Electrochemical sensor for rutin detection based on N-doped mesoporous carbon nanospheres and graphene

Zhen, Qingfang; Ma, Huiyuan; Jin, Zhongxin; Zhu, Di; Liu, Xiao; Sun, Yu; Zhang, Chunjing

doi:10.1039/d1nj00019e

Cited by 21 publications

(8 citation statements)

References 42 publications

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“…Therefore, PARPi is used to induce cell death in tumors with homologous recombination (HR) deficiency (Murai et al, 2012;Murai et al, 2014). Ginsenoside Rg1 was reported to inhibit the expression of a key DNA double-strand break repair factor and CtBP interacting protein, thereby impairing HR (Zhen et al, 2018). Chemical sensitivity analysis showed that the combination of Rg1 and olaparib, a first-line PARPi, improves the therapeutic effect of hepatoblastoma treatment.…”

Section: Research Progress In the Use Of Ginsenosides In Immunotherap...mentioning

confidence: 99%

Ginsenosides: Allies of gastrointestinal tumor immunotherapy

Feng

et al. 2022

Front. Pharmacol.

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In the past decade, immunotherapy has been the most promising treatment for gastrointestinal tumors. But the low response rate and drug resistance remain major concerns. It is therefore imperative to develop adjuvant therapies to increase the effectiveness of immunotherapy and prevent drug resistance. Ginseng has been used in Traditional Chinese medicine as a natural immune booster for thousands of years. The active components of ginseng, ginsenosides, have played an essential role in tumor treatment for decades and are candidates for anti-tumor adjuvant therapy. They are hypothesized to cooperate with immunotherapy drugs to improve the curative effect and reduce tumor resistance and adverse reactions. This review summarizes the research into the use of ginsenosides in immunotherapy of gastrointestinal tumors and discusses potential future applications.

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Section: Research Progress In the Use Of Ginsenosides In Immunotherap...mentioning

confidence: 99%

Ginsenosides: Allies of gastrointestinal tumor immunotherapy

Feng

et al. 2022

Front. Pharmacol.

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“…Therefore, simple and sensitive detection of rutin in pharmaceuticals is of crucial significance. Currently, several analysis methods including high-performance liquid chromatography, electrochemical analysis method, − chemiluminescence method, and UV–Vis spectrophotometry have been reported for rutin detection. Most of these methods need complex operation, expensive instruments, and time-consuming operation.…”

Section: Introductionmentioning

confidence: 99%

Water Soluble Silicon Nanoparticles as a Fluorescent Probe for Highly Sensitive Detection of Rutin

Pan

Qin

et al. 2022

ACS Omega

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In this work, water-soluble fluorescent silicon nanoparticles (SiNPs) were prepared by one-pot hydrothermal method using 3-(2-aminoethylamino)propyldimethoxymethylsilane (AEAPDMMS) as a silicon source and amidol as a reducing agent. The prepared SiNPs showed bright green fluorescence, excellent stability against photobleaching, salt tolerance, temperature stability, and good water solubility. Due to the internal filtration effect (IFE), rutin could selectively quench the fluorescence of the SiNPs. Based on such phenomena, a highly sensitive fluorescence method was established for rutin detection. The linear range and limit of detection (LOD) were 0.05–400 μM and 15.2 nM, respectively. This method was successfully applied to detect rutin in the samples of rutin tablets, Sophora japonica , fry Sophora japonica , and S. japonica carbon with satisfactory recovery.

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“…Graphene (GRA) is constituted by a single layer of sp 2 -hybridized carbon with different electrical and structural properties that are vital for the development of sensors [24][25]; this material is currently being explored in various industrial applications and for the development of new sensors [25,[30][31] and biosensors [25,[32][33] targeted at enhancing the catalytic activity of these devices. GRA is an interesting material which is characterized by high surface area, great electronic transfer, excellent conductivity, low cost, and ease of preparation [25,34].…”

Section: Introductionmentioning

confidence: 99%

Using Carbon Paste Electrode Modified with Graphene and Nanodiamond for the Determination of Nimesulide in Biologic and Environmental Samples

et al. 2022

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The present work reports the development and application of a new carbon paste electrode modified with graphene and nanodiamond for the determination of nimesulide in biological and environmental samples. The morphology and electrochemical properties of the carbon nanostructures were characterized by scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy. The application of the proposed electrochemical sensor led to a significant improvement in the analytical signal and nimesulide oxidation was found to occur at a potential of +0.97 V (vs. Ag/AgCl (3.0 mol L−1 KCl)). The determination of nimesulide was performed based on the application of differential pulse voltammetry, and the results obtained showed a linear concentration range of 0.50–9.0 μmol L−1 (r=0.999) with limit of detection of 15 nmol L−1. The proposed analytical method was successfully applied for the determination of nimesulide in spiked river water, serum and synthetic urine samples, where recoveries close to 100 % were obtained.

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Electrochemical sensor for rutin detection based on N-doped mesoporous carbon nanospheres and graphene

Abstract: In this work, a novel composite based on N-doped mesoporous carbon nanospheres and graphene (N-MCS@graphene) is successfully designed and constructed for the rutin (RT) detection. The ordered mesoporous architecture offers...

Cited by 21 publications

References 42 publications

Ginsenosides: Allies of gastrointestinal tumor immunotherapy

Ginsenosides: Allies of gastrointestinal tumor immunotherapy

Water Soluble Silicon Nanoparticles as a Fluorescent Probe for Highly Sensitive Detection of Rutin

Using Carbon Paste Electrode Modified with Graphene and Nanodiamond for the Determination of Nimesulide in Biologic and Environmental Samples

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