Electrochemical Properties of Nucleic Acid Components

Vetterl, Vladimír; Hasoň, Stanislav

doi:10.1016/s1871-0069(05)01002-5

Cited by 12 publications

(11 citation statements)

References 255 publications

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“…The spikes were only observed with the alkylsulfanylphenyl‐modified nucleosides; neither of the building blocks (unmodified nucleosides, PBA RS ) nor the dN RS MP (N=A or C) compounds produced such effects, which suggests the involvement of both the nucleobase and the RS moiety. Occurrence of sharp spikes in voltammograms has been shown to be connected with phase transitions in compact, two‐dimensionally condensed layers of various surface‐active substances (including nucleic acid components) at electrically charged surfaces 24. The 2D condensation processes are usually connected with a strong decrease of differential capacity of the electrode bilayer in AC voltammetric modes, reflected in the decrease of capacitive currents well below values that correspond to a clean electrode surface in the background electrolyte.…”

Section: Resultsmentioning

confidence: 99%

Enucleation of pancreatic neoplasms

Crippa

Bassi

Salvia

et al. 2007

British Journal of Surgery

160

115

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Section: Resultsmentioning

confidence: 99%

Enucleation of pancreatic neoplasms

Crippa

Bassi

Salvia

et al. 2007

British Journal of Surgery

160

115

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“…Association of unmodified bases, nucleosides and nucleotides at the mercury surface at higher bulk concentrations was earlier described [34,35]. High electron yield catalytic peak of DNA-Os(VIII)bipy adducts was earlier shown to be of great analytical value, including its use in DNA sensors [6,25,36,37].…”

Section: Cyclic Voltammetry Of Os Bipy-modified Thymine Nucleosidesmentioning

confidence: 91%

Covalent Labeling of Nucleosides with VIII‐ and VI‐Valent Osmium Complexes

et al. 2007

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Osmium tetroxide complexes with nitrogen ligands [Os(VIII)L] have been widely applied as probes of the DNA structure and as electroactive labels of DNA. Here we describe the electrochemical behavior of Os(VIII)2,2-bipyridine (Os, bipy)-base-labeled nucleosides. We show that electroactive label can be introduced also in the nucleoside ribose residues using six-valent osmium complex. Cyclic voltammograms of sugar-Os(VI)-modified ribosides are similar but not identical to those of the base-modified ribosides. Our results showing the electroactivity of sugar modified ribosides pave the way to facile end-labeling of RNA.

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“…Occurrence of sharp spikes in voltammograms has been shown to be connected with phase transitions in compact, two-dimensionally condensed layers of various surface-active substances (including nucleic acid components) at electrically charged surfaces. [24] The 2D condensation processes are usually connected with a strong decrease of differential capacity of the electrode bilayer in AC voltammetric modes, reflected in the decrease of capacitive currents well below values that correspond to a clean electrode surface in the background electrolyte. Formation of capacitance pits with flat bottoms and distinct edges that correspond to the above mentioned spikes are also observed, at potentials where the phase transitions (condensation/reorientation/disruption of the compact layers) occur.…”

Section: Rsmentioning

confidence: 99%

Alkylsulfanylphenyl Derivatives of Cytosine and 7‐Deazaadenine Nucleosides, Nucleotides and Nucleoside Triphosphates: Synthesis, Polymerase Incorporation to DNA and Electrochemical Study

Macíčková-Cahová

Pohl

Horáková

et al. 2011

Chemistry A European J

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Aqueous Suzuki-Miyaura cross-coupling reactions of halogenated nucleosides, nucleotides and nucleoside triphosphates derived from 5-iodocytosine and 7-iodo-7-deazaadenine with methyl-, benzyl- and tritylsufanylphenylboronic acids gave the corresponding alkylsulfanylphenyl derivatives of nucleosides and nucleotides. The modified nucleoside triphosphates were incorporated into DNA by primer extension by using Vent(exo-) polymerase. The electrochemical behaviour of the alkylsulfanylphenyl nucleosides indicated formation of compact layers on the electrode. Modified nucleotides and DNA with incorporated benzyl- or tritylsulfanylphenyl moieties produced signals in [Co(NH(3))(6)](3+) ammonium buffer, attributed to the Brdička catalytic response, depending on the negative potential applied. Repeated constant current chronopotentiometric scans in this medium showed increased Brdička catalytic response, which suggests the deprotection of the alkylsulfanyl derivatives to free thiols under the conditions.

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Electrochemical Properties of Nucleic Acid Components

Cited by 12 publications

References 255 publications

Enucleation of pancreatic neoplasms

Enucleation of pancreatic neoplasms

Covalent Labeling of Nucleosides with VIII‐ and VI‐Valent Osmium Complexes

Alkylsulfanylphenyl Derivatives of Cytosine and 7‐Deazaadenine Nucleosides, Nucleotides and Nucleoside Triphosphates: Synthesis, Polymerase Incorporation to DNA and Electrochemical Study

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