Electrochemical Sensor for the Determination of Anticancer Drug 5- Fluorouracil at Glucose Modified Electrode

Abstract

In the present work, the complex oxidation mechanism of glucose at the surface of carbon paste electrode was utilized for the electro deposition of glucose. As compared to the bare electrode there was increase in the peak current, which would enhance the sensitivity and selectivity of the electrode. The electro-catalytic activity of the novel electrode was investigated for the oxidation of anticancer drug 5 -fluorouracil. The observed results indicated the applicability of electrode for electrochemical investigation of 5 -fluorouracil with limit of detection and limit of quantification 5.17 nm and 17.2 nM.Investigation for influence of scan rate was used to underatand the electrode process of 5 -fluorouracil. It was observed that it undegoes diffusion controlled process with transfer of two protons and two electrons respectively. In addition, a differential pulse voltammetric technique was developed for the determination of 5 -fluorouracil. The developed method was used for determination of 5 -fluorouracil in pharmaceutical dosage and urine samples. Good recovery from biological sample such as urine indicates the applicability of the proposed method for clinical trials.[a] S.

Direct and Fast Electrochemical Determination of Catechin in Tea Extracts using SWCNT‐Subphthalocyanine Hybrid Material

“…The αn value was calculated from the slope of E p versus log υ (0.0506) to be 1.12. According to Bard and Faulkner, α can be calculated from the following equation: …”

Electrochemical Sensing of Paracetamol Using Electropolymerised and Sodium Lauryl Sulfate Modified Carbon Nanotube Paste Electrode

“…Thus, electrochemical techniques such as voltammetric approach have triggered certain attentiveness for its exploration of redox behaviour of several molecules on appropriate electrode . Hence, cyclic voltammetry (CV) has engaged generous interest as a technique that is proficient, simple and fit for detection of an analyte …”

Determination of Riboflavin at Carbon Nanotube Paste Electrodes Modified with an Anionic Surfactant

“…Which were found to be extremely sensitive to acids and basis media. The drive of these modifiers is due to the reducing over potential for the reduction/oxidation of analytes in contrast with the unmodified electrode . The Objective of the current study is that carbon nanotube paste electrode modified with SLS for voltammetric determination of the RF with wavering parameters like scan rate, pH, and concentration in 0.2 M PBS (pH 7.0).…”

“…The drive of these modifiers is due to the reducing over potential for the reduction/oxidation of analytes in contrast with the unmodified electrode. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The Objective of the current study is that carbon nanotube paste electrode modified with SLS for voltammetric determination of the RF with wavering parameters like scan rate, pH, and concentration in 0.2 M PBS (pH 7.0). To best of our information, there was no voltammetric sensor based on SLSMCNTPE for the determination of RF.…”