Electrochemical Sensing of Dopamine Using Polypyrrole/Molybdenum Oxide Bilayer-Modified ITO Electrode

Alahmadi, Nadiyah; El‐Said, Waleed A.

doi:10.3390/bios13060578

Cited by 4 publications

(4 citation statements)

References 83 publications

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“…Moreover, the sensor showcased excellent selectivity for DA detection, even in the presence of common interferents such as glucose, AA, and UA, effectively distinguishing dopamine and highlighting the designed electrode ability to function in complex biological environments. Table 5 summarizes various electrocatalysts reported towards sensing of DA [ 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 ].…”

Section: Electrochemical Sensing Of Biomoleculesmentioning

confidence: 99%

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Kuntoji,

Kousar,

Gaddimath

et al. 2024

Biosensors

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Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors to biomolecules, requiring adept conversion and amplification of interactions into various signal modalities like electrical, optical, gravimetric, and electrochemical outputs. Overcoming challenges associated with sensitivity, detection limits, response time, reproducibility, and stability is essential for efficient biosensor creation. The central aspect of the fabrication of any biosensor is focused towards forming an effective interface between the analyte electrode which significantly influences the overall biosensor quality. Polymers and macromolecular systems are favored for their distinct properties and versatile applications. Enhancing the properties and conductivity of these systems can be achieved through incorporating nanoparticles or carbonaceous moieties. Hybrid composite materials, possessing a unique combination of attributes like advanced sensitivity, selectivity, thermal stability, mechanical flexibility, biocompatibility, and tunable electrical properties, emerge as promising candidates for biosensor applications. In addition, this approach enhances the electrochemical response, signal amplification, and stability of fabricated biosensors, contributing to their effectiveness. This review predominantly explores recent advancements in utilizing macrocyclic and macromolecular conjugated systems, such as phthalocyanines, porphyrins, polymers, etc. and their hybrids, with a specific focus on signal amplification in biosensors. It comprehensively covers synthetic strategies, properties, working mechanisms, and the potential of these systems for detecting biomolecules like glucose, hydrogen peroxide, uric acid, ascorbic acid, dopamine, cholesterol, amino acids, and cancer cells. Furthermore, this review delves into the progress made, elucidating the mechanisms responsible for signal amplification. The Conclusion addresses the challenges and future directions of macromolecule-based hybrids in biosensor applications, providing a concise overview of this evolving field. The narrative emphasizes the importance of biosensor technology advancement, illustrating the role of smart design and material enhancement in improving performance across various domains.

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Section: Electrochemical Sensing Of Biomoleculesmentioning

confidence: 99%

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Kuntoji,

Kousar,

Gaddimath

et al. 2024

Biosensors

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“…Table 2 summarizes the LOD and linear range in chronological order for DA detection with antibodies, aptamers, and nano-particles [ 63 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ].…”

Section: Evolution Of the Dopamine Biosensors After Receptor Elementmentioning

confidence: 99%

“…Table 2 summarizes the LOD and linear range in chronological order for DA detection with antibodies, aptamers, and nano-particles [63,[76][77][78][79][80][81][82][83]. More examples of DA biosensors containing classifications of nanomaterials are collected in another review article from 2021 [32].…”

Section: Nano-particles Nanomaterials Enhanced Electrodesmentioning

confidence: 99%

From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine

Ravariu

2023

Biosensors

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Neurotransmitters are an important category of substances used inside the nervous system, whose detection with biosensors has been seriously addressed in the last decades. Dopamine, a neurotransmitter from the catecholamine family, was recently discovered to have implications for cardiac arrest or muscle contractions. In addition to having many other neuro-psychiatric implications, dopamine can be detected in blood, urine, and sweat. This review highlights the importance of biosensors as influential tools for dopamine recognition. The first part of this article is related to an introduction to biosensors for neurotransmitters, with a focus on dopamine. The regular methods in their detection are expensive and require high expertise personnel. A major direction of evolution of these biosensors has expanded with the integration of active biological materials suitable for molecular recognition near electronic devices. Secondly, for dopamine in particular, the miniaturized biosensors offer excellent sensitivity and specificity and offer cheaper detection than conventional spectrometry, while their linear detection ranges from the last years fall exactly on the clinical intervals. Thirdly, the applications of novel nanomaterials and biomaterials to these biosensors are discussed. Older generations, metabolism-based or enzymatic biosensors, could not detect concentrations below the micro-molar range. But new generations of biosensors combine aptamer receptors and organic electrochemical transistors, OECTs, as transducers. They have pushed the detection limit to the pico-molar and even femto-molar ranges, which fully correspond to the usual ranges of clinical detection of human dopamine in body humors that cover 0.1 ÷ 10 nM. In addition, if ten years ago the use of natural dopamine receptors on cell membranes seemed impossible for biosensors, the actual technology allows co-integrate transistors and vesicles with natural receptors of dopamine, like G protein-coupled receptors. The technology is still complicated, but the uni-molecular detection selectivity is promising.

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“…With technological advancements, electrochemical biosensing technology is gradually replacing traditional biological sensing techniques for various applications like dopamine and glucose detection. Currently, the limit of detection (LOD) achieved through electrochemical techniques is approximately 1-25 nM [20][21][22][23][24] and 0.1-0.3 µM [25][26][27] for dopamine and glucose, respectively. Notably, fruitful results have also been obtained in utilizing electrochemical detection for UA research [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Polypyrrole/α-Fe2O3 Hybrids for Enhanced Electrochemical Sensing Performance towards Uric Acid

Wang,

Liu,

Song

et al. 2024

Coatings

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Uric acid, a metabolite formed by the oxidation of purines in the human body, plays a crucial role in disease development when its metabolism is altered. Various techniques have been employed for uric acid analysis, with electrochemical sensing emerging as a sensitive, selective, affordable, rapid, and simple approach. In this study, we developed a polymer-based sensor (PPy/α-Fe2O3) for the accurate determination of uric acid levels. The PPy/α-Fe2O3 hybrids were synthesized using an uncomplicated in situ growth technique. Characterization of the samples was performed using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The electrochemical sensing performance towards uric acid was evaluated through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The obtained results demonstrated that the sensor exhibited excellent sensitivity towards uric acid detection within a wide range of 5–200 μM with a limit of detection (LOD) as low as 1.349 μM. Furthermore, this work elucidated the underlying sensing mechanism and highlighted the pivotal role played by PPy/α-Fe2O3 hybrids in enabling efficient uric acid sensing applications using electrochemical sensors.

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Electrochemical Sensing of Dopamine Using Polypyrrole/Molybdenum Oxide Bilayer-Modified ITO Electrode

Cited by 4 publications

References 83 publications

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine

Polypyrrole/α-Fe2O3 Hybrids for Enhanced Electrochemical Sensing Performance towards Uric Acid

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