Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

Pankratova, N. A.; Jović, Milica; Pfeifer, M.

doi:10.1039/d1ra00589h

Cited by 13 publications

(6 citation statements)

References 199 publications

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“…A point-of-care (POC) platform would enable rapid triage directly at the site of injury without requiring processing in a laboratory, thanks to its small and portable nature, the reduced requirement of sample volume, and fast turnaround time. It could also be used for monitoring and assessment in the ambulance and for monitoring the patient’s response at the hospital, with repeated measurements [ 32 , 36 , 38 ]. Many POC designs are available, but a critical difference that can enhance their quality is the presence of a built-in control that can indicate the correct execution of the assay.…”

Section: Resultsmentioning

confidence: 99%

Challenges of the Effectiveness of Traumatic Brain Injuries Biomarkers in the Sports-Related Context

Tomaiuolo

Zibetti

Resta

et al. 2023

JCM

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Traumatic brain injury affects 69 million people every year. One of the main limitations in managing TBI patients is the lack of univocal diagnostic criteria, including the absence of standardized assessment methods and guidelines. Computerized axial tomography is the first-choice examination, despite the limited prevalence of positivity; moreover, its performance is undesirable due to the risk of radiological exposure, prolonged stay in emergency departments, inefficient use of resources, high cost, and complexity. Furthermore, immediacy and accuracy in diagnosis and management of TBIs are critically unmet medical needs. Especially in the context of sports-associated TBI, there is a strong need for prognostic indicators to help diagnose and identify at-risk subjects to avoid their returning to play while the brain is still highly vulnerable. Fluid biomarkers may emerge as new prognostic indicators to develop more accurate prediction models, improving risk stratification and clinical decision making. This review describes the current understanding of the cellular sources, temporal profile, and potential utility of leading and emerging blood-based protein biomarkers of TBI; its focus is on biomarkers that could improve the management of mild TBI cases and can be measured readily and directly in the field, as in the case of sports-related contexts.

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Section: Resultsmentioning

confidence: 99%

Challenges of the Effectiveness of Traumatic Brain Injuries Biomarkers in the Sports-Related Context

Tomaiuolo

Zibetti

Resta

et al. 2023

JCM

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“…For a discussion of electrochemical sensing of TBI biomarkers beyond that presented here, the authors refer the reader to the recent review by Pankratova et al [87].…”

Section: Electrochemical Detectionmentioning

confidence: 99%

The Current State of Traumatic Brain Injury Biomarker Measurement Methods

2021

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Traumatic brain injury (TBI) is associated with high rates of morbidity and mortality partially due to the limited tools available for diagnosis and classification. Measuring panels of protein biomarkers released into the bloodstream after injury has been proposed to diagnose TBI, inform treatment decisions, and monitor the progression of the injury. Being able to measure these protein biomarkers at the point-of-care would enable assessment of TBIs from the point-of-injury to the patient’s hospital bedside. In this review, we provide a detailed discussion of devices reported in the academic literature and available on the market that have been designed to measure TBI protein biomarkers in various biofluids and contexts. We also assess the challenges associated with TBI biomarker measurement devices and suggest future research directions to encourage translation of these devices to clinical use.

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“…43,44 Owing to the nature of central nervous system (CNS) injuries, the need for rapid and on-site diagnosis of these diseases in emergency rooms, concussion clinics, hospitals, surgery rooms, or other walk-in clinical settings has been emphasized by clinicians to provide appropriate treatments in an expedited manner. 45…”

Section: Introductionmentioning

confidence: 99%

Autonomous electrochemical biosensing of glial fibrillary acidic protein for point-of-care detection of central nervous system injuries

et al. 2022

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Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

Abstract: Critical review on the electrochemical (EC) protocols suggested in the literature for the quantification of protein biomarkers relevant to mild traumatic brain injury (mTBI).

Cited by 13 publications

References 199 publications

Challenges of the Effectiveness of Traumatic Brain Injuries Biomarkers in the Sports-Related Context

Challenges of the Effectiveness of Traumatic Brain Injuries Biomarkers in the Sports-Related Context

The Current State of Traumatic Brain Injury Biomarker Measurement Methods

Autonomous electrochemical biosensing of glial fibrillary acidic protein for point-of-care detection of central nervous system injuries

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