correction factors (CF's). The limitations of such approach on the precision and accuracy as function of BIA‐MPA conditions are discussed. Simultaneous determination of the target drugs in pharmaceutical tablets was performed by BIA‐MPA and the results compared to a HPLC‐DAD method. Under optimized conditions, the proposed method exhibits fast responses (180 injections per hour for the simultaneous determination of the three analytes) and suitable precision (RSDPA: 0.78 %; RSDSA: 1.09 %; RSDCA: 2.73 %). BIA‐MPA method is simple, portable and presents relative low‐cost.

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Electrochemical sensor for the simultaneous determination of caffeine and aspirin in human urine samples

Cited by 85 publications

References 37 publications

Utilization of electrochemical methods in determination of trace elements in beverages

Utilization of electrochemical methods in determination of trace elements in beverages

High Sensitivity and Fast Oxidation of Caffeine in Coffee and Theophylline at Nanostructured Electrodes

Fast and Selective Simultaneous Determination of Acetaminophen, Aspirin and Caffeine in Pharmaceutical Products by Batch Injection Analysis with Multiple Pulse Amperometric Detection

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