Electrochemical Polarization in Isopropyl Ether

Rider, John A.

doi:10.1063/1.1740564

Cited by 3 publications

(1 citation statement)

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“…Various optical methods have been previously employed to identify liquid phase boundaries, including the measurement of differences in refractive index, UV absorbance, and light reflection 30,31 . Given the dramatic differences in electrical conductivities between diisopropyl ether 32 and the strongly acidic solutions required for Bi target dissolution and 211 At solvent extraction 33,34 , we opted to develop a sensor that identifies the phase boundary by monitoring the phases’ ability to carry an electrical current.…”

Section: Introductionmentioning

confidence: 99%

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets

O’Hara

Krzysko

Hamlin

et al. 2019

Sci Rep

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Cyclotron-produced astatine-211 (211At) shows tremendous promise in targeted alpha therapy (TAT) applications due to its attractive half-life and its 100% α-emission from nearly simultaneous branched alpha decay. Astatine-211 is produced by alpha beam bombardment of naturally monoisotopic bismuth metal (209Bi) via the (α, 2n) reaction. In order to isolate the small mass of 211At (specific activity = 76 GBq·µg−1) from several grams of acid-dissolved Bi metal, a manual milliliter-scale solvent extraction process using diisopropyl ether (DIPE) is routinely performed at the University of Washington. As this process is complex and time consuming, we have developed a fluidic workstation that can perform the method autonomously. The workstation employs two pumps to concurrently deliver the aqueous and organic phases to a mixing tee and in-line phase mixer. The mixed phases are routed to a phase settling reservoir, where they gravity settle. Finally, each respective phase is withdrawn into its respective pump. However, development of a phase boundary sensor, placed in tandem with the phase settling reservoir, was necessary to communicate to the system when withdrawal of the denser aqueous phase was complete (i.e., the intersection of the two phases was located). The development and optimization of the autonomous solvent extraction system is described, and the 211At yields from several ~1.1 GBq-level 211At processing runs are reported.

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Section: Introductionmentioning

confidence: 99%