Electrochemical sensing based on graphene oxide/Prussian blue hybrid film modified electrode

Functionalized graphene oxide for clinical glucose biosensing in urine and serum samples

“…Moreover, the sensitivity obtained for this biosensor was much better than that for other reported glucose biosensors, such as poly (3,4- ). 43 In addition, the linear range (up to 20 mM) is much wider than for similar biosensors, such as glucose oxidase immobilized onto a nanocomposite graphene-gold nanoparticle-chitosan film (10 mM), 19 graphene (10 mM), 20 graphene oxide-Prussian blue hybrid film (1.2 mM), 21 silver-DNA hybrid nanoparticles (1.2 mM), 44 a copper self-assembled monolayer nanocomposite on a gold substrate (0.0018 mM), 45 poly(3,4-etheylenedioxythiophene)-Prussian blue multiwalled carbon nanotubes (10.0 mM), 42 highly ordered polyaniline nanotubes (5.5 mM), 46 a chitosangold nanoparticle hybrid film on a Prussian blue-modified electrode (1.6 mM), 47 a highly ordered porous anodic alumina membrane-Prussian blue nanoarray (8.0 mM), 48 and a Prussian blue-modified screen-printed electrode (3.0 mM). The diagnosis of diabetes is made on identification of fasting plasma glucose concentrations $ 126 mg/dL (7.0 mM) on at least two occasions.…”

“…19 Several reports of carbon composite materials, such as graphene-gold nanoparticles-chitosan hybrid film and glucose oxidase-assembled graphene and graphene oxidePrussian blue hybrid film for glucose biosensing have been published. [19][20][21] Although graphene-based electrodes and other electrodes modified by composite materials have demonstrated their utility as electrochemical glucose biosensors in phosphate-buffered saline, and serum and urine samples, 3,[19][20][21][22] to the best of our knowledge, their use for detection of glucose in urine and serum samples from diabetic patients using a functionalized electrode has not yet been studied. Furthermore, the graphene-based composites utilized so far for electrochemical studies have been fabricated by physical modification 19 and are not chemically bonded or functionalized, suggesting lack of long-term binding affinity and stability problems between nanoparticles and graphene oxide during electrochemical analysis.…”

Spontaneous Deposition of Prussian Blue on Reduced Graphene Oxide – Gold Nanoparticles Composites for the Fabrication of Electrochemical Biosensors

“…Both the redox peak currents and peak-to-peak separation increased with increasing scan rate. The linear relationship between peak current and scan rate (from 20 to 200 mV/s) indicated a reversible and surface-confined redox process of PB in the composite film [38].…”

“…Accordingly, the electrochemical reaction occurred at the GC/ RGO-AuNPs-PB/GOD-CHIT electrode in the presence of glucose can be expressed as follows [38,43]:…”

Electrochemical nanosensors: advances and applications

“…An LOD of 31 nM was achieved which showed significant improvement over other graphene based electrodes for peroxide detection. [133][134][135][136][137] The incorporation of PB is common in many peroxide sensors as it has well known electrocatalytic properties for peroxide redox reactions. This is attributed to the unique zeolite structure of PB which allows molecules with low molecular weight and scale to penetrate into the crystal resulting in improved electrocatalysis.…”