Electrochemical Sensor Based on Ni-Co Layered Double Hydroxide Hollow Nanostructures for Ultrasensitive Detection of Sumatriptan and Naproxen

Abstract

In this work, Ni–Co layered double hydroxide (Ni–Co LDH) hollow nanostructures were synthesized and characterized by X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), and Fourier-transform infrared spectroscopy (FT-IR) techniques. A screen-printed electrode (SPE) surface was modified with as-fabricated Ni–Co LDHs to achieve a new sensing platform for determination of sumatriptan. The electrochemical behavior of the Ni–Co LDH-modified SPE (Ni–CO LDH/SPE) for sumatriptan determination was investigated using voltammetric methods. Compared with bare SPE, the presence of Ni–Co LDH was effective in the enhancement of electron transport rate between the electrode and analyte, as well as in the significant reduction of the overpotential of sumatriptan oxidation. Differential pulse voltammetry (DPV) was applied to perform a quantitative analysis of sumatriptan. The linearity range was found to be between 0.01 and 435.0 µM. The limits of detection (LOD) and sensitivity were 0.002 ± 0.0001 μM and 0.1017 ± 0.0001 μA/μM, respectively. In addition, the performance of the Ni–CO LDH/SPE for the determination of sumatriptan in the presence of naproxen was studied. Simultaneous analysis of sumatriptan with naproxen showed well-separated peaks leading to a quick and selective analysis of sumatriptan. Furthermore, the practical applicability of the prepared Ni–CO LDH/SPE sensor was examined in pharmaceutical and biological samples with satisfactory recovery results.

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

“…Compared to traditional biosensors, LDHs biosensors have good selectivity, high sensitivity, good repeatability, and low production costs, and are expected to become a promising type of biosensor. [ 35 ] In recent years, LDHs biosensors have been primarily studied for the detection of lactate, [ 289 , 290 ] DNA, [ 159 ] H 2 O 2 , [ 292 , 293 ] amino acids, [ 294 , 295 ] dopamine, [ 294 , 296 ] and other biologically active molecules [ 37 , 297 ] and drug molecules [ 298 , 299 ] in biological samples or living cells. The common strategy for using LDHs in biosensors is to modify the electrode with LDHs‐based materials according to the detection requirements.…”

“…The common strategy for using LDHs in biosensors is to modify the electrode with LDHs‐based materials according to the detection requirements. The commonly used electrode substrates include glassy carbon electrode (GCE), [ 37 , 291 , 292 , 293 , 294 , 295 , 296 ] screen‐printed electrode (SPE), [ 289 , 290 , 298 ] fluorine‐doped tin oxide (FTO) electrode, [ 299 ] and modified indium tin oxide (ITO) electrode. [ 297 ] In recent years, LDHs based on transition metals such as Fe, Mn, Ni, and Co have received great attention because they have outstanding advantages over previous metal catalysts, including high electrocatalytic activity, tunable morphology, increased active surface area, excellent durability, fast electron transfer ability, and high natural abundance.…”

“…[ 52 ] Therefore, in recent research related to LDHs biosensors, transition metal‐based LDHs have been widely studied. [ 37 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 298 ] Here, we have an overview of LDH biosensors and organized the relevant parameters of the LDHs biosensors prepared in these studies in Table 3 .…”

“…Recently, an SPE electrode was modified with hollow NiCo LDHs for the determination of sumatriptan in the presence of naproxen. [ 298 ] Another interesting study prepared hollow MnNi LDHs (h‐MnNi LDHs) for the detection of uracil‐DNA glycosylase (UDG). [ 37 ] However, the h‐MnNi LDHs prepared in this study were not directly used to modify the electrode, but were used in a cascade reaction to amplify the low concentration of UDG signal.…”

Glassy Carbon Electrode Modified with CB/TiO2 Layer for Sensitive Determination of Sumatriptan by Means of Voltammetry and Flow Injection Analysis

“…Different methods of sumatriptan determination have been reported in the literature, including spectrophotometry [ 20 ], spectrofluorimetry [ 21 , 22 ], or liquid chromatography coupled with various detectors [ 19 , 23 , 24 ]. Additionally, electrochemical methods, including voltammetry, are widely used for this purpose due to low detection limits, easiness of use, and low costs of analysis [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. However, the electrochemical methods also have their limitations, such as higher sensitivity to the complex matrices or higher detection limits in comparison with, e.g., chromatographic methods.…”