Electrochemical Preparation of Gold Nanoparticles-Polypyrrole Co-Decorated 2D MoS₂ Nanocomposite Sensor for Sensitive Detection of Glucose

Abstract

A sensitive electrochemical sensor was fabricated based on two dimensional (2D) MoS 2 nanosheets (MoS 2 ), gold nanoparticles (AuNPs) and polypyrrole (PPY) nanocomposite modified glass carbon electrode (GCE) for glucose detection. Liquid phase exfoliation (LPE) method was applied for the synthesis of 2D MoS 2 nanosheets using N, N-dimethylformamide (DMF). The fabrication of sensor involved the electrochemical deposition of AuNPs on GCE using cyclic voltammetry (CV) followed by drop-casting of 2D MoS 2 nanosheets to prepare MoS 2 -AuNPs/GCE electrode. Pyrrole was then electropolymerized on MoS 2 -AuNPs/GCE surface using amperometry. The structural properties of prepared nancomposites were characterized by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) and fourier transform infra red (FTIR) spectroscopic techniques. The prepared MoS 2 -PPY-AuNPs/GCE electrode was applied for electrochemical sensing of glucose by differential pulse voltammetry (DPV) in NaOH solution. Cu(II)/Cu(III) redox couple was utilized as catalytic center which converted glucose into gluconolactone at an oxidation potential of +0.45 V. The fabricated electrode showed a detection limit (LOD) of 0.08 nM and a quantification limit (LOQ) of 0.26 nM. Furthermore, it exhibited high reproducibility (2.48%), long term stability and high selectivity toward glucose detection. The electrode was found suitable for glucose detection in human serum samples with recoveries ranging from 97%-102.1%.

Functionalization of 2D MoS2 Nanosheets with Various Metal and Metal Oxide Nanostructures: Their Properties and Application in Electrochemical Sensors

“…Controlling the interactions of enzymes with the substrate to improve electron transfer processes remains a challenge that causes a substantial loss of GOx activity, leading to poor overall performance of the sensor. Therefore, other researchers saw an opportunity to explore various 2D MoS 2 /metal-NS composites (Ni-MoS 2 [ 35 ], CuO-MoS 2 [ 82 ], Cu-MoS 2 [ 85 ], Au-Pd/MoS 2 [ 89 ], Cu 2 O-MoS 2 [ 93 ], NiO-MoS 2 [ 103 ], NiCo 2 O 4 -MoS 2 [ 108 ], and MoS 2 -PPY-Au [ 206 ]) as electrode materials to construct non-enzymatic sensors due to their extraordinary electrocatalytic activities, excellent conductivity, and large surface areas. The experimental results revealed that the performances of all these 2D MoS 2 /metal-NS composites were remarkable, as shown in Table 2 .…”

Enzyme-Free Glucose Biosensors Based on MoS2 Nanocomposites

“…3c). Instead of using conventional bimetallic nanoparticles which often made from expensive metals, Ma et al designed a gold nanoparticle-polypyrrole (PPY) co-decorated MoS 2 nanocomposite [38]. The metal/conductive polymer hybrids are also expected to improve the surface area and conductivity of a sensor electrode.…”

Mo-Based Layered Nanostructures for the Electrochemical Sensing of Biomolecules

“…For example, it is well known that the Ni 3+ /Ni 2+ redox couple offers an exceptional catalytic activity in alkaline conditions [ 71 ]. Many studies have therefore been reported on the use of MoS 2 nanosheets as a large area support to immobilize metal nanoparticles [ 69 , 72 , 73 ]. Huang et al tested MoS 2 nanosheets decorated with Cu.…”