Electrochemical oxidation of sulfamethazine on a glassy carbon electrode modified with graphene and gold nanoparticles

Cesarino, Ivana; Simões, Rafael Plana; Lavarda, Francisco Carlos; Batagin‐Neto, Augusto

doi:10.1016/j.electacta.2016.01.178

Cited by 44 publications

(25 citation statements)

References 33 publications

(40 reference statements)

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“…GO was prepared by an improved Hummers’ method according to previously described procedures ,,. Typically, 10 g of graphite and 10 g of NaNO 3 was mixed with 450 mL of H 2 SO 4 (98 %) in a 2500 mL flask.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Silver Nanoparticle‐Graphene Composites for Electroanalysis Applications using Chemical and Electrochemical Methods

2016

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An electrochemical device was developed for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP) using differential pulse voltammetry and glassy carbon (GC) electrodes modified with reduced graphene oxide (rGO) and silver nanoparticle (AgNP) composites, synthesised using both chemical and electrochemical methods. The morphology and electrochemical behaviour of the GC electrodes modified with the rGO/AgNP (chemical method) and rGO‐AgNP (electrochemical method) composites were characterised by scanning electron microscopy and cyclic voltammetry. These techniques demonstrated that, in both methods, the graphene oxide was modified by the AgNPs, and the composite synthesised by the electrochemical method showed a better dispersion of the nanoparticles, resulting in an increase in the surface area compared to the rGO/AgNP composite. The GC/rGO‐AgNP electrode was evaluated and optimised for the simultaneous determination of SMX and TMP, achieving detection limits of 0.6 μmol L−1 for the SMX and 0.4 μmol L−1 for the TMP. The proposed GC/rGO‐AgNP electrochemical device was successfully applied to the simultaneous determination of SMX and TMP in wastewaters samples.

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Section: Methodsmentioning

confidence: 99%

Synthesis of Silver Nanoparticle‐Graphene Composites for Electroanalysis Applications using Chemical and Electrochemical Methods

2016

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“…25,26 In recent years, the use of chemically modified electrodes with RGO dramatically increased as a result of the main advantages obtained with this material for sensing, such as gain in sensitivity and detectability compared with bare electrodes and even with other chemical modifiers, due to the electrocatalytic characteristic of graphene-based materials. 20,[26][27][28][29] The aim of this work was to investigate the use of RGO in the development of a sensitive and stable electrochemical sensor for the determination of CIP in pharmaceutical formulations (tablets) and milk samples. Improved characteristics obtained with RGO allowed for the direct determination of CIP in a complex sample such as milk without a laborious sample preparation step, using square-wave voltammetry (SWV).…”

Section: Introductionmentioning

confidence: 99%

Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor

Faria¹,

Pereira²,

Azevedo³

et al. 2019

J. Braz. Chem. Soc.

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In this paper, a simple, sensitive and precise electroanalytical method was developed using a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode and square wave voltammetry (SWV) for determination of ciprofloxacin in pharmaceutical formulations (tablets) and milk samples. Advantages of this sensor include a potential displacement of 100 mV and a 5-fold current increase for the electrochemical oxidation of ciprofloxacin, which resulted in a highly sensitive sensor, when compared to unmodified electrode. The improved properties of the modified electrode are likely due to the formation of a porous surface evidenced by the change in electrode kinetics (thin-layer diffusion process). The proposed sensor is free from interference of sample matrix (pharmaceutical formulations and low/high-fat milk) avoiding cumbersome processes such as previous separations, solvent extraction, or sample filtration (samples were only diluted in Britton-Robinson buffer solution). The results by SWV showed a limit of detection of 0.21 µmol L -1 (correspondent to 0.069 mg L -1 ), which is lower than the ones obtained using other carbon-based electrodes, relative standard deviations lower than 12%, and satisfactory recoveries in the range from 84 to 109%. The results obtained were statistically similar (95% confidence level) with those performed through high-performance liquid chromatography (HPLC).

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“…Becke's LYP (B3LYP) exchange‐correlation functional and 6‐31G (p,d) basis set were employed. The Polarizable Continuum Model (PCM) was employed for simulating the presence of the solvent at this stage .…”

Section: Methodsmentioning

confidence: 99%

“…In these equations,

q_{k} (N + 1)

q_{k} (N)

and

q_{k} (N - 1)

represent, respectively, the electronic population on the k‐th atom of anionic, cationic and neutral species of the studied compound . In the optimization of the molecular structures, the effects of temperature were disregarded because they are not significant for determination of CAFIs.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Reduced Graphene Oxide Modified with Antimony and Copper Nanoparticles for Levofloxacin Oxidation

2018

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This work presents, for the first time, the oxidation mechanism of levofloxacin combining electrochemical experiments and molecular modelling techniques. Levofloxacin is one of the most widely used antibiotics in the world. The detection of this antibiotic is important, because it cannot be fully assimilated by the human organism, therefore levofloxacin is considerate a hazardous pollutant for environment. Sensors based on reduced graphene oxide (rGO) modified with antimony and copper nanoparticles (NPs) were synthesized, characterized and evaluated for the electrochemical detection of the levofloxacin. The morphological and electrochemical characterization of the composites confirmed that the rGO was modified with the metallic nanoparticles. Molecular modelling studies were performed applying Density Functional Theory (DFT) approach, which indicated that the mechanism of levofloxacin oxidation is given by the loss of two electrons: one from N14 atom and other from C13 atom of the levofloxacin molecule. The glassy carbon electrode (GCE) modified with the SbNPs/rGO and CuNPs/rGO composites were evaluated for the determination of levofloxacin using differential pulse voltammetry (DPV) and achieved detection limit of 4.1×10−8 mol L−1 and 1.7×10−8 mol L−1, respectively, presenting as alternative composites to be used in the analysis of antibiotics.

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Electrochemical oxidation of sulfamethazine on a glassy carbon electrode modified with graphene and gold nanoparticles

Cited by 44 publications

References 33 publications

Synthesis of Silver Nanoparticle‐Graphene Composites for Electroanalysis Applications using Chemical and Electrochemical Methods

Synthesis of Silver Nanoparticle‐Graphene Composites for Electroanalysis Applications using Chemical and Electrochemical Methods

Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor

Evaluation of Reduced Graphene Oxide Modified with Antimony and Copper Nanoparticles for Levofloxacin Oxidation

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