Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

“…Different electrodes such as activated GCE [31], MWCNTs/GCE [32], DNA-modified GCE [33,34], hanging mercury drop electrode (HDME) [35] and molecularly imprinted polymer-carbon paste electrode have been used inMTZ electrochemical assays [36,37]. In the present study, the electrochemical behaviour of MTZ and the effects of some experimental variables on the electro reduction of this drug have been investigated on a GR-TiO2 modified GCE by cyclic voltammetry and differential pulse voltammetry techniques.…”

Experimental sensing and density functional theory study of an ionic liquid mediated carbon nanotube modified carbon-paste electrode for electrochemical detection of metronidazole

“…2 Several methods have been reported for determining metronidazole, including various instrumental techniques such as chromatography, [3][4][5][6] spectrophotometry, 7-9 fluorescence 10 in addition to different electrochemical methods. [11][12][13][14][15][16][17][18] Electrochemical methods are widely employed in analytical chemistry to determine pharmaceuticals [19][20][21] due to the fast and easy preparation process, low cost, quick and reliable response. On the other hand, the feasibility of miniaturization and high sensitivity toward trace amount of analytes are other advantages of electrochemical methods.…”

Rapid, sensitive, and validated HPLC method for analysis of metronidazole and tinidazole under identical chromatographic conditions with UV detection and liquid-liquid extraction: application in bioequivalence studies

“…The plasma half-life of metronidazole is 8 h but tinidazole has significantly longer elimination half-life of around 14 h [5]. Several analytical methods have been described for determination of metronidazole either alone or in combination with various drugs in dosage forms or in biological fluids including spectrophotometry [6,7], non-aqueous titration [8], voltammetry [9], electrophoresis [10], and high performance liquid chromatographic (HPLC) methods [11][12][13][14][15][16][17][18][19]. Measurement of tinidazole using HPLC has also been reported [20][21][22][23].…”