Electrochemical Sensor for Dapsone Using Molecularly Imprinted Polypyrrole Membrane as a Recognition Element

Abstract

An electrochemical sensor based on molecularly imprinted polypyrrole membrane is reported for the determination of dapsone (DDS). The sensor was prepared by electropolymerization of pyrrole at a glassy carbon electrode in the presence of DDS as a template. The electropolymerization was performed in the presence of an aqueous solution of 0.1 M HCl, and 0.2 M pyrrole, with and without a template molecule (DDS) at a glassy carbon electrode using cyclic voltammetry. Some of the parameters, important to controlling the performance of the polypyrrole, were investigated and optimized, including the effects of pH, monomer and template concentrations, electropolymerization cycles. The molecularly imprinted film exhibited a high selectivity and sensitivity toward dapsone. The differential pulse voltammetry (DPV) peak current showed a linear dependence on the DDS concentration and a linear calibration curve was obtained in the range 1.0 μM to 110 μM of DDS with a correlation coefficient of 0.998 with a detection limit of 3.0 × 10 −7 M (S/N = 3). The electrode was successfully applied to the determine Dapsone in spiked human serum and urine.

Electrochemical Determination of Naloxone Using Molecularly Imprinted Poly(para-phenylenediamine) Sensor

“…22 In addition, MIPs of PDAs can be made thin and continuous, a feature required to afford a short response time of chemical sensors. 22 In the last five years, chemically and mechanically stable ultrathin electrosynthesized MIP films of PDA have been prepared on various substrates and applied for sensitive detection of a number of small molecules including drugs, 12,[25][26][27][28][29][30] herbicides, [31][32][33] hormone 34,35 and animal feed additive. 36 In this work, we analyzed the function of a p-PDA MIP electrochemical sensor in the rapid and sensitive measurement of NLX.…”

An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite

“…PPy can be overoxidized in a sodium hydroxide (NaOH) solution during several scans of cyclic voltammetry. This process plays a positive role during the formation of MIP since it introduces oxygen groups (carboxyl, carbonyl, and hydroxyl) into the OPPy backbone [ 29 , 30 ], which could be suitable for the recognition of sulfadiazine positive groups. However, this process makes the polymer film less conductive.…”

Spectrophotometric Determination of Dapsone Using Charge Transfer Complex Formation Reaction

“…Various analytical techniques have been reported for the determination of Dapsone drug such as chromatography [5,6,7,8], voltammetry [9], and chemiluminescence [10].…”