Electrochemical Properties of Platelets: Clinical and Pharmacological Applications

Boron Containing Compounds as Protease Inhibitors

“…Thrombin (human and mammalian) is a trypsin-like serine protease that plays a central role in hemostasis and induces platelet aggregation and secretion. , It is the final enzyme in the blood coagulation cascade that hydrolyses factors V, VIII, and XIII and fibrinogen, releasing fibrinopeptides A and B, which generate fibrin. The polymerization of fibrin produces the core of a blood clot.…”