Electrochemical paper-based biosensors for point-of-care diagnostics: Detection methods and applications

Abstract

Personalized health care (PHC) includes personalized, preventive, predictive and participatory approaches that are significant in new diagnostics. This personal health care requires fast, accurate and minimally invasive diagnostic tools that make it possible to evaluate and monitor the process of disease by diagnosing specific disease biomarkers. Point-of-care testing (POCT) involves a wide range of diagnostic tools that meet this purpose. Electrochemical paper-based devices (ePADs) have been introduced as simple, inexpensive, portable and disposable measurement devices to be used in many POCT applications, especially in handling emergencies and outpatient as well as remote usages. Electrochemical detection is a real quantitative detection method with better sensitivity, selectivity and detection limits than indirect measurement methods. In recent years, there has been a revolution in quantitative detections by POCT, thanks to the benefits of electro­chemical sensors and paper substrates. In this paper, recent developments in ePADs, focus­ing on the properties of paper, reasons for its use in the devices, techniques of device and electrode fabrications, and their application particularly in clinical diagnosis, are reviewed.

Flexible electrochemical paper-based device for detection of breast cancer-derived exosome using nickel nanofoam 3D nanocomposite

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Study on Corrosion Monitoring of Reinforced Concrete Based on Longitudinal Guided Ultrasonic Waves

“…Monitoring the corrosion status of reinforcement in concrete has been a topical research in civil engineering. The current detection methods are still based on indirect measurements [4], such as chloride content, concrete resistivity, and half-cell potential, which are used to indirectly determine the corrosion status of the reinforcement by measuring the corrosion environment parameters of the reinforcement inside the concrete [5].…”

Development of conducting paper-based electrochemical biosensor for procalcitonin detection

“…The cellulose fiber paper (CFP) is strong, has a very good bonding ability, and its application has specific demands. Due to its good absorption capacity, particles can be retained on the surface for a longer time, and as a substrate, it exhibits strong antigen-antibody interaction [4,5]. This CFP substrate is used in the development of various sensors and other research applications at the nanoscale, such as membrane affinity, tissue engineering, and assay development, because it has a large surface area, one-dimensional configuration, and good coordination with surface molecules [6][7][8].…”